Clostilbegyt (clomiphene) and pregnancy – what you need to know

Clomiphene citrate (Clostilbegit, Clomid, and other trade names) is a fertility drug that has been used since the 1950s. Dr. mark P. Leondires of the Association of reproductive medicine of Connecticut claims that the drug was originally used for the treatment of breast cancer because it has anti-estrogenic properties. However, clomiphene has also been found to help induce ovulation, and there is a long and close association between it and pregnancy. As a result, it has since been used as a drug to stimulate natural ovulation in women who want to get pregnant.

In what cases can clomiphene help you get pregnant?

When it comes to clostylbegitis and pregnancy, who can take the drug and under what conditions?

Polycystic ovary syndrome

Doctors usually recommend clostilbegyt for the treatment of disorders of ovulation due to polycystic ovary syndrome (PCOS).

Infertility in violation of the menstrual cycle or ovulation

In addition, it can also be used to stimulate ovulation in women with unexplained infertility – in the event that, despite the normal physical condition and good laboratory results, it is not possible to conceive a child. Clomiphene is also sometimes used in combination with metformin (Glucophage, Siophor, and other trade names), a drug commonly used to regulate insulin levels, which can further promote ovulation.

In the case of assisted reproductive technologies

Clomiphene can also be used before applying various reproductive technologies to achieve pregnancy, including artificial insemination techniques to increase the chances of pregnancy.

What is the percentage of successful pregnancies when using clomid?

Although this drug is medically approved, and there is a long-known and close relationship between clomiphene and the onset of pregnancy, there is no conclusive evidence of its effectiveness for every woman. If you are trying to get pregnant, you will probably want to know if taking clostylbegit will help you to stimulate ovulation and conceive a child.

Some studies show that treatment with clomiphene in women with ovulation problems can lead to the fact that in most of them (about 80%) the egg is released from the ovaries during the first cycle of taking the drug.

However, ovulation does not mean pregnancy. The chances of getting pregnant during the first cycle are only 30%. And yet, this is almost the same as the usual chances of conceiving a child (25%) in couples who do not have fertility problems. Almost half of the couples treated with klostilbegit, it is possible to conceive during the first six months.

Therefore, you should not be disappointed if you do not get pregnant in the first month of treatment. Treatment with clomiphene is usually limited to 6 consecutive months.

How to get pregnant quickly on clomiphene?

There is some connection between taking clomiphene and pregnancy, as this drug may be effective for some women who want to conceive a child. But the question arises, how quickly to take advantage of this?

  • Get the recipe – It is necessary to obtain a doctor’s prescription for the purchase of Clostylbegite or another analog. However, before the doctor writes a prescription, he will first evaluate how appropriate it is. Women who have been trying to get pregnant for less than a year may be advised to wait until treatment begins.
  • You can save money by buying more affordable analogues – Such medications are not covered by insurance, and it may take several procedures before the attempt to conceive a child is successful. Instead of buying the brand Clomid or Clostylbegit, you can save money and request a prescription for more affordable analogues.
  • Take the drug as prescribed – Tablets clostilbegyt or clomiphene is usually taken from the third to the seventh day of the menstrual cycle. However, some doctors may advise taking them on the fifth or ninth day of the cycle. It is important to remember that the 1st day of the cycle is the day when true menstrual bleeding (menstruation) begins, and not daub (light spotting).
  • No need for a daily ultrasound – Your doctor may suggest you to follow the effect of receiving clomiphene for ovulation, every day of the ultrasound examination. This procedure does not guarantee that pregnancy will occur. So, this is just an expensive way to monitor, and you can opt out of it to save money.
  • Sex every other day – Starting from the seventh day of the cycle, you can plan sexual acts every other day, so that spermatozoa have time to form in the partner’s body. Avoid having more frequent sex, as this can reduce your chances of getting pregnant.
  • Make sure to start ovulating with a test – To check whether ovulation has started, you can use a special test for this. You can buy it without a prescription. He is able to show that it is time for conception. If the ovulation test is positive, sexual intercourse should continue for two consecutive days. After that, you should return to the normal schedule.
  • Check if you are pregnant – On the 28th day or later, with the help of a home pregnancy test, you can check how successful the treatment is. You don’t have to wait too long to find out!

