Category: Health

Menstrual cycles and ovulation

The duration of the female cycle varies. The most common cycle duration is between 23 and 35 days. The difference in the length of the menstrual cycles, as a rule, concerns the period before ovulation (the so-called follicular or follicular phase). In most women, from ovulation (when the egg comes out of the ovary) to the beginning of menstruation, it takes from 12 to 16 days (the so-called luteal phase).

Phases of the menstrual cycles

Menstruation: The first day of the menstrual cycles is the first day of menstruation (day 1). Menstruation then lasts from 3 to 7 days. Surely, you know that in the presence of menstrual pain, the most severe pain you experience in the first few days of menstruation. This is because your hormones actively promote the rejection of the uterine mucosa that has grown during the previous menstrual cycle.

Preparing for ovulation: At the beginning of your cycle, the pituitary gland, located at the base of the brain, produces follicle-stimulating hormone (FSH). This is the main hormone that stimulates the ovaries to produce eggs. Follicles are fluid-filled vesicles in the ovaries. Each follicle contains an immature egg. FSH promotes the maturation of a certain number of follicles and the production of the hormone estrogen. On the first day of menstruation, the estrogen content is at its lowest level. Then it begins to rise along with the maturation of the follicles.

As the follicles develop, usually one of them becomes “dominant”, and in this large follicle the egg matures. At the same time, the growing level of estrogen in the body is responsible for saturating the lining of the uterine cavity with nutrients and blood. This is so that in the event of pregnancy, the fertilized egg will have all the nutrients and support needed for growth. High levels of estrogen also contribute to the formation of mucus, a “sperm-friendly” environment (or scientifically, cervical (cervical) mucus of the fertile phase). Perhaps you have paid attention to not thick sticky discharge, which may have a cloudy whitish hue. Spermatozoa move more easily through this mucus and survive for several days.

Understanding the ovulation cycle

Ovulation: The level of estrogen in the body is steadily increasing, and at some point it leads to a sharp increase in the level of luteinizing hormone (ovulatory surge of LH). The surge of LH leads to the rupture of the dominant follicle and the release of a mature egg from it, which then enters the fallopian tube. This process is called ovulation.

Menstrual cycles and ovulation

Many women believe that ovulation occurs on day 14, but 14 days is the average, and most women usually ovulate on another day of the menstrual cycle. The day of ovulation differs from cycle to cycle. Some women claim to experience a pain spasm during ovulation, but most women do not feel anything, and ovulation passes without any signs.

After ovulation: After release, the egg moves along the fallopian tube towards the uterus. Its life cycle is up to 24 hours. The life cycle of the sperm is more variable, however, and is usually between 3 and 5 days. Thus, the days immediately preceding ovulation and the day of ovulation itself are the most fertile – it is then that you have the greatest chance of becoming pregnant. Immediately after ovulation, the follicle begins to produce another hormone – progesterone.

Progesterone contributes to the subsequent preparation of the uterine mucosa for the reception of a fertilized egg. Meanwhile, the empty follicle in the ovary begins to shrink, but it continues to produce progesterone and begins to produce estrogen. During this time, you may experience premenstrual tension syndrome (PMS), such as breast soreness, bloating, drowsiness, depression, and irritability.

Antibiotics in the elderly

Antibiotics in the elderly: Age-related changes in the liver and kidneys contribute to changes in biotransformation and the elimination of many drugs. This may be the reason for the development of side effects of drugs that are usually safe and non-toxic. Atrophic processes in the gastrointestinal mucosa lead to changes in the absorption of certain drugs, which explains the low effectiveness of therapy.

With age, as a result of weight loss and muscle atrophy, the water content in the body decreases (by 10-15%) and the relative weight of adipose tissue increases (in men from 18 to 36%, in women from 33 to 48%). Consequently, in the elderly, the volume of distribution of water-soluble drugs changes, which is accompanied by a certain increase in their concentration in the blood. The volume of distribution of fat-soluble drugs in the elderly increases.

Antibiotics in the elderly

A decrease in the penetration of drugs into the tissues as a result of a decrease in the volume of distribution and the level of tissue blood flow may be one of the reasons for the insufficient clinical and bacteriological effectiveness of antibiotics in elderly patients.

The level of drug metabolism in the liver decreases with age as a result of a decrease in liver mass (after 40 years by 1% per year), hepatic blood flow (from 25 to 65 years by 40-45%) and the activity of microsomal enzymes. This leads to a decrease in the level of presystemic metabolism and phase I metabolism of medicinal drugs in the liver. As a result, the clearance decreases and the serum concentration of those antibacterial drugs that are mainly metabolized (more than 50%) in the liver increases: cefoperazone, doxycycline, lincomycin, clindamycin, chloramphenicol, pefloxacin, macrolides, rifamgscin, etc.

