How to buy Clomid online safely: Tips for dummies

We decided to write this brief instruction on how to buy Clomid online safely since now it has more sense than ever. Nowadays, many prefer purchasing almost everything on the web. Online shopping saves both time and (most often) money. When you search for medicines, you additionally avoid fixing an appointment with a doctor, passing unnecessary medical exams, and so on. Moreover, today, many people keep away from hospitals and regular drugstores due to the pandemic.

Women who need Clomid to get pregnant and men who have to take this particular medication can follow our advice to buy it online safely. However, mind that for a successful treatment you must carefully read the instructions and strictly follow the recommendations. So, in addition to buying your medicine on the web in the safest way, think about your own health.

A quick guide to using Clomid for dummies

But first, let’s recall who needs Clomid, and how to use it correctly. First of all, doctors prescribe this irreplaceable means for stimulating ovulation to women with irregular menstrual cycle and other similar problems. As a rule, after literally three courses of treatment, a long-awaited pregnancy occurs. This happens even to those who have tried unsuccessfully to conceive a child for years. Therefore, we understand why women are so interested in buying Clomid online safely.

Tips on buying medicines online in a safe way

online safely

Now let’s move on directly to how you can buy Clomid online safely, without risking your health, finances and personal data. By the way, these tips concern online shopping in general.

What to pay attention to if you want to buy Clomid online safely:

  • Compare prices for the same items from different sellers. For example, find several websites that offer Clomid in the most popular 50mg dosage. Then, choose the best deals. At the same time, try to avoid suspiciously too low prices – this may indicate insufficient quality or even fake pills.
  • Then, read reviews left by other patients. Good online shops always have a feedback section, and grateful customers will certainly leave some comments. Moreover, from these reviews, you can learn a lot of useful information about the use of Clomid or other medicines you need. In particular, pay attention to dosages and side effects other people mention.
  • Also, pay attention to the available shipping and payment methods. The wider the possibilities, the better for you. In particular, some sellers provide an opportunity to pay for goods even with Bitcoin. As a rule, good online pharmacies also allow you to choose one of the delivery methods – a cheaper (but also slower) regular airmail or a more expensive (but faster) courier service.
  • Shop only on the sites which provide safety of your personal and financial data. If you want to buy Clomid online securely, make sure your payment details are processed through a secure connection – for example, SSL. As a rule, a corresponding message appears on the site at the time you should pay for your order. In addition, the site’s security is indicated by https: // in the address.
  • Finally, before making a purchase, look for discounts or other pleasant bonuses offered. For example, it could be the option of free shipping when spending a certain amount. Or, you may count on an additional discount as a regular customer. Also, some websites allow you to purchase Clomid online safely, guaranteeing complete anonymity.

We hope our short guide to buying Clomid safely online will help you!

Ovulation after 40 years: symptoms of ovulation in women 40 years old

With age, a woman’s reproductive function declines. This process is accompanied by an increase in the number of anovulatory cycles. Despite this, a woman is still able to get pregnant, as menopause occurs gradually.

Features of ovulation after 40 years:

Age is one of the main factors affecting a woman’s ability to conceive. The supply of oocytes in the body is limited. It lays at the stage of embryonic development. Some of the eggs die in adolescence. The remaining oocytes are consumed with each menstrual cycle. Therefore, by the age of 40, there are very few eggs left. The work of the reproductive organs during this period changes dramatically. This affects the overall well-being of a woman.

Ovulation after 40 years is much less common than at a younger age. This is due to a physiological decrease in the level of estrogens in the body. The hormone is responsible for the maturation of eggs and increasing the thickness of the endometrium. In addition, it is responsible for preserving youth. When the production of estrogens is disrupted, there is a change in the duration of the menstrual cycle. In some women, it completely disappears. Lack of estrogen in the body is accompanied by the following signs:

  • Deterioration of skin elasticity;
  • Frequent mood swings;
  • Depression libido;
  • Changes in the nature of selections.

Life expectancy of an egg after ovulation in a woman’s body after 40 years

Doctors say that ovulation after 40 years rarely leads to a successful pregnancy

This is due to a reduction in the life span of the egg after it leaves the follicular walls. Until the age of 40, it lives an average of 24-48 hours. This figure decreases markedly with age. Pregnancy in this case becomes possible if the man’s spermatozoa are active enough. In other cases, you may need the help of specialists.

Symptoms of ovulation in women 40 years old:

In General, ovulation after 40 years has no special distinctive features. It runs the same way as before. Some women do not notice any characteristic symptoms of the fertile period. It may be accompanied by the following symptoms:

  • Increased sexual desire;
  • Heaviness in one of the ovaries;
  • Flatulence;
  • Increasing the volume of vaginal secretions and changing their consistency;
  • The increased sensitivity of the mammary glands;
  • Increased sense of smell and taste.

Painful sensations in the area of appendages begin 2-3 days before the rupture of the follicle.

Every day they become more intense. The discharge becomes slimy and transparent. Just before ovulation, the cervical mucus is thinned. Libido increases markedly. Mood swings may also occur.