Negative consequences from trying to get pregnant with Clostilbegyt

Although there is a link between taking Clostylbegit and pregnancy, side effects may occur when using it, and they should be given special attention.

Minor side effects

Like all other medications, clostylbegit can cause some side effects. These include abdominal pain and swelling, weakness, nausea, vomiting, insomnia, blurred vision, fatigue, headache, depression, and weight gain. Some women may develop ovarian cysts.

The birth of twins

Women who are treated with fertility drugs have a 10% chance of having twins. This is due to the release of more than one egg per cycle as a result of drug stimulation of ovulation. In rare cases, triple or even larger multiple pregnancies also develop, which can increase the risk of complications such as miscarriage.


Emotional aspects

Infertility treatment can be a source of emotional stress due to waiting and the lengthy treatment process. Therefore, a woman will need the support of a partner or friend to go through all the doctor’s examinations and follow-up steps related to treatment.

Ovarian hyperstimulation syndrome

The use of clomiphene citrate together with other powerful fertility drugs sometimes leads to the development of ovarian hyperstimulation syndrome (OHSS). This condition is characterized by bloating and increased body weight. Some women also experience shortness of breath, pelvic pain, dizziness, nausea, and vomiting. This condition occurs when the ovaries produce multiple eggs. At the same time, they become several times larger than their normal size, releasing fluid into the abdominal cavity. Usually, no treatment is required, although in some cases, hospitalization may be required for monitoring.

Ovarian cancer

While this is a concern, research shows that using fertility drugs does not necessarily increase the risk of ovarian cancer, even if the course takes more than 12 months.

Coronavirus and pregnancy: what is the danger of COVID-19 for expectant mothers

Scientists believe that the coronavirus attacks people with weakened immune systems. These include pregnant women. The body of the future mother works for two: for herself, and for the baby. In normal times, doctors recommend that women “in a position” to monitor their health as much as possible and not expose their body to additional stress. And during the coronavirus epidemic, expectant parents need to be especially careful. How does COVID-19 (danger of COVID-19!) affect pregnancy and what happens if the virus is detected in a pregnant woman? Is it possible not to observe the self-isolation regime and go to a medical institution? Should I be afraid for my health?

What is the danger of coronavirus during pregnancy

According to official data, infection of a pregnant woman with coronavirus can lead to premature birth and cesarean section. Moreover, the risk of death during childbirth or abortion increases.

Doctors strongly recommend that pregnant women self-isolate for the entire period of quarantine and contact their relatives and friends only with the help of modern means of communication.

How does coronavirus affect pregnancy and the baby

There is no exact data on the effect of COVID-19 on the unborn child. Scientists have not yet found out what malformations the virus provokes. However, the severe course of the disease in the mother can lead to the death of the fetus.

danger of COVID-19

WHO (World Health Organization) in its guidelines highlights the possible impact of drugs used in the treatment of coronavirus. Their toxic effects can lead to pathologies of fetal development.

The danger of Covid-19 during pregnancy in the 1st trimester

In the guidelines for the prevention, diagnosis and treatment of coronavirus, there is a separate item “Obstetric tactics for COVID-19”. It says that obstetric tactics are determined by the condition of the future mother and fetus, as well as the duration of pregnancy. In the 1st trimester (up to 12 weeks), if the patient carries the coronavirus very hard, it is possible to terminate the pregnancy after the end of treatment. This is due to the toxic effect of drugs on the child.