The elimination of most antibiotics is carried out by the kidneys. With age, as a result of atrophy of the cortical layer of the kidneys, the level of glomerular filtration decreases (from 20 to 50 years by 0.4 ml/min per year, after 50 years — by 1 ml/min per year) and tubular secretion (on average by 7% every 10 years). This is accompanied by a slowdown in the excretion of many drugs in elderly patients, which leads to an increase in their concentration in the blood.

In this regard, it is desirable to adjust the administered doses of antibacterial drugs that have a predominantly renal elimination pathway, in accordance with the value of glomerular filtration. This is especially important for potentially toxic drugs: aminoglycosides, vancomycin, carbenicillin, ticarcillin, tetracyclines, clomiphene, polymyxins, etc.

When deciding on the choice of an antibiotic, it is necessary to consider the features of drug interaction, since many elderly patients simultaneously take several drugs from different groups (hypotensive, antianginal, nootropic, etc.).

IVF pills (IVF preparations)

When using assisted reproductive technologies (ART), as a rule, hormonal drugs (IVF pills) are used. IVF preparations are chemical compounds obtained synthetically, which have the same effect on the body as their own sex hormones.

The drugs are used at the stage of ovulation stimulation, to prepare the endometrium for embryo transfer, as well as to support the luteal phase in early pregnancy.

Below we will look at these medications, but the information on them is in no way a prescription and can not be used by patients on their own without the appointment of the attending physician. Our article is for informational purposes only.

Preparations for ovulation stimulation

Antiestrogens

Clomid (clomiphene, clomiphene citrate, clostylbegite). It is available in tablets of 50 mg. In small doses, it increases the secretion of gonadotropins (prolactin, FSH and LH), stimulates ovulation; in high doses, it inhibits the secretion of gonadotropins. It is used both to stimulate ovulation under the control of ultrasound, and in IVF protocols.

IVF pills

Human Menopausal Gonadotropins

IVF pills: Menopur containing 75ED FSH and 75ED LH (Ferring, Germany). Currently, there is a Menopur-Multidose containing 1200 units of FSH and 1200 UNITS of LC, with the ability to dose the drug using a convenient handle.

Menogon containing 75ED FSH and 75ED LH (Ferring, Germany).

Alterpur-urofollitropin (FSH) , available in doses of 75 and 150 IU; (Ibsa, Switzerland). e

Merional (Ibsa, Switzerland), The ratio of the biological activity of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) is 1:1. It is available in a dose of 75ME and 150ME (the dose is measured by FSH).

Bravel (Ferring, Germany) – urofollitropin (a highly purified follicle-stimulating hormone), is available in a dose of 75 MG FSH.

Previously existing menotropins-Pergonal, Metropin, Humegon – are not currently produced.

The use of estrogens in ART

Estrogens in transdermal (through the skin) or oral (through the mouth) forms are used:

  • in programs using cryopreserved embryos
  • in protocols of superovulation stimulation
  • in patients with endometrial hyperplasia in surrogacy programs.

IVF pills: Proginova 2 mg (Delfarm, France) – dragee for oral administration.

Estrofem 2 mg (NOVO NORDISK, Denmark) – tablets for oral administration.

Divigel 0.5 and 1.0 (Orion Corporation, Finland) – gel for external use in single-dose packages.

Estrogel 2.5 mg (Besins, Belgium) – gel for external use, contains 1.5 mg of estradiol in tubes of 80 g with a measuring spatula.

The Council of Experts of the RARCH (Russian Association of Human Reproduction) recommends continuing estrogen therapy during the first trimester of pregnancy in the absence of their own yellow body, its functional insufficiency or endometrial hypoplasia.

When making a list of drugs that we use in our work, you can not choose the best one or make a universal scheme of stimulation. Depending on the clinical situation, the doctor individually selects the drug and its required dose.

! Attention ! All information on the drugs presented in this article is not intended as a prescription and cannot be used by patients independently without the appointment of the attending physician. The article is for informational purposes only.

How clomid affects the body?

How clomid affects the body: Clomid is a drug in tablet form, which contains clomiphene citrate. This drug is a selective estrogen receptor modulator. This term means that the antiestrogen, by binding to estrogen receptors in a certain area of the body, blocks the effect of female sex hormones, but in other tissues it can act as a natural estrogen. In the sports field, this drug is especially popular in post-course therapy due to its properties to prevent the negative effects of estrogens on the hypothalamus and activate increased testosterone production.