When fertility increases, the position of the uterus changes. It rises high in the vagina and becomes softer. The throat opens slightly. This is necessary for unhindered penetration of seminal fluid into the genital tract. At the same time, the basal temperature index decreases. It can be detected early in the morning, after waking up. Measurements are carried out with a mercury thermometer in the rectal opening.

Ovulation after 40 years

Ovulation after 40 years and not only is easy to determine by ultrasound. It is recommended to perform monitoring starting from the 12th day of the cycle. The following signs indicate an early rupture of the follicle with a Mature egg:

  • Presence of a dominant follicle larger than 18 mm in one of the ovaries;
  • The thickness of the endometrium exceeds 10 mm;
  • The throat of the cervix opens.

An ovulation test helps you get more information. It responds to an increase in the hormone LH in the body. But the result should be interpreted in conjunction with other signs of ovulation. LH can increase not only during the fertile period, but also in the presence of gynecological diseases.

After the expected ovulation, the woman should visit the ultrasound again. The fact that the follicle has successfully ruptured is indicated by its disappearance and the presence of fluid behind the uterine cavity. In place of the follicle, a yellow body appears, which is characterized by uneven outlines. The absence of characteristic signs of the ovulatory period indicates luteinization of the follicle. This problem requires adjustment of the hormonal background with medication.

How often do women ovulate after 40?

The frequency of ovulation in women 40 years old depends on a combination of factors. These include hereditary predisposition, hormonal background, lifestyle of a woman and concomitant diseases. Some women at this age do not experience significant changes. In others, the frequency of ovulatory cycles may be only 3-4 times a year. To determine the degree of readiness of the egg for fertilization, you should visit an ultrasound examination.

Reasons for the periodic absence of ovulation after 40 years

Ovulation after 40 years may be absent for a long time. This is due to changes in the hormonal background. But in some cases, anovulation is provoked by gynecological diseases or an incorrect lifestyle. Ovarian dysfunction can be caused by excessive alcohol consumption and Smoking. Other possible reasons for the lack of ovulation include:

  • Inflammatory process in the small pelvis;
  • Sexual infection;
  • Polycystic ovary syndrome

If anovulation is triggered by external factors, there is a possibility of artificial stimulation of ovarian function. For this purpose, hormone-based medications are taken.

In any case, you can use clomid to stimulate ovulation.you can find the price list for this drug on our website.

Complete absence of ovulation after 40 years indicates early menopause. Its cause is a genetic disposition. In this case, the probability of conception is reduced. Menopause is characterized by the complete disappearance of menstruation. With the help of specialized drugs, a woman can smooth out the manifestation of the menopausal period. They are prescribed by the attending physician, based on the state of health of the woman.

Legal anabolics and pharmacology in bodybuilding

For natural bodybuilders and those who have decided to stop using steroids, I would like to offer a methodological development for taking permitted pharmacological drugs. This technique is designed to build muscle mass, restore performance and increase endurance of athletes in bodybuilding and other power sports. Of course, compared with modern “chemistry” (for example, the use of clomid), the results will not be the same, but there is no risk to health. And in combination with sufficient nutrition and sports supplements, your progress will be more significant in any case than if you trained without these drugs. From my own practice, I can add that for 3-4 months of training and following this method, the athletes I trained managed to gain 10-15 kg of muscle mass! And it was not water, “proxymachine” muscles, which immediately subsided upon completion of the course “chemistry”. The result was fixed steadily and for a long time. And, what is most interesting, such results were achieved not only without steroids, but also without modern sports nutrition products, and with sportpit products, we can expect more significant progress.

For those athletes who have no particular problems with gaining muscle mass, as well as for pronounced endomorphs, i.e. those who are prone to excess weight and who have a problem with excess fat rather than with muscles, this Chapter will also provide recommendations on how to solve this problem – and get rid of fat, and give the muscles a better visual appearance.

What progress can we expect?

Almost all of the described drugs are of domestic origin, which implies their availability and relatively reasonable cost. These drugs are quite highly rated for quality and effectiveness in the medical industry and in sports medicine.

Legal anabolics and pharmacology in bodybuilding

It is known that combinations of pharmacological drugs either enhance the effect of each other, or suppress. Combinations of drugs are quite effective in their effect on muscle growth. I am sure that after passing several courses on these drugs, many who were on “chemistry” will refuse it. Why ruin your health and lose muscle after “chemistry” courses, when there is an alternative to “throw” 5 kg or more of clean muscle every-even if not 3-4 months, as with my wards , but even a year? In addition, you will not have “chemical”, water muscles, for which you will need to shake, as if they did not come off, but a healthy working mass, which will always be with you. Of course, on steroid courses you will gain much more weight, but the risk of side effects is very high.

To adapt and rest the body from very powerful force stress and rapid growth of muscle mass, it is advisable to conduct no more than 3 courses per mass per year (2-3 months each). It is also advisable to be under the supervision of a doctor (preferably a sports doctor) and a competent personal trainer during these courses.