However, to terminate a pregnancy in the early stages of coronavirus can also be during the progression of the disease, if the life of the future mother is at risk (respiratory failure progresses, bleeding occurs, the fetus dies or other complications occur). In this case, the woman is carried out by caesarean section.

Whether pregnant women comply with the quarantine?

Yes, because pregnant women are at risk. The main reason is that the effect of the pathogen on the unborn child has not been studied. Therefore, all pregnant women are advised to observe the strictest quarantine and to have as little contact with other people as possible.

The danger of Covid-19 is no joke! Many couples are planning a pregnancy. To do this, many women buy clomid online. However, during the coronavirus period, doctors recommend that attempts to conceive a child be abandoned until the epidemiological situation stabilizes and that this issue be returned to after the quarantine measures are lifted.

Does ovulation happen before menstruation

Does ovulation happen before menstruation – this question torments a lot of women. Fertilization of the egg is possible only if ovulation occurs before the cycle. The best time for pregnancy is in the middle of the menstrual cycle. Ovulation before menstruation occurs, but very rarely, in such cases, two eggs mature, and a woman can give birth to twins. In this case, this may occur either due to the onset of repeated ovulation, or due to a failure of the cycle.

How long before the appearance of bloody discharge should ovulation occur

After a follicle has formed in the ovary, the inner lining of the uterus begins to increase. After that, the egg enters the fallopian tube, this moment comes about two weeks after menstruation, until the 16th day before it. These processes are extremely important for the intended fertilization of the egg.

After the egg enters the body of the uterus, spermatozoa also penetrate here, also through the fallopian tube, only on the other side. Only after the meeting of the egg with the sperm is fertilization performed. If this does not happen, the egg is excreted by the body outside, that is, menstruation occurs. It turns out that you can get pregnant a week before your period, although the chances are not so great. 5 days before their onset – even less.

Gynecologists believe that the optimal cycle of menstruation is 28 days, the time for conception is the middle of the cycle. At this point, everything is in place for a successful fusion of the egg with the sperm.

How long does the ovulation period last

Those women who plan to conceive, keep a calendar of ovulation dates. And this is correct: in order for conception to occur for sure, you need to know the period and duration. Based on the total duration of menstruation, the ovulatory period occurs:

  • with a cycle of 21 days for 5-9 days;
  • with 25 after 9-13 days;
  • with 30 for 16-20 days;
  • with 35 for 19-23 days.

Provided that the monthly regularity does not differ, then it is extremely difficult to correctly calculate the day of the onset of the ovulatory period. In this case, it is better to use other, more accurate methods of deduction. It lasts for each woman in different ways.

Answering the question whether there can be ovulation before the most monthly, we come to an unambiguous – in most cases it can not. It happened that women got pregnant before their periods – such cases are very rare.

Gynecology knows cases when women get pregnant on the day of the cycle, which is considered completely zero. This is explained by changes in the hormonal background, this happens against the background of emotional state, stress and other factors.

Due to severe stress, the menstrual cycle can shift, affecting the period of ovulation. As a result, two ovaries are able to secrete an egg. Not necessarily on the same day, it can happen on different days, and pregnancy will occur during menstruation.

Can it come sooner

In cases where a woman’s cycle is 35 days, even if she is absolutely healthy and her monthly periods come regularly, the release of a mature egg may occur earlier. And the fertile period-later for a week or a little longer.

This can provoke:

  • Hormonal disorders in the body.
  • Emotional overstrain and stress.
  • Weakened immune system.
  • Exacerbation of chronic diseases.
  • Violation of metabolic processes Overeating or, conversely, starvation.
  • Sudden climate change.
  • Heavy physical activity

The fertile period may also shift due to the withdrawal of contraceptive drugs, after an abortion or due to a miscarriage.

