Ovarian hyperstimulation syndrome

Ovarian hyperstimulation syndrome is characterized by an increase in the ovaries with the development of numerous cysts (the condition of polycystic ovaries), the accumulation of fluid in the tissues, abdominal cavity and lungs. In 2% of cases, this condition requires immediate hospitalization. The occurrence of ovarian hyperstimulation syndrome is associated with a sharp rise in the level of estrogens (estradiol) under the influence of gonadotropins, which can lead to the rapid development of ovarian cysts.

This disease occurs in 10-20% of cases after ovulation induction, mainly mild and moderate severity. With a mild degree of this syndrome, the ovaries are enlarged to 5 cm in diameter, there is also a slight ascites and weight gain of up to 5 kg. With moderate severity of the syndrome, the ovaries are enlarged from 5 to 12 cm, there is moderate ascites, nausea, vomiting, discomfort in the lower abdomen, and an increase in body weight of more than 5 kg. Severe cases of ovarian hyperstimulation are characterized by an increase in the ovaries, severe ascites, nausea, vomiting, diarrhea, shortness of breath, accumulation of fluid in the lungs, dropsy, blood thickening, and can lead to kidney failure.

ovarian hyperstimulation syndrome

Severe forms occur in young women with irregular rare menstruation, who after the first induction had a condition of polycystic ovaries (more than 15 follicles). Hyperstimulated ovarian syndrome has two phases. The first phase manifests itself from the second to the seventh day after ovulation, and the number of signs of the disease is limited. The second phase occurs after a woman becomes pregnant.

How is hyperstimulated ovarian syndrome treated?

Women with mild to moderate syndrome can stay at home, preferably in bed, strictly controlling the amount of fluid consumed and excreted. If, after the induction of ovulation, a woman has dramatically recovered by 1-1.5 kg, it is advisable to hospitalize such a woman. Severe cases should be treated in hospital conditions, taking into account the condition of the woman.

Prevention

When conducting ovulation induction, it is very important to monitor the reaction of the ovaries to the administration of medications, which can be done using ultrasound. If there is a development of 1-3 follicles up to 18-20 mm in size, such induction can be considered safe. However, with the appearance of 5 follicles or more, as well as with a sharp increase in blood estradiol, it is advisable to stop the induction of ovulation.

Ovulation induction. Part II.

We continue to answer questions related to ovulation induction

How long can the induction of ovulation with clomiphene citrate be carried out?

Induction with this drug can be carried out for 4-6 months. In 40-45% of all women and in 80% of correctly selected women, pregnancy will occur within 6 months. After six months, it is impractical to carry out ovulation induction.

What gonadotropin preparations are used to induce ovulation?

Gonadotropins are hormones that are produced by the pituitary gland, or substances that have a similar effect to pituitary hormones. Modern medicine uses the following gonadotropins to induce ovulation:

  • human menopausal gonadotropin (HMGs)
  • human chorionic gonadotropin (hCG)
  • follicle stimulating hormone (FSH)
  • luteotropic hormone (LH, luteinizing hormone).

What is human menopausal gonadotropin?

Human menopausal gonadotropin is a combination of FSH and LH, mainly created by genetic engineering from mammalian ovarian cells (for example, hamsters). Such combinations have from 60 to 120 units of hormones (depends on the manufacturer). For the first time, FSH and LH were isolated from the urine of menopausal women in 1954, and this combination of hormones was called pituitary human gonadotropins. In menopausal women, the amount of FSH and LH in the urine is increased. The first ovulation induction was performed in 1958, and the first pregnancy after ovulation induction occurred in 1960.

Gonadotropins are most often indicated in cases where the induction of ovulation with clomiphene citrate is unsuccessful, as well as in women with hypothalamic-pituitary factor infertility, when a sufficient amount of FSH and LH is not produced.

Ovulation induction

What is human chorionic gonadotropin?

Human chorionic gonadotropin is produced by the placenta, and it is obtained from the urine of pregnant women. The chemical structure, and therefore the effect, is almost the same with the pituitary gland LH. Since a sharp increase in LH before ovulation contributes to the maturation of the egg, the introduction of hCG before the expected ovulation leads to the rupture of the follicle and the release of the egg.