For those who are engaged in the type of addition is an endomorph or who are quite satisfied with the overall muscle mass, but are not satisfied with the quality of the muscles, waist width and their own press (or rather its absence), you will need to use the recommendations for taking these drugs from relief periods.

What dictates the selection of pharmacological drugs in sports, I just want to make a reservation That these drug regimens are intended for natural bodybuilders who train fundamentally without steroids or for those who are done with them. The “chemists” have completely different drugs, their reception schemes and courses.

The selection of an individual complex of pharmacological agents (for example, clomid) for each athlete as a whole should be determined by:

  • Data from current and dynamic medical and biochemical observations.
  • The presence of the identified “limiting” link (Central nervous system, cardiovascular system, etc.)
  • Features of adaptation, resistance and hyperactivity to the same drugs.
  • The need to prevent and treat chronic diseases in this athlete.
  • Psychological status and behavioral responses in the competitive period.

Ovulation – what is it in simple words

Ovulation is a cyclical physiological process in which a Mature egg is released from the ovary. During this period, the highest probability of fertilization of the egg, so determining the fact of ovulation is very important for women who want to get pregnant.

What happens when you ovulate

During ovulation, the physiological process of leaving a Mature egg from the ovary with its subsequent entry into the fallopian tube, where fertilization can occur. The process is cyclical in nature, the release of the egg occurs every month on about 14 days from the beginning of the menstrual cycle (a possible slight deviation in the timing of ovulation is considered normal).

Directly the exit of the egg from the ovary takes a period of time about an hour. Then it moves into the uterine tube (movement occurs due to the movement of the villi of the fallopian tube mucosa). In the fallopian tube funnel, an egg can be fertilized by a sperm within 24 hours. If this does not happen, then it dies.

The entire period of time when there is the highest probability of ovulation is called the ovulatory period. It is the most favorable for the conception of a child. The reliable duration of the ovulatory period remains unexplored, usually a favorable period for getting pregnant is 1 day before and after ovulation.

How ovulation is regulated

Ovulation is a complex physiological process that is regulated by certain hormones. The pituitary gland produces follicle-stimulating hormone, which increases the rate of egg maturation and follicle formation (the vesicle before ovulation can reach 2 cm in diameter).

During the maturation of the follicle, estrogens are released. They affect the hypothalamus, pituitary (structures of the Central nervous system), stimulating the production of luteinizing hormone, responsible for maturing the egg. The increase in the concentration of the hormone in the blood begins 36-48 hours before ovulation and has a peak character.

After the exit of the germ cell, a yellow body is formed in place of the damaged vesicle (the postovulatory phase of the menstrual cycle). Knowledge of the regulation of the ovulation process is necessary to find out the causes and mechanism of various changes in which female infertility can develop.

Why to determine ovulation

The fertilization process occurs only when a Mature egg is released and moved into the fallopian tube. After unprotected sexual intercourse, spermatozoa usually move to the fallopian tube within 24 hours (the lifetime of a Mature egg that has left the ovary) and fertilize the egg.

ovulation

The ovulatory period is the most favorable for fertilization of an egg and conception of a child, so at the stage of pregnancy planning, a woman finds out the time of ovulation. If ovulation was detected when using the test system, it is recommended to carry out conception within a day after the test.

How to determine ovulation

The entire ovulatory period and the process of direct release of the egg from the ovary does not manifest itself clinically. The General condition and well-being of the woman does not change. Therefore, in order to reliably determine ovulation, you can use several common methods:

Calculation of ovulation.

The calculation of the possible day of ovulation during a regular menstrual cycle. The first day of the cycle is considered the beginning of menstruation. With a known and equal number of all days (on average, the cycle lasts about 28 days) of the menstrual cycle, its middle (day 14) will coincide with the beginning of ovulation. For the convenience of counting, you can use a special calendar of the menstrual cycle.

Determination of ovulation by body temperature.

Measurement of a woman’s body temperature, which is better performed in the rectum (it is possible to get more reliable measurement results). During ovulation, due to the peak production of luteinizing hormone, there is a small (on average, half a degree) rise in temperature. For convenience, it is recommended to measure throughout the entire menstrual cycle and make a schedule.

The ovulation test.

Using a special ovulation test is a modern technique that is based on determining the appearance of luteinizing hormone in a woman’s body fluids (urine, saliva). The diagnostic system can be represented by test strips. They are dipped in a vessel with collected urine, and then the result is recorded. The presence of 2 strips (experimental and control lines) indicates the presence of luteinizing hormone in the blood and determines ovulation.

Thanks to the availability of modern test systems for ovulation, its determination has become much easier.