Does the absence of ovulation before pregnancy mean conception

You can conceive a child only when a woman has matured an egg. The absence of ovulation indicates that this process does not occur in the body of the expectant mother. This means that there can be no question of any pregnancy. In such cases, you need to go to the gynecologist and find out the cause of what is happening. The root cause of this may be a hormonal imbalance.

ovulation before menstruation

You can correct it with a specially selected therapy. If the cause cannot be established, doctors resort to radical methods, for example, during the period of alleged ovulation, the patient is injected with a drug that causes the formation and maturation of the follicle with the further release of the egg.

Is it possible to fertilize an egg after ovulation

No, a miracle, in this case, will not happen. A day after ovulation, women have a period that gynecologists call absolute infertility. For those who do not know the answer to the question of whether there can be ovulation before menstruation, we explain the essence of what is happening during the ovulatory period.

Ovulation divides the monthly cycle into two parts. The first is the phase of follicle maturation (duration, on average, 6-9 days). The second is the yellow body phase, the duration of this period lasts, depending on the cycle, and is, on average, 14 days. The second refers to the period of absolute infertility.

Pregnancy does not occur because a mature and ready-to-fertilize egg lives only 24 hours. Sometimes it can live even less. After it begins to collapse.

Can the ovulatory period occur before menstruation

The moment when the egg enters the uterus depends on the hormonal level and the duration of the follicular phase. In some young girls, these processes are very slow. Ovulation and pregnancy before menstruation are possible, due to the fact that the first phase becomes a little longer than usual. The primary cause of this may be a deficiency of the hormone estradiol. The moment of ovulation in such cases falls on the day of the beginning of menstruation, and the cycle itself should move.

Menstruation can not begin at the time of rupture of the follicle, because here comes the luteal phase, which lasts 14 days plus / minus 2 days.

If the ovulation period occurred at the beginning of the cycle and at this point the couple had unprotected contact, then the probability of fertilization remains high. In women in such cases, it is believed that ovulation occurred just before menstruation. In fact, the cycle, or rather its duration, has increased due to the follicular phase.

Probability of fertilization a week before the cycle

If pregnancy is not included in the family plans, then you need to be protected before the cycle constantly, even for a week. Although ovulation can not occur a week before menstruation, there is a chance of fertilization. This applies to young girls and women on the verge of menopause. In medical practice, such cases have happened. The reason for this may be too long periods, irregular cycles or severe stress loads.

The calendar schedule of pregnancy protection in such cases does not work, the probability of unwanted fertilization increases. In cases where the release of a mature egg fell on the period a week before the cycle, the woman must necessarily feel the characteristic symptoms of the fertile phase.

Is there a chance of pregnancy a day or two before the cycle

Many women believe that this is impossible. This statement is false, in fact, there is such a probability, although it is scanty. If a woman is absolutely healthy, then the greatest chances of pregnancy, namely 95%, fall in the middle of the cycle, the chance of fertilization of the egg a day before menstruation is reduced to 1 %, but it still exists. Gynecologists believe that unwanted pregnancies in women occur due to the fact that they simply incorrectly calculate the ovulatory period or because of a violation of the cycle itself.

Can ovulation be more than once

In almost all healthy women, ovulation occurs repeatedly during their lifetime. The regularity of the cycle does not play any role here. The approximate time of the second one is 24 hours or 2/3 days after the first one. The maximum difference is 1/1. 5 weeks in the same cycle. This fact is explained by the fact that both ovaries simultaneously matured eggs. At the time of release, the second hormone level decreases, but the probability of fertilization remains.

In conclusion: ovulation before menstruation

Summing up all the above, it can be noted that even the healthiest representative of the fair sex can have shifts in the ovulatory phase – this is the answer to the main question, which was mentioned above, whether there can be ovulation a week before menstruation, a day or just before them.

Such deviations are temporary, most often the regularity of the cycle is restored by itself. If this is a consequence of pathological changes in the body, then you can not do without the help of doctors.

