Month: April 2022

Abuse of Clomid, precautions.

Patients should be warned that during therapy with clomid, blurring or other visual symptoms may sometimes occur, such as spots or flashes (scintillation scotomata). These visual symptoms increase with an increase in the total dose or duration of therapy. These visual impairments are usually reversible; however, cases of prolonged visual impairment have been reported, with some occurring after discontinuation of clomid (not abuse of clomid). Visual disturbances can be irreversible, especially with an increase in the dosage or duration of therapy. Patients should be warned that these visual symptoms may render activities such as driving a car or operating equipment more dangerous than usual, especially in variable lighting conditions.

These visual symptoms appear to be caused by increased and prolonged therapy. Symptoms often appear or are accentuated when exposed to a brightly lit environment. While the measured visual acuity was generally not affected, the study patient taking 200 mg of clomid daily developed visual blurring on the 7th day of treatment, which led to a serious decrease in visual acuity by the 10th day. No other abnormality was detected, and visual acuity returned to normal on the third day after discontinuation of treatment.

Ophthalmologically detectable scotomata and changes in retinal function (electroretinographic) have also been reported. A patient treated during clinical trials developed phosphenes and scotomates during prolonged administration of clomid, which disappeared on the 32nd day after discontinuation of therapy.

abuse of clomid

Ovarian hyperstimulation syndrome

Ovarian hyperstimulation syndrome (OHSS) is reported to occur in patients receiving clomiphene citrate therapy to induce ovulation. OHSS can develop rapidly (within 24 hours to several days) and become a serious medical disorder. In some cases, OHSS occurred after cyclical use of clomiphene citrate therapy or when clomiphene citrate was used in combination with gonadotropins. Anomalies associated with nonspecific liver function have been reported that indicate hepatic dysfunction, which may be accompanied by morphological changes during liver biopsy, reported in connection with OHSS.

In order to minimize the danger associated with accidental abnormal ovarian enlargement associated with clomid therapy (we remind you, do not abuse clomid in any case), the lowest dose corresponding to the expected clinical results should be used. Maximum ovarian enlargement, physiological or abnormal, may not occur until several days after discontinuation of the recommended dose. Some patients with polycystic ovary syndrome who are unusually sensitive to gonadotropin may have an exaggerated response to normal doses when there is no abuse of clomid. Therefore, patients with polycystic ovary syndrome should start with the lowest recommended dose and the shortest duration of treatment for the first course of therapy.

Abuse of clomid, precautions

Careful attention should be paid to the selection of candidates for therapy. Pelvic examination is necessary before treatment with clomid and before each subsequent course.

Drugs for ovulation stimulation

Ovulation stimulation drugs that help to get pregnant are divided into three main types: follicle-stimulating hormone (FSH) and luteinizing hormone (LH) preparations, HCG preparations and progesterone preparations.

To get pregnant, you need to fulfill three basic conditions:

  1. the woman has ovulated;
  2. the sperm fertilized the egg;
  3. the embryo is securely fixed in the uterus.

Accordingly:

  1. drugs that enhance the production of FSH and LH, which help to get pregnant, stimulate ovulation — the growth of follicles on the ovaries;
  2. HCG helps the largest follicle to stay large enough and release an egg, which the sperm should fertilize;
  3. progesterone prepares the inner layer of the uterus to secure the embryo and helps to carry the fetus.

A little theory: the mechanism of ovulation

Ovulation is the release of a mature egg from the ovary. Then the egg is sent through the fallopian tubes into the uterine cavity. This happens, as a rule, in the middle of the cycle, that is, on the 14th-15th day after the onset of menstrual bleeding. Women with a regular cycle, most likely, do not ask the question “Will I be able to get pregnant?”. With a regular cycle, ovulation usually takes place regularly.

If you come to the doctor with the question “Why can’t I get pregnant” or the complaint “I can’t get pregnant for a year“, then most likely you do not ovulate. Women cannot get pregnant without ovulation.

If you are interested in the question “Why can’t I get pregnant?“, you can do an ovulation test. You can buy it at the pharmacy. Consult a doctor if there is no ovulation for several consecutive cycles.

Drugs for ovulation stimulation 2022

Ovulation may not occur for various reasons: due to hormonal failures, inflammation of the pelvic organs, and so on. If you have not been able to get pregnant for a year because ovulation does not occur, the doctor may prescribe injections and pills that help to get pregnant — stimulating it.

Drugs for ovulation stimulation: Who is shown?

If the question “Why can’t I get pregnant?” is relevant to you, then you need to undergo a checkup. It’s good if your spouse does the same — it would help to establish the cause of infertility.

Ovulation stimulation should be recommended by a doctor after a series of examinations that will give accurate data on the cause of problems with self-conception. The doctor prescribes drugs to stimulate ovulation in cases where:

  • The patient had a rare maturation of the egg and its exit from the ovaries;
  • The couple has been trying to get pregnant for more than a year to no avail;
  • Spouses older than 35-40 years do not get pregnant for 6 months.

At the same time, ovulation stimulation is prohibited in the following cases:

  • Partner infertility;
  • The presence of inflammation of the appendages, with adnexitis;
  • With pathologies of the uterus;
  • In case of poor patency of the fallopian tubes.

FSH and LH preparations. The goal is ovulation

Under the action of FSH, follicles begin to grow on the ovary — “sacs” on the surface of the ovary, in which one egg cell matures. To stimulate the growth of follicles, such drugs are most often prescribed to help get pregnant:

  • Clomid;
  • Fertomid;
  • Drugs that contain Clomiphene;

Drugs that help to get pregnant are selected individually, depending on the results of tests and ultrasound examination. In this article we describe the most famous, but not all existing drugs.