What determines the time of ovulation

In the normal functional state of the endocrine and reproductive systems, ovulation occurs approximately on the same day of the menstrual cycle. Changes in the timing of the release of a Mature egg from their ovary are recorded in 20% of cases and may be the result of various provoking factors:

  • Endocrine pathology that affects the pituitary, adrenal, or sex glands.
  • Infections of the reproductive system, which also include sexually transmitted diseases (mycoplasmosis, ureaplasmosis, trichomoniasis, chlamydia).
  • Chronic pathological conditions of the internal genitals, which include polycystic ovaries, endometriosis.
  • Metabolic disorders (metabolism) with the development of obesity.
  • Suffered excessive physical, mental, emotional stress.
  • Genetic predisposition, inherited (syndrome of early ovarian depletion, which develops before the age of 40 years).
  • Age-related physiological decline in the functional activity of the reproductive system.

Diagnosis of the causes of ovulation disorders is necessary for effective treatment of various changes in the functional state of the reproductive system that lead to female infertility.

Why is there no ovulation?

So, now you know what ovulation is, in simple words, it is the release of an egg from the ovary, which can be fertilized by a sperm. Due to ovulation, pregnancy occurs. If this process is disrupted, the woman can not conceive a child. Try to buy clomid online and use it, in most cases it helps to conceive a child.

Some women do not ovulate. Why is this happening? Consider all possible reasons why eggs may not Mature in the ovaries. They can be physiological and pathological.

Physiological cause

  • early age, before puberty – girls may not ovulate even up to 15-16 years, although these processes usually begin after 13-14 years;
  • late age – over the years, ovulation occurs less and less, after 50 years, the egg in many women no longer Matures at all;
  • pregnancy – during the period of carrying a child, it is impossible to conceive another one;
  • lactation – during this process, the hormone prolactin is produced, which blocks the production of FSH (this hormone stimulates the maturation of follicles in the ovaries, so if it is not produced in the pituitary gland, ovulation does not occur).

Often there is no female ovulation, because there are some disorders in the body. In the vast majority of cases, the endocrine factor is to blame. That is, ovulation does not occur because certain hormones are too much or too little. As soon as their number becomes normal, ovulatory processes will again occur in the ovaries every month.

Pathological causes

  • damage to the ovaries as a result of trauma, surgery, radiation, tumors, etc.;
  • surgical removal of the ovaries;
  • their underdevelopment (congenital anomalies);
  • premature ovarian depletion syndrome (early menopause).

Note that if ovulation is absent, it does not mean that it will never happen. In women with endocrine disorders, it can occur, it just happens less often. It is more difficult to catch the moment for fertilizing sexual intercourse to conceive a child. In healthy women, eggs Mature 10-12 times a year. In endocrine diseases, this can occur only 2-3 times a year. The majority of cycles remain anovulatory. In addition, the duration of a single menstrual cycle can sometimes reach several months due to an increase in the duration of the follicular phase. That is, the period during which the ovary grows a follicle with an egg.

Clomid in bodybuilding

Taking steroids helps you gain muscle mass quickly. However, you have to pay for everything: after the end of the course, athletes have to make a huge effort to restore their body. A particularly acute problem is a decrease in the intensity of testosterone production. In this case, so-called antiestrogens come to the rescue, the most effective of which is clomid.

Why do I need to take antiestrogens?

Antiestrogens are widely used by athletes who use androgen-anabolic steroids to increase the effectiveness of training. It is difficult to overestimate the benefits of antiestrogens, because after a course of steroids, the endocrine glands reduce the production of testosterone. This happens for a simple reason: if the hormone enters the body from the outside, the need for its production disappears. As a result, the pituitary-hypothalamus-ovarian arc becomes less and less active. And the longer an athlete takes steroids, the less testosterone is produced. It is important that the rate of decrease in the activity of your own glands depends on the intake of prolactin, estradiol and progesterone. If the level of one of these hormones exceeds a certain value, the activity of the endocrine glands will be suppressed even more. Therefore, it is important to monitor the level of hormones, pass tests on time and always have at your disposal extradiol and prolactin inhibitors.

Clomid in bodybuilding

The less active the pituitary-hypothalamus-ovary arc becomes, the more effort will have to be spent to “Wake it up”. Naturally, you need to get your testosterone levels back to normal as quickly as possible: this affects not only your appearance, but also the effectiveness of training. In order for testosterone levels to return to normal as soon as possible, it is recommended to take antiestrogens: clomiphene citrate, tamoxifen citrate and torimifene citrate. Unfortunately, recovery with tamoxifen is best abandoned: it is considered the dirtiest and you can expect quite unpredictable side effects from taking it. The most effective drug that many athletes recommend is clomiphene citrate, otherwise called clomid. Of course, it is quite expensive, but the quality and result fully justify the high cost.

How does clomid work?

Many athletes after a course of taking steroids try to restore the level of testosterone, using dietary supplements, herbal infusions and other questionable means. This should not be done: after the course, the body is in a hormonal pit, when the level of follicle-stimulating and luteinizing hormones is almost zero. And it is from these hormones depends on the intensity of testosterone secretion.

Clomid affects the production of FSH and LH. In addition, it connects to estrogen receptors. Therefore, even if a high level of estrogen is detected in the athlete’s blood, you should not be afraid: the hormone will be in an inactive form.