To get a positive effect with this type of ovulation induction, it is very important to choose the right day of the cycle for the administration of the drug, which many doctors determine using ultrasound and measuring the level of estrogen in the blood. Ovulation occurs within 36-48 hours after HCG administration. This drug is often used to enhance the effects of clomiphene citrate when it is not possible to trace the peak of LH. Since hCG is excreted in the urine, a pregnancy test may be false positive within 10 days after HCG administration.

What are the side effects of using gonadotropins?

Up to 33% of all pregnancies that occur after the induction of ovulation by gonadotropins are multiple (70% are twins, 30% are triplets). Therefore, the rate of premature birth, and hence the mortality rate of newborns, is increased. A dangerous side effect is ovarian hyperstimulation syndrome (when using hCG, this syndrome is less common than when using other drugs for ovulation induction, in this case we are not talking about clomid and its generics). Other side effects are swelling and soreness of the mammary glands, bloating, abdominal pain, mood changes.

Unlike IVF, the level of fetal malformations after ovulation induction does not exceed the level without ovulation induction. Ectopic pregnancies occur more often after ovulation induction (5-8% of cases compared to 1-2% of cases in the general population of women). Miscarriages are observed in 15-21% of women. Pregnant women after ovulation induction are more likely to suffer from hypertension of pregnant women, and the frequency of placental abruption in such women is increased.

Review: The drug Clomid is safer than tamoxifen

Good day to all sports fans. I would like to share with you a review about the antiestrogenic drug Clomid from Balkan Pharmaceuticals (I used it). The review will clarify the issue of using clomiphene to raise the level of natural testosterone in post-course therapy, so it is designed for a very narrow circle of those who understand what they are doing and for what. In this review, I will try to tell you why clomid is a little better than tamoxifen, based on personal feelings from taking both.

Clomid from Balkan Pharmaceuticals costs about $42 for a blister of 20 tablets of 50 mg. The cost of clomid is three times higher than that of tamoximed from the same manufacturer. And it’s not so easy to buy clomid. If tamoxifen from Ebeve can be found in most pharmacies in any city, then Balkan Pharmaceuticals must be purchased only online.

At the top of any blister is the date of final use and a verification code by which you can verify the authenticity of the products.

drug Clomid

By itself, the Clomid tablet has the same size and shape as most of the drugs from this manufacturer. A square white tablet has a dividing ribbon, but in the case of clomid it is not particularly needed, since 50 mg is a fairly low dosage.

We turn to the action of the drug and the question of why it is a little better than tamoxifen. Both of them perfectly bind estrogens and increase testosterone. All the arguments of clomid supporters about blocking in the pituitary gland, hypothalamus and testicles are completely untenable, so the same effect of tamoxifen has been repeatedly proven. Clomid is a little better, but not this.

The advantage of clomid is that it is not so toxic and has absolutely no side effects, because it is a newer drug. From prolonged use of tamoxifen, vision still drops a little. Clomid is devoid of this side effect as well as possible migraines. I took clomid for a month and never had any side effects.

In general, I recommend not saving on health and using clomid for post-course therapy.

Ovulation induction

What is ovulation induction?

Ovulation induction is an artificial stimulation of the egg maturation process with the help of medications.

What are the indications for ovulation induction?

Ovulation induction is carried out according to strict indications, since the drugs used for this have many serious side effects in women of certain categories:

  • For the treatment of amenorrhea in some cases
  • To stimulate ovulation in women with anovulatory cycles
  • To regulate the cycle in women with irregular menstrual cycles
    (oligomenorrhea)
  • To obtain several eggs in the ovaries of women preparing for IVF (in vitro fertilization) or intrauterine insemination (superovulation).

Healthy women with regular menstrual cycles are not recommended to carry out ovulation induction.

What methods can determine the presence of ovulation?

There are several methods for determining ovulation. Ovulation tests are becoming more popular due to the ease of implementation. They are based on determining the level of LH in a woman’s urine using special strips. The growth and peak of LH levels is observed 32-36 hours before ovulation. Usually, this test is used 2-3 days before the expected ovulation (in women with a 28-day cycle – from 12 to 15 days). In women with irregular cycles, the test should be used from the 11th to the 20th day of the cycle. Ovulation in such women can be confirmed within 5 days in 85% of cases, and within 10 days in 95% of cases. Sometimes ovulation may be absent, which happens normally, however, if ovulation is absent for 2-3 cycles, you need to consult a doctor.