Methods of ovulation stimulation at home

In gynecology, there are often situations when a woman can not conceive due to the lack of ovulatory periods, i.e. due to anovulation. In such clinical cases, it is necessary to stimulate the maturation and release of the egg. There are many methods to stimulate ovulation at home. But the specific choice is determined by the degree of anovulation. In some cases, you can cope with the problem yourself, using home techniques, and in others you can not do without medical intervention.

When stimulate ovulation at home is needed

If the patient suffers from anovulation, or the egg rarely matures and leaves the follicle, then the stimulation of this process is shown, thanks to which thousands of patients have already managed to experience the happiness of motherhood.

  • Usually, the indications for stimulation are such situations when more than a year of regular sexual relations in the absence of protection do not lead to conception.
  • If the couple is older than 35 years of age, the time during which it is not possible to get pregnant is reduced to six months.
  • Ovulation stimulation at home and even in the clinic is meaningless if there is male infertility.
  • If the patient suffers from tubal obstruction, then stimulation can provoke ectopic fixation of the embryo. Therefore, patients are recommended to undergo laparoscopy beforehand, only after the procedure, in the absence of obstruction, stimulation is allowed.

Methods of stimulating the output of the female cell

Many women repeatedly ask the question of how to stimulate ovulatory processes and how this can be done. First of all, it is necessary to undergo a thorough examination, so that when self-stimulation does not harm your own health. Home stimulation is quite a difficult task, but with a properly thought-out approach, it is quite feasible.

How to stimulate ovulation at home

For stimulation, you can use medications (for example, clomid) and vitamins, herbs and certain nutrition programs, healing mud or essential oil therapy, etc. More recently, the diagnosis of “female infertility” could destroy the happiness and life of many patients, but with the help of stimulating the maturation and release of the egg, such women have a real chance.

Such a measure is ideal in the case of ovarian polycystic disease, as well as for patients with a variety of menstrual disorders, anovulation and other abnormalities. But it should be carried out only after the normalization of thyroid hormones, androgens and prolactin, otherwise the stimulation will be ineffective. In general, there are many methods, so everyone can choose the most convenient option for themselves. Although any choice should be agreed with the doctor, since only he will be able to choose the most appropriate incentive option in each individual case.

Stimulate ovulation at home: Vitamins

One of the most effective methods to stimulate ovulation is vitamin therapy. For the successful maturation and release of the egg, a woman must have a sufficient supply of trace elements and vitamin substances in the body. To achieve this, you need to provide the diet with the necessary nutrition, competently making a daily menu. To begin with, it is worth enriching the body with folic acid, which is so important that when it is deficient, all sorts of intrauterine pathologies occur.

In addition, it is necessary to replenish the necessary content of potassium iodide, for which the diet includes iodized salt. If you decide to take complex vitamin preparations, it is better to choose from those that are recommended for nursing and pregnant women. The diet must include as many vegetables, berries, herbs and fruits as possible. These foods are an important stimulating factor for ovulation. It is also recommended to eat more fish, and it is better to refuse black coffee and tea or drink such drinks very rarely. It is necessary to give up unhealthy habits like alcohol or cigarettes, which have an extremely negative effect on the maturation and output of cells.

Main stages of stimulation

If the drug Klostylbegit is chosen as a stimulant, then its reception falls on the 5-9 day of the cycle, and Puregon or Menogon begin to drink from 2 to 10 days. The exact timing should be set by the doctor depending on the situation. When to start stimulation and how long to continue the procedures or courses depends on the health of the uterus and ovaries, which is determined by ultrasound examination. The doctor periodically prescribes a woman control ultrasound until the follicles grow to 21-25 mm in size. And to avoid the formation of follicular cystic formations or follicular regression, patients are prescribed HCG injections. Such a procedure promotes the launch of ovulatory processes.

If everything goes well, then after 1-1. 5 days after the chorionic injection, the follicle will burst and the female cell will begin to exit. If the ultrasound diagnosis shows ovulation, the patient is prescribed injections of Utrozhestan or Progesterone to further support the yellow ovarian body. When applying Clostilbegyt, as they say patients are often able to achieve conception.