In the first days of taking clomid, LH and FSH levels quickly peak, while testosterone levels increase. In just a couple of weeks, the testosterone level returns to the state that was observed before the course of steroids. However, the duration of taking the drug depends on the individual characteristics of the athlete’s body: someone needs two weeks, someone needs several months.

How to take clomid on PCT after the course

The dosage of clomid depends on the course of steroids taken. The more drugs were taken and the higher their dosages, the longer it will take to bring the body back to normal. In General, the reception scheme looks like this:

  • after a very hard course – 3×150, 12×100, 15×50, 15×25;
  • after a hard course – 15×100, 15×50, 15×25;
  • after the middle of the course – 30×50, 15×25;
  • after a light course – 15×50, 15×25, 15×25 (once every 2 days)
  • after a very easy course – 15×50, 15×25.

The first digit represents the number of days during which the drug should be taken. The second digit is the recommended dosage of the drug. For example, 15×100/15×50 will indicate that clomid should be taken for 15 days at 100 mg, and then for another 15 days at 50 mg.

Reviews of the drug

There are almost no negative reviews about the drug on the Internet. This does not seem surprising: clomid has no side effects, at least if taken in accordance with the instructions and recommendations of specialists. Clomid makes it possible to quickly restore testosterone levels after a course of steroids, and also contributes to minimal loss of muscle mass.

Ovulation stimulation in women after 40 years

Some couples decide to have a second child many years after the birth of their first child. Often, doctors resort to ovulation stimulation after 40 years, because the supply of eggs can be used up. As a result, after stimulation in the form of hormonal drugs, ovulation returns, so there are chances of conception. This method in medicine is effective, thanks to it, many women become mothers after 40-45 years.

What is the stimulation of ovulation

The absence of an egg from the follicle, according to research, is considered a common pathology in gynecological practice. Most often, it is associated with hormonal imbalance, incorrect body weight and other diseases of the internal genitals.

To Wake up the sleeping ovaries, you need to trigger the ovulatory process. This is often done with hormonal medications. Their action in the body contributes to the development of the follicular capsule and the release of EGGS capable of fertilization. In addition, the menstrual cycle is restored.

Ovulation stimulation in women after 40 years

Often, medications are used that have different effects on the woman’s body. It is worth remembering that the appropriate method is suitable only for those ladies whose appendages are completely healthy. We are talking about cases when the follicles do not break, and they need help.

Features of stimulation after 40 years

For women of this age, a personal treatment regimen is developed if they cannot get pregnant in the usual way. Some patients refuse this method, because they are afraid of the birth of twins, as well as the influence of other side effects. However, a number of ladies still agree to the doctor’s proposal, since the eggs are not able to perform their main function.

To restore ovulation, you have to resort to IVF. This method is also suggested because the reproductive age has already ended. In this regard, it is necessary to use the help of donors and the spouse’s sperm, if it is of high quality.

For all these processes to be carried out successfully, women need to find a competent specialist in this matter. After a comprehensive examination, he will select the right hormonal agents that will not cause damage to the body.

It is not superfluous to use folk remedies as an auxiliary therapy to the standard stimulation Protocol. Herbs will help restore fertility, the main thing is to consult your doctor before using them.

Preparation and contraindications

Before ovulation is stimulated, each expectant mother must undergo a detailed examination. Evaluating the results of tests, the doctor will exclude all pathologies that may negatively affect the success of this method. In particular, it is necessary to:

  • pass tests to detect infections in the genital tract;
  • smear from the vagina;
  • donate blood for various hormones;
  • conduct a cytological examination;
  • ultrasound of the mammary glands;
  • ECG;
  • find out whether the fallopian tubes are passable;
  • get the results of the analysis for TORCH infections;
  • if necessary, do a laparoscopy.

A spermogram will be required from the partner. If the male factor of infertility is absent, then you can start treatment for a woman.

However, the Protocol does not apply to all patients. It can not be performed for the following pathologies:

  • genetic abnormalities of a chromosomal nature;
  • obstruction of both tubes;
  • hereditary diseases;
  • somatic abnormalities;
  • dysfunction of the kidneys, heart or liver.
  • inflammatory processes of the reproductive system; polycystic ovaries.

Performing stimulation after 40 years

The main component of the prescribed drugs can have different effects on the body as a whole. Most often, medications begin to be taken from the third day of the menstrual cycle. Often, intramuscular injections are prescribed to enhance the action. The action can be either gonadotropic or antiestrogenic. All this is determined by the primary clinical picture. Diagnosis of follicle formation is performed by ultrasound.

After analysis of the dominant follicular capsule, a HCG injection is administered. If all the activities were carried out for IVF, then the YC fence can be performed every other day. In the case of the natural way, couples need to have unprotected sex.

As a rule, no more than two cycles of hormone use are sufficient. If the desired effect on the reproductive system is not found, doctors change the treatment regimen. Sometimes there are cases when conception occurs from the first time.