Another method of determining ovulation is ultrasound. Ovulation usually occurs with a follicle size of 1.8‑2.5 cm. This method is more reliable if several ultrasounds are performed in the middle of the cycle every other day. The same method is used by many doctors to control ovulation in infertility clinics. A less common method is an endometrial biopsy with histological examination, which is performed the day before the expected menstruation. This method also allows you to determine the readiness of the endometrium for possible implantation of the fetal egg. Some doctors suggest measuring the level of LH and estradiol in the blood for several days of the cycle. Less and less often women use basal body temperature measurement, since this is not the most reliable method for determining ovulation.

Other questions about ovulation induction in women

Is it possible to use ovulation induction in women who have borderline ovarian tumors removed?

According to new research, it is considered safe to conduct ovulation induction in women after removal of borderline ovarian tumors.

What are the methods of ovulation induction?

Ovulation induction is carried out by one or a combination of several medications, which include clomiphene citrate, FSH, hCG, MGH (human menopausal gonadotropin), bromocriptine, cabergoline, gonadotropin-releasing hormone and its analogues, LH and a number of others.

What are the indications for clomiphene citrate induction?

There are not so many indications for ovulation induction, although many doctors have been abusing this method recently. Induction is indicated for women with rare menstruation or lack of menstruation, those who cannot find out the cause of infertility, with moderate endometriosis, or according to the requirements of the women themselves. The standard dose is 50 mg, for 5 days at the beginning of the cycle. The level of ovulation, pregnancy and the outcome of pregnancy are the same if induction is started on the 2nd, 3rd, 4th or 5th day of the cycle. The doctor should monitor the effectiveness of induction. This can be done by ultrasound, measurement of basal body temperature, determination of the level of estrogen in the blood.

about ovulation induction

When does ovulation occur after the use of clomiphene citrate?

Ovulation occurs most often 5 days after the last dose of clomiphene citrate is administered, however, in many women ovulation can occur from 10 to 23 days of the cycle, so in such cases it is important to monitor the development of follicles using ultrasound.

What are the side effects of using clomiphene citrate that can hinder pregnancy?

Since clomid is an antiestrogenic drug, it can cause inferiority of cervical mucus, which is very important in the fertilization process, and create a barrier to sperm. Even with successful ovulation, such women may have difficulty conceiving due to the artificial cervical factor of infertility created by doctors. Therefore, to control the quality of cervical mucus, experts recommend conducting a postcoital test in the first half of the cycle after each induction with clomiphene citrate. Another negative result of using clomiphene is a decrease in the quality of the endometrium: it becomes thin and of poor quality for successful implantation of the fetal egg. Some side effects are associated with the occurrence of hot flushes (10% of cases), visual impairment, vaginal dryness, hyperstimulated ovarian syndrome. In 10% of cases, there is a double pregnancy (twins). Some women may experience the growth of ovarian cysts, so before conducting a course of ovulation induction, it is necessary to conduct an ultrasound of the ovaries. Insufficiency of the luteal phase is also not a rare side effect when using clomid (observed in 50% of cases).

When is ovulation induction with clomiphene citrate contraindicated?

Induction of ovulation with this drug is contraindicated in the presence of ovarian cysts, pregnancy, liver diseases.

To be continued

What vitamins are needed to get pregnant quickly?

Get pregnant quickly? In this article, questions will be considered about whether it is possible to bring the onset of pregnancy closer with the help of additional means.

How to get pregnant quickly?

Before an important life stage – bearing and giving birth to a child – a woman must undergo a medical examination. It includes examination and delivery of tests. Experts advise to do the same to a man. This is necessary in order to eliminate the risk of infectious diseases, possible future pathologies of the fetus, to receive treatment. The expectant mother should be sure that nothing threatens her health, be observed by specialists in case of chronic diseases.

Wondering what to do to get pregnant quickly, a man and a woman should not only be examined by specialists. Nutrition and lifestyle also have an impact on the reproductive activity of the body. So, for the sake of the health of the unborn baby and a calm pregnancy, it is worth giving up bad habits, expanding the diet, including all the necessary vitamins and minerals, resting more, trying to avoid stressful situations and emotional stress. If the future mother and father follow these recommendations, then the chances of an early pregnancy increase significantly.

What vitamins should I take?