Clomid directly affects the estrogen receptors in the pituitary gland and sex glands. By binding to these receptors in the pituitary gland, the antiestrogen interferes with the process of negative feedback – as a rule, estrogens during the action on the pituitary gland reduce the production of lutenizing and follicle-stimulating hormones, but when using clomid, this process is not carried out in the body. From this, you can perfectly understand how clomid affects testosterone, since these gonadotropins contribute to an increase in the concentration of the main male sex hormone in the body.

How clomid affects the body

It is also worth noting that clomid does not affect the level of estrogens in the blood, it only blocks the work of receptors, but female sex hormones become simply inactive in the body.

What effect does the antiestrogen have on the athlete’s body?

Clomid does not affect the metabolic processes of estrogens in the body, so in the case of using this drug, estrogen is freely destroyed by liver enzymes, and does not accumulate in the athlete’s body. To fully understand the principle of the effect of clomid in the body, it is necessary to consider in detail how the antiestrogen affects a particular process. Next, let’s look at the most popular questions:

  • How does clomid affect the spermogram? Initially, since the 70s of the last century, clomid was used as a drug for the treatment of infertility – both male and female. For men, this drug allowed them to fight idiopathic oligospermia – the missing number of sperm cells that are necessary for fertilization of the egg. Therefore, after taking antiestrogens, an increase in the number of active spermatozoa may be observed in the spermogram.
  • How does clomid affect potency? Antiestrogen in sports practice contributes to the normalization of the functioning of the hypothalamus-pituitary-testicular arch. As a result, the concentration of natural testosterone in the body of a man increases, which has a positive effect on erectile function. Most athletes after a course of the steroid are in the so-called “hormonal pit”, which can negatively affect the sexual life. As a result, with the use of clomid, the athlete can observe an improvement in the quality of sexual life, it should also be noted that the timely start of post-course therapy with clomid will avoid testicular atrophy.

To suppress aromatization in the body, aromatase inhibitors – anastrozole, letrozole, or in extreme cases, proviron-are best suited. These drugs, especially the first two, perfectly cope with the symptoms of gynecomastia, excessive fluid retention, high blood pressure and other signs of aromatization.

Clomid, in turn, is used during post-course therapy, while aromatase inhibitors are taken mainly on the course of anabolic and androgenic substances. It allows you to normalize the production of natural testosterone in the body in a short time, and it also eliminates the symptoms of gynecomastia that appeared after a course of steroids. The optimal dosage of antiestrogen is calculated based on how heavy the course was – how many steroids were present on the course, how large the dosages were.

What negative reactions should you be prepared for on the clomid course?

It is not enough to find out how clomid affects libido and spermogram. Also, before taking any medication, it is necessary to find out what side effects an antiestrogen can cause. Failure to comply with the recommended dosages, the optimal duration of the course may lead to the following negative reactions:

  • vertigo;
  • feeling sleepy or, conversely, sleep problems in the form of insomnia;
  • disorders of the digestive system in the form of nausea or vomiting;
  • frequent headaches;
  • the drug is also able to have a toxic effect on the liver, but if you compare it with another fairly popular antiestrogen tamoxifen, its toxicity is much less;
  • it is worth noting how clomid affects vision, neglect of the rules of taking the drug can lead to serious violations of visual function.

The above-mentioned undesirable effects occur in quite rare cases, and if they are observed, they quickly pass after stopping the use of antiestrogen. It is also worth adding that the use of clomid increases the risk of blood clots. But to minimize this effect during the post-course therapy with the use of antiestrogen, it is necessary to increase the volume of consumption of purified water – by at least one liter per day.

How long it will take to recover is calculated individually, depending on the severity of the course. As the reviews indicate, clomid is a fairly effective antiestrogen. Representatives of sports disciplines speak about it mostly positively, negative reviews describing the side effects of clomiphene citrate can be found quite rarely. Many athletes note that with its help it is possible to recover perfectly in a short period of time after a course of anabolic and androgenic steroids, and to minimize losses after AAS.

Bodybuilding and childbearing functions

Bodybuilding and childbearing functions: Let’s try to understand this poorly lit topic. First of all, if you are engaged in bodybuilding as an amateur and without the use of hormones, then you can only talk about the positive aspects associated with the conception of children. Because all you can get from training in the gym is only health and sexuality.