Conclusions

Ovulation stimulation after 40 years is possible only if a woman is in good health. This conclusion is based on the survey conducted. Stimulation of ovulation is performed with the help of injections and pills that normalize hormonal balance. After 40 years, you should seriously think about whether to give birth, because there are certain health risks.

Why is it not always possible to get pregnant during ovulation?

When a couple starts planning to conceive a baby, the first few unsuccessful attempts can cause a lot of questions — why pregnancy does not occur, because partners try to conduct sexual acts during this, the most favorable fertile female period. In fact, this is a normal situation, the reasons for which may be quite natural. But also pathological prerequisites are not excluded.

General information

Ovulation is a short period of the female menstrual cycle when a Mature egg comes out of the dominant follicle into the fallopian tube. A set of germ cells in an immature state in girls is available even when the baby is in the womb. Then, during life, part of the first — order oocytes die, and part is spent on ensuring the cyclical work of the female body. Each month, one (rarely more) follicles ripen, which break in the middle of the cycle under the influence of hormones, releasing an oocyte ready for fertilization by a sperm.

Ovulation lasts about an hour, and then for another day the egg retains the ability to be fertilized.

If during these days the meeting with the male sex cell does not occur, the oocyte dies, descends into the uterus and comes out with menstrual bleeding along with endometrial particles that have grown under the influence of progesterone in the second phase of the female cycle in anticipation of a fertilized egg.

Female fertility (the ability to reproduce) is largely due to the ovulatory process, and the probability of conceiving a child on the days of ovulation is maximum. But the maximum is not 100%. According to who, female fertility during ovulation depends on age, its highest value is no more than 33% in women under 25 years of age, no more than 25% in women under 30 years of age. Reproductologists say that these figures are somewhat inflated, and the real probability of conceiving a child for the first time in one cycle in healthy women and men does not exceed 11% at the age of 20-25 years. Naturally, after 35 years, the probability does not exceed 4-7%, and after 40 years — 3%.

This is due to the deterioration of the genetic material of the female germ cells, and if the partner is age-related, then his germ cells are probably not of excellent quality. These statistics are not a cause for concern. About 60% of married couples get pregnant safely within six months, and another 30% of couples see positive pregnancy test results within a year.

In about 25% of cases, even if sexual intercourse was performed exactly during the fertile window, conception does not occur, and the reasons for this have not yet been established by geneticists and doctors. In addition, in almost half of cases of family infertility, poor sperm quality plays a decisive role.

why it is not always possible to get pregnant during ovulation

Conditions for successful conception

To find the answer to the question of why a woman can not get pregnant during ovulation with the first or second baby, you need to make sure that the couple correctly approaches planning and meets all the conditions for successful conception.

A woman is ovulating

The fact is that every lady in the course of life there are “empty” anovulatory cycles. The older a woman gets, the greater the number of such cycles per year (compare — in 20 years, anovulatory cycles are usually 1-2 per year, and in 35 years — up to 5-6). Ovulation can also occur late or earlier, and this scenario can be triggered by stress, a cold, a trip, or a flight.

In order to answer the question of whether the egg is released at all, you can use home ovulation tests: when they show two stripes, it’s time to start active actions.

The accuracy of home tests is lower than laboratory tests, and you can visit a doctor to do an ovarian ultrasound on day 5-6 of the cycle immediately after your period. And closer to the middle of the cycle, you can do a blood test for luteinizing hormone. Its sharp jump indicates the approach of ovulation.

The man is healthy and capable of conception

A simple analysis — spermogram will help significantly reduce the time and nervous costs when planning a baby. If the quality of a man’s germ cells leaves much to be desired, the probability of fertilization is significantly reduced, and the risk of conceiving a child with genetic abnormalities or chromosomal errors increases.

In this case, you first need to improve the quality of sperm by taking vitamins, giving up bad habits, visiting the bath and sauna. And only after three months (this is how long spermatogenesis lasts) to start the exciting process of “catching” ovulation.

Sexual acts occur during the fertile window

Spermatozoa live longer than the egg (up to 3-4 days), they are quite capable of “waiting” for the egg to come out already in the fallopian tube, and therefore it is recommended to start having sex 3-4 days before ovulation and do it a day later up to 2-3 days after ovulation, refusing to use contraception, douching, and lubricants.

With moderate frequency of sexual contact, a man’s sperm will be of optimal quality, which will help to conceive a baby faster.

The couple is in the right psychological state

Any stress increases the production of stress hormones, which partially block the production of sex hormones. That is why it is often impossible to get pregnant, even if the sperm is of normal quality and ovulation is present. Doctors have long noticed that conception occurs most quickly in the first year of a couple’s life together, while the feelings are fresh. If you turn sexual acts into a sports attraction with the sole purpose of conceiving, the probability of successful conception decreases.

A woman who every month with trepidation waits for two stripes on the test, can not be distracted by anything else, switch, is in a state of chronic stress, and the probability of conception itself becomes several orders of magnitude lower.

why it is not always possible to get pregnant during ovulation

Possible reasons for the lack of conception

A variety of factors can affect the ability of male and female cells to merge, and not all of them have been studied in detail by doctors and scientists. But even those that are known are quite enough to understand that conception is a delicate matter.