Essential vitamins for women’s and men’s health can be obtained from natural food. So, it is necessary to include in the diet dishes from meat, cereals, vegetables, fruits, fresh dairy products – they are a source of carbohydrates, fats, proteins and micronutrients. The food should be full and varied. You should avoid snacking on the go, eating fast food. It is also necessary to adjust the water balance in the body. In order to get the right amount of liquid, you should drink at least two liters of water a day.

get pregnant quickly

What vitamins should I take to get pregnant quickly? The composition of such combined preparations includes, at least, folic acid, vitamins D and E. Experts advise taking them once a day, except folic acid – these vitamins should be drunk one tablet 3 times a day.

The body is enriched with useful substances, the hormonal balance returns to normal, the nervous system of the unborn child is protected from various disorders. In addition, if a woman takes care of herself and adheres to proper eating habits, she feels a surge of strength, her condition improves, which also contributes to a faster onset of pregnancy and the ability to safely carry a child.

Pills for pregnancy

What pills to take to get pregnant quickly? Are there drugs that enhance sexual function? Yes, however, you should not try to purchase and take them yourself, without the permission of a doctor. Only after the specialist examines the results of the tests from the woman, he can prescribe treatment. Otherwise, a woman risks seriously harming her health and even provoking infertility.

Everyone knows that the onset of the ovulation period promotes conception. Therefore, doctors prescribe drugs that stimulate this process and bring the onset of pregnancy closer.

Stimulation of pregnancy with the help of medications is a very difficult issue. Only a doctor can prescribe effective infertility treatment or help bring the onset of pregnancy closer, and it should be remembered that drugs (for example clomid (clomiphene)) that stimulate reproductive activity can have unpleasant side effects.

Ovulation stimulation: indications, possible complications

Unfortunately, some women have difficulties with the production of female germ cells, or with their normal maturation and subsequent fertilization. To solve this problem, such a procedure as ovulation stimulation was developed.

Thousands of married couples today face the problem of conceiving a child, which is due to various negative factors. The absence of ovulation, obstruction of the tubes, abnormalities of the development of reproductive organs – this is not a complete list of reasons that prevent pregnancy. A huge number of women suffering from infertility managed to become happy mothers only with the help of the achievements of modern medicine.

Indications for ovulation stimulation

Hormone therapy aimed at stimulating ovulation is prescribed to women in the following cases:

  • with infertility of unclear genesis (if a woman has no objective reasons preventing pregnancy, but even with regular sexual activity throughout the year, conception does not occur);
  • with hormonal insufficiency that cannot be corrected by other means;
  • when using assisted reproductive technologies that require the collection of eggs from the ovaries (in vitro fertilization, ICSI).

Contraindications to ovulation stimulation

Ovulation stimulation is not prescribed to women who are over 35 years old, who have unsuccessful experience of previous ovulation stimulation (more than six times), as well as patients with structural disorders in the body that prevent conception and the normal course of pregnancy (with obstruction of the fallopian tubes, oncological diseases, acute inflammatory processes, uterine pathologies, etc.).

Reasons for the lack of ovulation

Sometimes the hypothalamic-pituitary system of the body fails, as a result of which a woman has a violation of the menstrual cycle, up to the complete cessation of menstruation.

The reasons for this phenomenon may be:

  • genetic: the presence of certain defects in the sex chromosomes that interfere with the normal hormonal background;
  • pathological: a tumor or inflammatory process prevents the pituitary gland or hypothalamus from producing a sufficient amount of necessary hormones;
  • indirect: the normal course of ovulation is disrupted by dysfunction of the adrenal cortex and thyroid gland, closely related to the pituitary gland and hypothalamus.

Drugs for ovulation stimulation

Currently , ovulation stimulation is carried out with the following medications:

  • menstrual (cyclic) gonadotropin. This hormone is produced by the pituitary gland and is responsible for the various phases of the menstrual cycle. Unlike chorionic gonadotropin, which is produced exclusively during pregnancy, ovulation is stimulated by hormones that regulate a woman’s reproductive cycle in her normal state;
  • artificially created (recombinant) FSH, most often Gonal;
  • Clomiphene, with the help of which the production of gonadotropins is stimulated, due to which ovulation occurs. By binding specifically to the receptors of the hypothalamus and pituitary gland, Clomiphene increases their activity;
  • traditional medicine products. Due to the content of analogues of human body hormones in some medicinal plants, preparations based on them contribute to achieving a stable positive effect in the treatment of infertility.