A man is “responsible” for the sex of the unborn child. Fertilizes the egg with a sperm cell with chromosome XX, it will be a girl, and if with chromosome XY, it will be a boy. Observations have shown that boys ‘spermatozoa are “faster” than girls’ spermatozoa, but they die faster (XY-spermatozoa live for several hours, and XX-for several days). Therefore, if the sexual act occurred at the moment when the egg is fully mature (alkaline environment), then there is a greater chance that a nimble boy will “run” to it faster. And if sexual intercourse occurred before the egg is fully mature (acidic environment), then it is more likely that it will be fertilized by the XX-sperm-long-lived.

It is statistically known that the frequency of male births is higher at the first birth and decreases at subsequent births. The younger the future parents, the more likely they are to conceive a boy, and vice versa. In the offspring of bald men, there are one and a half times more boys.
In addition, it is known that children of the weather are more often of the same sex, and if the interval between births is about three years, then in most cases children of the opposite sex are born. If pregnancy occurs shortly after an abortion, girls are more likely to be born.

Bodybuilding and childbearing functions: Steroids and Children

It is not entirely clear how clomid will act on a woman in the case of bodybuilding, do Bodybuilding and childbearing functions affect her? There are many opinions on this topic.

In principle, testosterone itself is a very natural thing for the male body. And they are afraid of some pathologies, I would not. I have a lot of friends who conceived children on the course and everything was always good. For example, the risk of getting unhealthy offspring is much greater if you sometimes drink beer or any other alcoholic beverage because it is possible to damage your germ cells. And if a man has a complete replacement of the sex cells every three months, then women do not have this in principle, and drinking wine, champagne, and even more vodka is a game of”Russian roulette”. Any gram can be fatal for the cell that will be used during pregnancy and then a freak will be born.

Bodybuilding and childbearing functions

However, it is important to know that anabolic steroids are inherently male contraceptives. In fact, it is to prevent unwanted pregnancy that they are often prescribed in many European countries. Experiments show that after a couple of months of using artificial sex hormones (AS), sperm activity drops to zero. You can have sex as before without the risk of an unwanted pregnancy of your girlfriend. That’s all good. But there is one caveat. I was asked recently: why do chemical athletes have a problem with conceiving a boy (girls are most often born). The answer is quite obvious – during the course ( in the first few months until complete sterilization has occurred) and for some time after the course (until spermatogenesis has not recovered at the proper level), the athlete has a low level and motility of sperm. You remember that the boy’s sperm are more nimble and live less. And girls, on the contrary, are slower and live longer. In conditions when spermatozoa are sedentary and there are few of them, it is the more tenacious and slower female spermatozoa that get the advantage. All this leads to a higher probability of conceiving a girl and not a boy. How to increase the probability of having a boy?

There are several ways to increase the probability of conceiving a boy. All of them are associated with facilitating the fertilization of a female egg. After all, the faster your sperm reach the uterus, the more likely it is that a boy will be born, not a girl.

First, your girl must accurately calculate the time of maturation of her egg, in order to conceive a boy on this day. Here it is important not to make a mistake with the day. How do I do this? It is necessary that the girl for three cycles every day measured the temperature (preferably rectally). The peak temperature falls on ovulation, so if conception occurred on a day – to-day basis, it will be a boy, and if it takes 5-3 days, it will be a girl.

Secondly, it is desirable to do more of what men often do not particularly like to do. I mean the foreplay. For what? For a female orgasm. Have you ever wondered why and why a woman experiences an orgasm? I explain, these most convulsive contractions of female pisi are nothing more than a way to quickly deliver your sperm to the uterus. That is why cheating wives often get pregnant from lovers ( with whom there is an orgasm), and not from husbands (with whom they pretend)

Third, this is dogistyle. Who did not understand gru in Russian: put her cancer! This is also one of the mechanical ways to get your sperm into the uterus easier and faster.

Fourth, do not use lubricants, all sorts of grease and even the saliva at the time of conception of the child. All this interferes with and slows down the work of your sperm.

Fifthly, you can list many other things. Do not smoke – the smoker’s sperm is less mobile, and the cigarettes themselves negatively affect the erection. Don’t use drugs for the same reasons. . In addition, cocaine and opiates cause impotence, and amphetamines reduce sexual desire. Do not use the sauna. If you are more than half an hour in the water, the temperature of which is above 40° C, the number of healthy and mobile spermatozoa decreases. From the sauna, the effect is the same. Do not wear tight underwear made of synthetic fabrics. Because the temperature of the scrotum should be a degree less than the rest of the body.