It’s mostly about the health of the partners. A woman’s probability of conception is reduced not only by age, but also by bad habits, living in an area with unfavorable environmental factors, working at night, professional contact with radiation, paints and varnishes, and toxins. And even if there is ovulation, it is not a fact that the oocyte will be of good quality and fertilization will be successful.

The male fertility factor can be affected by the habit of wearing tight underwear and trousers, which disrupt blood circulation in the scrotum and increase its temperature. The habit of steaming in the bath, turning on car seat heating also affects the quality of sperm.

We can’t even imagine how many conceptions we’ve missed in our lives! After all, sometimes pregnancy “breaks down” at the very initial stage — the fetal egg cannot descend into the uterus, implantation does not occur, because of a genetic error, it stops developing and growing and dies. In this case, your monthly period may arrive a little late. And a woman will never know that conception did take place.

The reason for the absence of pregnancy with strict adherence to the rules of successful conception can be any gynecological pathology — obstruction of the fallopian tubes, inflammation in the uterus, ovarian dysfunction. Often, doctors also diagnose hormonal infertility, in which the level of hormones in the female body does not allow her to be pregnant (progesterone or estrogen deficiency). Often, ovulation does not occur, and if it does, the level of natural hormonal support may not be sufficient to ensure the survival of the embryo in the very first days after conception.

In men, the cause may be hidden in varicocele, prostatitis, and sexual infections, many of which occur without pronounced symptoms, and therefore can not be immediately noticed by the carrier.

We should also talk about antisperm antibodies that produce the immune system of a man or woman. The immune defense simply perceives spermatozoa as foreign objects, and throws all its forces at their speedy destruction. In this case, sperm die in the body of a man, if he has antisperm antibodies, or die before reaching the egg, if such immune cells are produced in a woman.

The immune system can react to sperm this way for some reasons. For example, a man underwent surgery on the genitals, there was an injury, a bruise of the genitals, and individual germ cells, getting not where they should be, caused an aggressive immune response. In women, this form of infertility develops due to excessive passion for anal sex with ejaculation in the rectum, as well as when swallowing sperm during oral contact. This is one of the most difficult types of infertility to treat.

What to do?

Whatever your ideas about your own fertility, it’s best to start planning a pregnancy by going to the doctor. A woman needs to be examined by a gynecologist, put her own weight in order (even losing 5% of the original body weight increases the likelihood of conception). It is also important for a man to pay attention to his diet, bad habits and make a spermogram.

A simple and quick survey will allow the couple to plan more constructively for adding to the family, to know exactly the “weak” sides of each other. Let’s just say that there are almost no insurmountable situations. Even if some abnormalities are detected, in 96% of cases, after correctly selected treatment, the problem is eliminated, and the couple can begin to successfully plan the baby.

The remaining 3% of couples will be helped by methods of assisted reproductive medicine — IVF, ICSI, egg donation, sperm donation.

A trip to a psychotherapist is inevitable in psychogenic infertility, when the cause lies in severe stress, emotions, and fears. After eliminating these feelings, the couple usually manages to conceive a baby without any problems.

Clomid (clomiphene) or nolvadex (tamoxifen), which is better?

In this article, we will try to resolve doubts about the choice between two drugs, as well as find differences: clomid or nolvadex.

Clomiphene citrate (available in pharmacies under the brand name Clomid) and tamoxifen (trade name Nolvadex) are antiestrogens belonging to the same group of triphenylethylenes. They are structurally similar and classified as selective estrogen receptor modulators with mixed agonistic and antagonistic properties. This means that in certain tissues they block the action of estrogen by binding to receptors, while in other tissues they can act like real estrogen by activating receptors. In men, both drugs act as antiestrogens in their ability to interfere with the negative feedback of estrogens to the hypothalamus and stimulate increased production of GnRH (gonadoliberin). As a result, the production of the luteinizing hormone prolactin and the follicle-stimulating hormone by the pituitary gland will be increased, which in turn can increase the production of testosterone by the testicles. Both drugs do this, but for some reason, bodybuilders continue to think that only clomid is good for stimulating testosterone.

bodybuilders: clomid or nolvadex?

Research conducted in the late 70s at the University of Ghent in Belgium clarifies the benefits of nolvadex over clomid in increasing testosterone levels. The researchers looked at the effect of nolvadex and clomid on the endocrine system of healthy men, as well as those who suffered from a small number of sperm (oligospermia). It was also found that Nolvadex, when used for 10 days at a dosage of 20 mg per day, increased serum testosterone levels by 142% from the initial level, which was comparable to the effect of 150 mg of clomid per day over the same time period (the increase in testosterone levels was slightly, but not significantly, more with clomid). We must remember that this is the effect of three 50mg clomid tablets. With approximately the same price of 50mg of clomid and 20mg of nolvadex, we already see a difference in the price / result ratio in favor of nolvadex.