The dose of a particular drug is determined depending on the initial hormonal background. Each woman is selected an individual schedule of reception (ovulation stimulation protocol).

Ovulation stimulation begins on the 3rd-5th day of the menstrual cycle. To control the maturation of the follicles, ultrasound examination is performed daily, as well as basal temperature monitoring.

In addition, it is periodically necessary to take tests to determine the level of estradiol (a hormone produced by the ovaries responsible for the development of the placenta) and cervical number (studies of mucous secretions from the cervical canal: before menstruation, they acquire a more watery consistency).

In case of ineffectiveness of hormonal treatment, the dose of the drug may be increased.

An adequate reaction can be considered in the case of an increase in the follicle by 2 mm per day. If the follicle grows more rapidly, the dose of hormonal drugs must be adjusted, or stop taking them.

Effects of stimulation

The most common negative consequence of ovulation stimulation is ovarian hyperstimulation syndrome (OHSS), which is accompanied by the formation of cysts, stool disorders, fluid accumulation and deterioration of well-being.

ovulation stimulation

In accordance with the degree of OHSS, the disease may in some cases not require therapeutic measures, in others it may even require surgical treatment.

When conducting ovulation stimulation, a woman should control her well-being and listen to any changes in her health. If signs of malaise appear, you should immediately inform your doctor about them.

Ovulation stimulation often threatens the development of ectopic, as well as multiple pregnancies, due to the maturation of a large number of eggs.

One of the complications is the possible development of an allergic reaction to a particular drug taken.

The effect of ovulation stimulation occurs in 10-38% of cases. With the help of this method, the hormonal background is corrected and the necessary conditions are created for the onset of pregnancy.

The positive outcome of ovulation stimulation depends on strict compliance with medical prescriptions and on the positive attitude of the patient herself.

How to increase the chances of conceive a child

Sometimes it happens that it takes a while to conceive a child, but after several unsuccessful sexual acts, you should not sound the alarm and diagnose yourself with infertility.

Conceive a child. The first rule.

Everyone knows that the male germ cell is the basis of conception, so a certain energy is required from the sperm to ensure its mobility, because an energetic sperm is able to go further, and a weak one should not wait for conception. And if pregnancy does occur, then there is a high risk of DNA damage that leads to a frozen pregnancy or spontaneous abortion. That is why, two weeks before the decisive sexual intercourse, you need to start preparing a man. To do this, you need to start feeding him properly: include more meat, nuts, vitamin E in the diet. Such nutrition will help to increase sperm motility.

It is worth noting that excessive activity of partners for conception is not just useless, but also harmful. Therefore, before the decisive sexual act, a man should abstain for 2-3 days in order to accumulate energy. One couple went to the doctor because they could not conceive a child. During the conversation, it turned out that the couple wants a child so much that they have sex 2-3 times a day. After that, the doctor advised to abstain from sex for a few days. Following the doctor’s recommendation, the couple managed to conceive a child.

Rule number 2

The first intercourse is crucial for conception. All further acts in the evening or night are just for fun. The fact is that after the first sexual intercourse, the concentration of spermatozoa decreases almost twice, so subsequent ejaculations, as experts joke, are one water.

Rule 3, how to conceive a child

Immediately after ejaculation, a man should remove the penis from the vagina to help the sperm penetrate further unhindered, which significantly increases the likelihood of conception.

Rule 4

Female orgasm can prevent conception. This happens for the reason that during orgasm, the cervix rises slightly, so the sperm have to climb to this peak, which significantly reduces the chance of one of them reaching the egg.

conceive a child

Conceive a child 5

The right timing for conception plays a significant role in conception. A woman is more fertile in the middle of the cycle, when the egg matures (ovulation period). 5-6 days before ovulation are also considered favorable: the sperm can live as long as it waits for the egg and remains capable. The period within 6 days after ovulation is also considered favorable, since the female egg remains capable during this period of time.

The sixth rule

Of great importance for conception is the fact whether a woman takes clomid. Clomid stimulates ovulation and promotes conception. You definitely need to consult a doctor.