Synthol, anabolics and other chemicals: the history of bodybuilders

Voluminous, perfectly drawn muscles are what every bodybuilders strives for, regardless of age and gender. However, some athletes simply do not know the boundaries in the process of self-improvement. For example, they use clomid without control. We have made a selection of the most striking examples: be surprised, compare and learn from mistakes.

Bodybuilders: Phillip Jerrod Heath

Phil Heath won the title of “Mr. Olympia” 7 times, standing on the same step with Arnold Schwarzenegger. In 2002, he decided to take up bodybuilding, dramatically gaining weight from 84 to 98 kg, while the percentage of fat did not exceed 6%.

Today, Heath consumes at least 9,500 calories a day and trains a lot, paying special attention to the technique of each exercise. The bodybuilder has a very ambitious goal: he dreams of becoming a ten-time champion of “Mr. Olympia”.

Dorian Yates

Dorian ranks 5th in bodybuilding in terms of the number of championship titles. The athlete’s childhood was difficult, he lost his father early. Having decided to realize himself in bodybuilding, the guy has achieved impressive success. Today, he is considered one of the top bodybuilders in history.

bodybuilders

However, Dorian owes his success not only to training: it is proved that he actively used steroids. The fascination with drugs fatally affected the athlete’s health: after one of the performances, he had to be urgently hospitalized with internal bleeding. Soon after, he had to retire from the sport, today he trains bodybuilders and leads seminars.

Greg Kovacs – bodybuilders

At the end of the 90s, Kovac was considered the most massive bodybuilder: with a height of 1 m 93 cm, he weighed 195 kg in the off-season and 150 kg in the season. The volume was also impressive: chest 178 cm, biceps 64 cm, legs 89 cm. Such parameters provided high places at the championships, but sometimes the man used his achievements for other purposes: Greg had problems with the law, he was charged with extortion.

In 2013, the athlete died of a heart attack. During the autopsy, it was found that the heart was greatly enlarged: the cause could be steroids. This explained the surprisingly rapid growth of muscle mass, although during his lifetime Kovac was not convicted of using drugs.

The main mistakes when trying to get pregnant

Most likely, you have at least one friend who, after getting pregnant, said: “It happened at the exact moment when I stopped thinking about it.” It’s annoying, frustrating, and nerve-wracking, especially when all you want is to have a baby. What prevents you from getting pregnant?

It seems that nothing will work-but your friend is telling the truth. Stress can be one of the main reasons why you can’t get pregnant: high levels of the stress hormone cortisol can negatively affect fertility.

A study of American scientists who followed 400 couples trying to get pregnant found that women with high levels of alpha-amylase (a stress indicator) were 29% less likely to get pregnant than women with a normal indicator.

Experts say that constant stress reduces the production of hormones responsible for a stable cycle.

Relax and try to let go of the situation for a while. Learn to meditate, sign up for yoga.

Mistake #2: Doing too much/not enough

If you’re going to do it – do it right! Many couples believe that if you” save ” sperm and do not have sex for a week, the chances of conception will increase significantly. This is not true. After about a week of abstinence, sperm motility decreases markedly.

For successful conception, doctors recommend having sex every day or every other day for a week before and including the day of ovulation. More frequent sex can negatively affect the ability of sperm to fertilize, and if you do it less often – you can skip the window of conception.

So, if your sex life has long been not as stormy as at the beginning of the relationship, this is a good reason to diversify it.

trying to get pregnant

It would seem that the 21st century is in the yard, but many women still continue to believe in the miraculous power of douching. It seems that everything is logical: with any infection, improper nutrition, the presence of bad habits, the environment in the vagina becomes acidic.

Sperm in such an environment dies and cannot fertilize the egg, so many people use a weak solution of soda to make the environment alkaline and create favorable conditions for conception. But doctors are opposed to this method: soda kills not only harmful microorganisms, but also useful ones, thus violating the natural pH of the vagina.

In addition, douching with soda can exacerbate inflammatory processes and diseases such as erosion and damage to the cervix, which a woman often does not know about without visiting a gynecologist.

If the attempt to get pregnant fails, remember that you can use, for example, clomid, taking it, you increase your chances of pregnancy.

Trying to get pregnant: Don’t blame yourself

Speaking about infertility, we usually believe that the problem is on the part of the woman. But in reality, the responsibility lies equally with both partners.

Doctors say that in 40% of cases of infertility, the cause should be sought from the man, and in another 40% – from the woman. The remaining 20% is compatibility, a combination of both partners. But don’t panic too soon.