Important! The doctor also takes into account the male factor, so he specifies the specific terms and frequency of sexual intimacy in the process of stimulation. With good spermogram indicators after hCG injection, sexual contacts should be carried out every day or every other day until the end of the ovulatory period.

If a positive result is not achieved after three times the use of Clostylbegit, it is recommended to undergo a more thorough diagnosis and use other therapeutic methods. Before performing stimulation, the patient must pass laboratory tests for syphilis, HIV and hepatitis, smear for microflora and oncocytology, ultrasound diagnostics of the mammary glands, check the patency of the fallopian tubes, etc. The therapist must conclude that the patient is capable of carrying a child.

Contraindications to ovulation stimulation at home

Not all patients can be ovulated. For example, if there are pathological processes in the female body that prevent conception and full-fledged gestation, then stimulation is not carried out. Such pathologies include adhesions in the tubes, tumors of reproductive structures, etc. In addition, do not perform stimulation, if before this 6 times such a procedure did not give any positive dynamics.

Relative contraindications for performing a stimulating procedure include an age exceeding the 35-year limit. This restriction is due to the fact that in such a clinical situation, the probability of giving birth to an unhealthy child with a disability or developmental abnormalities seriously increases.

Coronavirus in pregnant women

Coronavirus in pregnant women: Infection with COVID-19 during pregnancy can affect not only the health of the mother, but also the development of the child, according to obstetricians and gynecologists. So, the coronavirus can affect the slowing of fetal growth, provoke incorrect laying of its vital organs, and also lead to prematurity of the child.

Is coronavirus dangerous for pregnant women?

If a woman has contracted a coronavirus infection in the second trimester of pregnancy, this can lead to a slowdown in the development of the fetus.

At the same time, there is a possibility that the effect of CAVID-19 on the child will continue after the recovery of the expectant mother, the expert believes. “So, in the first trimester, a virus carried by a pregnant woman can affect the growth of the fetus, and in the second — cause a slowdown in the development of the child,” the doctor said.

Coronavirus in pregnant women

According to her, such consequences are associated with respiratory failure – in a woman in the late stages of pregnancy, the stomach presses on the lungs, thus reducing their volume.

In addition, the coronavirus also affects red blood cells (red blood cells that supply the body with oxygen).

“Red blood cells lose the ability to carry oxygen, respectively, the fetus begins to experience oxygen starvation, so automatically slows down and its growth and development»

Coronavirus in pregnant women: facts

Experts believe that only patients who have COVID-19 in moderate to severe forms, and it is during the second or third trimester, should be afraid.

According to the doctor, with this course of the disease, the fetus may be so short of oxygen that doctors — in order to alleviate the condition of the child — often resort to terminating the pregnancy by caesarean section.

In this case, the woman herself often suffers from the inability to breathe, so this operation is also carried out in order to save the life of the woman in labor, Marian Knight, a professor at Oxford University in the UK, previously told the BBC.

Ed Mullins, a British gynecologist at the Queen Charlotte and Chelsea Hospital, also stated that when the fetus develops distress syndrome, childbirth is accelerated artificially. “This is done in order to provide more effective treatment for low oxygen levels in a woman,” the medic explained.

Transmission of the virus

As for the transmission of coronavirus from mother to child in utero, such cases have not yet been recorded. “The fetus is not a direct target for COVID-19. The virus has no proven teratogenic effect (disruption of embryonic development due to external factors) on the fetus. The placental barrier is really good for him. As a rule, children are born healthy».

She added that in order to avoid serious disorders in the body of a pregnant woman and fetus, expectant mothers with coronavirus should be isolated in time and placed under medical supervision. “Remember that stress is the main danger of a successful pregnancy. Do not read unverified news, follow all hygiene measures and be positive, ” the medic said.