The last rule

The right choice of posture can significantly increase the chances of conceiving a child. Unfortunately, the choice of the right poses is not great — this is a classic missionary pose. But if you try to get pregnant, for example standing, then the liquid will just pour out. There is really an exception. If a woman has a bend in the uterus, then a pose from behind will do.

Abuse of Clomid, precautions.

Patients should be warned that during therapy with clomid, blurring or other visual symptoms may sometimes occur, such as spots or flashes (scintillation scotomata). These visual symptoms increase with an increase in the total dose or duration of therapy. These visual impairments are usually reversible; however, cases of prolonged visual impairment have been reported, with some occurring after discontinuation of clomid (not abuse of clomid). Visual disturbances can be irreversible, especially with an increase in the dosage or duration of therapy. Patients should be warned that these visual symptoms may render activities such as driving a car or operating equipment more dangerous than usual, especially in variable lighting conditions.

These visual symptoms appear to be caused by increased and prolonged therapy. Symptoms often appear or are accentuated when exposed to a brightly lit environment. While the measured visual acuity was generally not affected, the study patient taking 200 mg of clomid daily developed visual blurring on the 7th day of treatment, which led to a serious decrease in visual acuity by the 10th day. No other abnormality was detected, and visual acuity returned to normal on the third day after discontinuation of treatment.

Ophthalmologically detectable scotomata and changes in retinal function (electroretinographic) have also been reported. A patient treated during clinical trials developed phosphenes and scotomates during prolonged administration of clomid, which disappeared on the 32nd day after discontinuation of therapy.

abuse of clomid

Ovarian hyperstimulation syndrome

Ovarian hyperstimulation syndrome (OHSS) is reported to occur in patients receiving clomiphene citrate therapy to induce ovulation. OHSS can develop rapidly (within 24 hours to several days) and become a serious medical disorder. In some cases, OHSS occurred after cyclical use of clomiphene citrate therapy or when clomiphene citrate was used in combination with gonadotropins. Anomalies associated with nonspecific liver function have been reported that indicate hepatic dysfunction, which may be accompanied by morphological changes during liver biopsy, reported in connection with OHSS.

In order to minimize the danger associated with accidental abnormal ovarian enlargement associated with clomid therapy (we remind you, do not abuse clomid in any case), the lowest dose corresponding to the expected clinical results should be used. Maximum ovarian enlargement, physiological or abnormal, may not occur until several days after discontinuation of the recommended dose. Some patients with polycystic ovary syndrome who are unusually sensitive to gonadotropin may have an exaggerated response to normal doses when there is no abuse of clomid. Therefore, patients with polycystic ovary syndrome should start with the lowest recommended dose and the shortest duration of treatment for the first course of therapy.

Abuse of clomid, precautions

Careful attention should be paid to the selection of candidates for therapy. Pelvic examination is necessary before treatment with clomid and before each subsequent course.

Drugs for ovulation stimulation

Ovulation stimulation drugs that help to get pregnant are divided into three main types: follicle-stimulating hormone (FSH) and luteinizing hormone (LH) preparations, HCG preparations and progesterone preparations.

To get pregnant, you need to fulfill three basic conditions:

  1. the woman has ovulated;
  2. the sperm fertilized the egg;
  3. the embryo is securely fixed in the uterus.

Accordingly:

  1. drugs that enhance the production of FSH and LH, which help to get pregnant, stimulate ovulation — the growth of follicles on the ovaries;
  2. HCG helps the largest follicle to stay large enough and release an egg, which the sperm should fertilize;
  3. progesterone prepares the inner layer of the uterus to secure the embryo and helps to carry the fetus.

A little theory: the mechanism of ovulation

Ovulation is the release of a mature egg from the ovary. Then the egg is sent through the fallopian tubes into the uterine cavity. This happens, as a rule, in the middle of the cycle, that is, on the 14th-15th day after the onset of menstrual bleeding. Women with a regular cycle, most likely, do not ask the question “Will I be able to get pregnant?”. With a regular cycle, ovulation usually takes place regularly.

If you come to the doctor with the question “Why can’t I get pregnant” or the complaint “I can’t get pregnant for a year“, then most likely you do not ovulate. Women cannot get pregnant without ovulation.

If you are interested in the question “Why can’t I get pregnant?“, you can do an ovulation test. You can buy it at the pharmacy. Consult a doctor if there is no ovulation for several consecutive cycles.