Remember that a healthy couple needs from 6 months to a year to successfully conceive.

The most common mistake is the wrong definition of the day of ovulation. In most women, it occurs in the middle of the cycle, but this applies to women with a 28-32-day cycle. Ovulation usually occurs 14 days before the start of menstruation. Therefore, if you have a 24-day cycle, then ovulation will occur on day 10.

If your cycle is noticeably longer, say 42 days, then it can be assumed that you ovulate less frequently, not in every cycle. In this case, as well as if you have an irregular cycle (in this case, ovulation can be both on day 6 and on day 21), or you do not remember when you last had your period, forget these rules.

Another mistake when trying to get pregnant

A lot has already been said on this topic, but it will not be superfluous to repeat it: it is necessary to give up bad habits at least a year before trying to get pregnant.

Why do women continue to drink alcohol and smoke, knowing how harmful this affects the ability to conceive? Doctors around the world warn: the first trimester is the most important in the formation of the child’s body. There is no amount of alcohol that is safe for him.

But some expectant mothers, drinking alcohol in the early stages, do not yet know that they are pregnant. Therefore, if you do not protect yourself, in relation to alcohol and cigarettes, act as if you are already pregnant-simply, do not use it or at least reduce it to a minimum.

Clomid ovulation

The main purpose of Clomid is to induce ovulation in women who do not ovulate or do not ovulate regularly. Between 70 and 80 percent of women taking Clomid will ovulate during the first cycle of treatment. Of course, ovulation is only the first step. Your chance of getting pregnant within a few cycles is approximately 35 percent. If you haven’t gotten pregnant in six months, it’s time to switch to another treatment.

What are the chances that Clomid will work in the first month?

Depending on which studies you refer to, the probability of conception within a single cycle of Clomid treatment is between 7 and 30 percent. The effectiveness of Clomid varies depending on the cause of infertility.

Keep in mind that those who do not have fertility problems are about 25 percent more likely to get pregnant in any given month. If you don’t get pregnant in a month, don’t panic. The need for more than one cycle is common.

What are the chances of getting pregnant after many cycles on clomid?

A literature review published in the journal Human Reproduction reviewed several studies on clomid. In total, Clomid success rates for more than 5,000 women were included. In this study, they found that:

  • 73 percent eventually ovulated on clomid
  • 36 percent eventually reached pregnancy
  • 29 percent gave birth

The birth rate is lower than the pregnancy rate due to miscarriages. Clomid does not seem to increase the risk of miscarriage.

clomid ovulation

Other studies have reported that when using Clomid, the percentage of successful pregnancies is between 30 and 40 percent. Again, the birth rate will be lower due to pregnancy loss.

However, the success of Clomid (clomid ovulation) also depends on why you can’t get pregnant. Clomiphene citrate may work well for people with ovulation problems. But what if ovulation isn’t a problem?

Another study, conducted in Scotland, looked at success rates for couples who were found to have infertility. The couples were randomly assigned to one of three groups: “wait-and-see”, clomid-only treatment, or clomid with IUI. The most effective treatment group was the IUI plus Clomid group, which achieved a 22 percent fertility rate. The clomid – only treatment group did the same with couples who received no treatment at all.

Does the day you start treatment with clomid matter?

Clomid is taken for five days. Treatment can be started as early as the 2nd day of the menstrual cycle or as early as the 5th day. However, most doctors either prescribe clomid on days 3, 4, 5, 6, and 7, or take it from you on days 5, 6, 7, 8, and 9.

Does it matter which protocol your doctor chooses? Yes and no. In order to cause ovulation, treatment is carried out from day 5 to day 9. If your doctor wants to” improve ” ovulation, you will probably take Clomid on days 3 to 7.

However, when it comes to pregnancy and ovulation success rates, studies have found no advantages or disadvantages.

Your chances of getting pregnant are the same, regardless of which protocol your doctor prefers to start taking Clomid.

Remember that while you may be mostly familiar with clomid treatment and possibly IVF, there are actually many more infertility treatment options that you should consider. Always talk to your doctor if you’re concerned about the next step or if Clomid isn’t working as well as you hoped.

The likelihood of pregnancy after a long abstinence

Studies have shown that in the absence of ejaculation for several days, the number of spermatozoa increases significantly. It seems that the answer about the benefits of abstinence is found. But in practice, it is proven that couples with regular sex have the same chances of successful conception.

It turns out that short-term abstinence (up to 5 days) actually increases the number of spermatozoa in the sperm, but reduces their quality, or rather, mobility. Then there is another question, which is better: quantity or quality? Again, the conducted research will help, which showed:

  • Daily sex – 25% of couples achieve pregnancy;
  • Intimate life in a day – 22% positive result;
  • Sex no more than once every seven days – success at conception 10%;
  • Sexual contact once a month – over time, the onset of infertility is possible.

It should be concluded that the chances of successful conception are much higher in those who have daily sexual intimacy. Therefore, the question of abstinence will apply only to those couples who make love regularly. Such people will benefit from three days of rest and increase the chances of a positive result.

Men’s long abstinence

Successful fertilization depends on the quality of the sperm. Sometimes, wanting to have a child, couples do not get out of bed. Such sexual activity greatly reduces the possibility of pregnancy. Ejaculation is daily, but the quality characteristics of the sperm deteriorate, as it matures at a certain time.

long abstinence

Spermatozoa must gain energy to enter the uterus and perform fertilization. How much you need to refrain a man in front of the child’s conception? Three days of abstinence is enough for the seed to ripen. You should always comply with the measure, especially in the period of pregnancy planning. It is important not to overdo it and not to aggravate the situation instead of the desired result.

Long-term sexual abstinence will negatively affect men’s health. Libido will decrease, and seminal fluid will deteriorate.

For some reason, it is believed that before conception, it is recommended to reduce the number of sexual contacts only for men. But it is also necessary and even useful for ladies to limit their sexual life. And there are good reasons for this:

  • Sexual activity with frequent orgasms changes the position of the uterus. This becomes a difficult obstacle to fertilizing the egg, as it is difficult for the sperm to reach the goal.
  • Some women have chronic diseases. In most pathologies, inflammatory processes develop, and this reduces the success of fertilization. During the period of abstinence, inflammation is stopped, a certain sanation is carried out.
  • The sexual needs of the fairer sex are different from those of men, and many women do not need daily sexual contact. Therefore, the avoidance of sexual intercourse is quite consistent with the biological rhythms and female physiology.

IMPORTANT! It is necessary to eliminate the psychological pressure if there were unsuccessful attempts to conceive.

It should be noted that the main condition for fertilization is ovulation, the duration of which is not more than 48 hours. If you abstain for too long, you can skip the exit of the egg from the follicle and conception will not occur.

How many days do you need to abstain before conception?

It is impossible to determine exactly how much a man should abstain before conception. It all depends on the male body and the time of maturation of spermatozoa.

There is an opinion of doctors that you should refrain from sexual contact for two or three days. Since during this period, the number of germ cells is already fully restored.

A longer time leads to stress, provoked by a strict restriction.

Studies of women’s needs have shown that abstinence is useful for them for no more than five days. During this time, the woman will not only rest, but also eliminate possible inflammation, normalizing the microflora in the vagina.

The consequences of prolonged abstinence for men

Prolonged avoidance of sexual intimacy is harmful for both partners, especially for men. Long abstinence reduces the desire, weakens the erection and significantly worsens the quality of sperm.

In addition, a violation of the rhythm of sexual life leads to serious consequences of a neurotic nature. There may be outbreaks of aggression and irritability.

For men of mature age to refrain from intimacy, in general, is harmful. Lack of sexual activity can lead to loss of potency. Male power will fade due to the lack of its use.

Clostilbegyt (clomiphene) and pregnancy – what you need to know

Clomiphene citrate (Clostilbegit, Clomid, and other trade names) is a fertility drug that has been used since the 1950s. Dr. mark P. Leondires of the Association of reproductive medicine of Connecticut claims that the drug was originally used for the treatment of breast cancer because it has anti-estrogenic properties. However, clomiphene has also been found to help induce ovulation, and there is a long and close association between it and pregnancy. As a result, it has since been used as a drug to stimulate natural ovulation in women who want to get pregnant.

In what cases can clomiphene help you get pregnant?

When it comes to clostylbegitis and pregnancy, who can take the drug and under what conditions?

Polycystic ovary syndrome

Doctors usually recommend clostilbegyt for the treatment of disorders of ovulation due to polycystic ovary syndrome (PCOS).

Infertility in violation of the menstrual cycle or ovulation

In addition, it can also be used to stimulate ovulation in women with unexplained infertility – in the event that, despite the normal physical condition and good laboratory results, it is not possible to conceive a child. Clomiphene is also sometimes used in combination with metformin (Glucophage, Siophor, and other trade names), a drug commonly used to regulate insulin levels, which can further promote ovulation.

In the case of assisted reproductive technologies

Clomiphene can also be used before applying various reproductive technologies to achieve pregnancy, including artificial insemination techniques to increase the chances of pregnancy.