Drugs for ovulation stimulation 2022

Ovulation may not occur for various reasons: due to hormonal failures, inflammation of the pelvic organs, and so on. If you have not been able to get pregnant for a year because ovulation does not occur, the doctor may prescribe injections and pills that help to get pregnant — stimulating it.

Drugs for ovulation stimulation: Who is shown?

If the question “Why can’t I get pregnant?” is relevant to you, then you need to undergo a checkup. It’s good if your spouse does the same — it would help to establish the cause of infertility.

Ovulation stimulation should be recommended by a doctor after a series of examinations that will give accurate data on the cause of problems with self-conception. The doctor prescribes drugs to stimulate ovulation in cases where:

  • The patient had a rare maturation of the egg and its exit from the ovaries;
  • The couple has been trying to get pregnant for more than a year to no avail;
  • Spouses older than 35-40 years do not get pregnant for 6 months.

At the same time, ovulation stimulation is prohibited in the following cases:

  • Partner infertility;
  • The presence of inflammation of the appendages, with adnexitis;
  • With pathologies of the uterus;
  • In case of poor patency of the fallopian tubes.

FSH and LH preparations. The goal is ovulation

Under the action of FSH, follicles begin to grow on the ovary — “sacs” on the surface of the ovary, in which one egg cell matures. To stimulate the growth of follicles, such drugs are most often prescribed to help get pregnant:

  • Clomid;
  • Fertomid;
  • Drugs that contain Clomiphene;

Drugs that help to get pregnant are selected individually, depending on the results of tests and ultrasound examination. In this article we describe the most famous, but not all existing drugs.

Clomiphene: mechanism of action and possible results

Clomiphene: mechanism of action

Clomiphene belongs to the group of nonsteroidal antiestrogenic drugs that stimulate ovulation. The mechanism of action of this drug is based on the activation of the synthesis of gonadotropins in the pituitary gland: FSH (follicle-stimulating), LH (luteinizing) and prolactin.

The effect of clomiphene directly depends on its dosage: the larger it is, the more gonadotropin production is suppressed, and vice versa, small doses of the drug enhance the formation of tropic hormones and promote ovulation. In addition, it is worth noting that the mechanism of action of clomiphene is affected by the concentration of estrogens in the blood: with small estrogen levels, it causes moderate estrogenic effect, and with elevated values leads to an antiestrogenic effect. At the same time, it does not affect the gestagenic and androgenic activity in any way.

Nowadays, the drug is widely used in gynecology as part of infertility therapy, because after its absorption, the processes of follicle maturation are activated and accelerated. Clomiphene is available in the form of flat tablets of grayish-white color. Its active ingredient is clomiphene citrate (Klostylbegit), in an amount of 50 mg per tablet. It is absorbed very quickly in the digestive tract after ingestion. The processes of disintegration of the drug occur in the liver, and the metabolites are completely excreted together with bile within 10-14 days.

Klostylbegit is often prescribed for IVF (in vitro fertilization) to stimulate the formation of eggs. There are cases when specialists do not wait for the rupture of the follicle, but immediately punctuate mature female germ cells for the next stage of IVF.

Indications and contraindications

The main purpose of taking klostilbegit (Clomiphene) is to stimulate ovulation, which is carried out in the following situations:

  • Anovulatory cycles;
  • Amenorrhea of various genesis or oligomenorrhea;
  • Polycystic Ovary syndrome (PCOS);
  • Pituitary tumors that cause galactorrhea;
  • Prolonged postpartum amenorrhea and galactorrhea caused by various pathological processes, for example, Chiari-Frommel syndrome;
  • Androgen deficiency.

Klostylbegit is prescribed not only for women, but also for men, since this drug has a positive effect on the quality of sperm, especially with oligospermia (a decrease in the number of sperm in the ejaculate).

Clomiphene and ovulation stimulation

But this drug can cause adverse reactions from other organs and systems, so it is contraindicated in renal and hepatic insufficiency, neoplasms of the reproductive system and pituitary gland, ovarian cysts, renal and hepatic insufficiency. It should not be used with changes in the functionality of the adrenal glands and thyroid gland, hypofunction of the pituitary gland, uterine bleeding of unclear etiology, visual and metabolic disorders. It is also not recommended to use klostylbegit during pregnancy and lactation, with hypersensitivity to the components of the drug.