What is the percentage of successful pregnancies when using clomid?

Although this drug is medically approved, and there is a long-known and close relationship between clomiphene and the onset of pregnancy, there is no conclusive evidence of its effectiveness for every woman. If you are trying to get pregnant, you will probably want to know if taking clostylbegit will help you to stimulate ovulation and conceive a child.

Some studies show that treatment with clomiphene in women with ovulation problems can lead to the fact that in most of them (about 80%) the egg is released from the ovaries during the first cycle of taking the drug.

However, ovulation does not mean pregnancy. The chances of getting pregnant during the first cycle are only 30%. And yet, this is almost the same as the usual chances of conceiving a child (25%) in couples who do not have fertility problems. Almost half of the couples treated with klostilbegit, it is possible to conceive during the first six months.

Therefore, you should not be disappointed if you do not get pregnant in the first month of treatment. Treatment with clomiphene is usually limited to 6 consecutive months.

How to get pregnant quickly on clomiphene?

There is some connection between taking clomiphene and pregnancy, as this drug may be effective for some women who want to conceive a child. But the question arises, how quickly to take advantage of this?

  • Get the recipe – It is necessary to obtain a doctor’s prescription for the purchase of Clostylbegite or another analog. However, before the doctor writes a prescription, he will first evaluate how appropriate it is. Women who have been trying to get pregnant for less than a year may be advised to wait until treatment begins.
  • You can save money by buying more affordable analogues – Such medications are not covered by insurance, and it may take several procedures before the attempt to conceive a child is successful. Instead of buying the brand Clomid or Clostylbegit, you can save money and request a prescription for more affordable analogues.
  • Take the drug as prescribed – Tablets clostilbegyt or clomiphene is usually taken from the third to the seventh day of the menstrual cycle. However, some doctors may advise taking them on the fifth or ninth day of the cycle. It is important to remember that the 1st day of the cycle is the day when true menstrual bleeding (menstruation) begins, and not daub (light spotting).
  • No need for a daily ultrasound – Your doctor may suggest you to follow the effect of receiving clomiphene for ovulation, every day of the ultrasound examination. This procedure does not guarantee that pregnancy will occur. So, this is just an expensive way to monitor, and you can opt out of it to save money.
  • Sex every other day – Starting from the seventh day of the cycle, you can plan sexual acts every other day, so that spermatozoa have time to form in the partner’s body. Avoid having more frequent sex, as this can reduce your chances of getting pregnant.
  • Make sure to start ovulating with a test – To check whether ovulation has started, you can use a special test for this. You can buy it without a prescription. He is able to show that it is time for conception. If the ovulation test is positive, sexual intercourse should continue for two consecutive days. After that, you should return to the normal schedule.
  • Check if you are pregnant – On the 28th day or later, with the help of a home pregnancy test, you can check how successful the treatment is. You don’t have to wait too long to find out!

Negative consequences from trying to get pregnant with Clostilbegyt

Although there is a link between taking Clostylbegit and pregnancy, side effects may occur when using it, and they should be given special attention.

Minor side effects

Like all other medications, clostylbegit can cause some side effects. These include abdominal pain and swelling, weakness, nausea, vomiting, insomnia, blurred vision, fatigue, headache, depression, and weight gain. Some women may develop ovarian cysts.

The birth of twins

Women who are treated with fertility drugs have a 10% chance of having twins. This is due to the release of more than one egg per cycle as a result of drug stimulation of ovulation. In rare cases, triple or even larger multiple pregnancies also develop, which can increase the risk of complications such as miscarriage.

Clostilbegyt

Emotional aspects

Infertility treatment can be a source of emotional stress due to waiting and the lengthy treatment process. Therefore, a woman will need the support of a partner or friend to go through all the doctor’s examinations and follow-up steps related to treatment.

Ovarian hyperstimulation syndrome

The use of clomiphene citrate together with other powerful fertility drugs sometimes leads to the development of ovarian hyperstimulation syndrome (OHSS). This condition is characterized by bloating and increased body weight. Some women also experience shortness of breath, pelvic pain, dizziness, nausea, and vomiting. This condition occurs when the ovaries produce multiple eggs. At the same time, they become several times larger than their normal size, releasing fluid into the abdominal cavity. Usually, no treatment is required, although in some cases, hospitalization may be required for monitoring.

Ovarian cancer

While this is a concern, research shows that using fertility drugs does not necessarily increase the risk of ovarian cancer, even if the course takes more than 12 months.