Differences between clomid and nolvadex

Clomid acts on estrogen receptors in the pituitary gland and ovaries. By binding estrogen receptors in the pituitary gland, clomid breaks the negative feedback mechanism, i.e. if usually estrogens, acting on the pituitary gland, reduce the production of FSH and LH, this does not happen when taking clomid. Clomid does not directly affect the level of estrogens in the blood.

Nolvadex also does not affect the level of estrogens in the blood, because its mechanism of action is also reduced to the blockade of estrogen receptors, including in the pituitary gland. However, clomid is a more selective (selective) blocker, while nolvadex is less selective. While clomid binds to estrogen receptors primarily in the pituitary gland and testicles, nolvadex binds to them almost throughout the body. The exception is bone tissue, where clomid and tamoxifen, on the contrary, activate estrogen receptors.

Thus, clomid acts as an antagonist of estrogens and eliminates their depressing effect on the hypothalamus and pituitary gland, contributing to a faster recovery of their function. Nolvadex blocks receptors in almost all tissues, and also helps the body begin to restore its own testosterone. It is important to note that nolvadex is able to block estrogen receptors in the pituitary gland to a lesser extent than clomid.

Clomiphene and tamoxifen do not affect the metabolism of estrogenic hormones, so against the background of taking these drugs, estrogens continue to be destroyed by liver enzymes, and do not accumulate in the body.

Tamoxifen has disadvantages: it is quite toxic (sometimes it is manifested by loss of appetite and nausea, and the risk of thrombosis increases). Tamoxifen increases the number of progesterone receptors, so it can not be used if the course is based on progestin drugs (nandrolone, trenbolone). In this case, you should use clomiphene.

Clomid: common fault

  • Both drugs inhibit the production of insulin-like growth factor-1
  • Directly inhibit the function of the testicles
  • Increase sex hormone binding globulin
  • Increase the concentration of estrogens several times
  • Cause visual impairment with prolonged use
  • In some cases, when using Clomid for a month at a dosage of 25 mg per day, after 2 weeks after the end of the course, there was a decrease in total testosterone by 16-17% (while there was a decrease in estradiol by 13.5%)
  • It is important to understand that in some people, the pituitary-hypothalamus-testicular arch (GGT) may not respond to stimulation with Clomid (clomiphene) or nolvadex (tamoxifen)

It is most rational to use aromatase inhibitors during the course, among which Proviron is especially popular, since this drug does not negatively affect the secretion of growth hormone and increases the concentration of anabolic hormones in the blood by suppressing aromatization. In the last week of the course and 2 weeks after, Tamoxifen should be used as the main component of PCT in the absence of Proviron, the start of Nolvadex administration falls on the 2nd week of the steroid cycle, and ends 2-3 weeks after the end of the cycle, the average dose is 10-20 mg per day. I would like to pay special attention to the common misconception that antiestrogens are recommended to drink after a cycle. The level of estrogens increases at the end of the first week of the cycle, so it is from this moment that you need to start taking!

Clomid: instructions for use of tablets

Clomid is a non-steroidal medicinal product belonging to the group of antiestrogens. It has a dose-dependent effect on the pituitary gland, which is responsible for the production of sex hormones. The drug is used not only in reproductive medicine, but also in sports and bodybuilding to restore the body’s ability to produce its own hormones.

Clomid: Indications for use

Clomid was developed for:

  • Stimulation of ovulation in women suffering from anovulatory cycle
  • Elimination of amenorrhea caused by insufficient gonadotropin production
  • Treatment of androgen deficiency in men and oligospermia
  • Diagnostics of the causes of violation of the gonadotropic function of the brain (pituitary).

In addition, Clomid is actively used in bodybuilding and sports to normalize the body’s work on the production of endogenous hormones after a course of steroids. This application is not provided by the manufacturers of the drug, but is the result of personal experience of men engaged in body building. Therefore, few doctors will be able to advise and prescribe a remedy for this purpose.

Medical property

The active component of Clomid is clomiphene citrate, which belongs to the group of antiestrogenic agents. Use in small doses leads to increased production of gonadotropins: prolactin and hormones with follicle-stimulating and luteinizing effects, which contributes to ovulation.

Use of clomid in bodybuilding

If the body’s estrogen content is low, Clomid has a moderate estrogenic effect, and in the case of a high content – antiestrogenic. Taking large doses activates the production of gonadotropins.

Method of application

The dosage of clomid tablets depends on the purpose of the drug. Clomid regimen for infertility problems:

  • To stimulate ovulation, the instructions for use recommend that women take 50 mg daily (before bedtime). Therapy begins on the 5th day of the monthly cycle. The course is 5 days. If there is no effect, repeat the drug administration (up to 3-6 courses), increasing the dosage to 150 mg or extending the duration of therapy, bringing the course to 10 days. At the same time, it is important not to exceed the total dose for the entire cycle of administration-1 g of the active substance.
  • Infertility in men. Representatives of the stronger sex, experiencing problems with spermatogenesis, it is recommended to take 1-2 times a day for 50 mg. During the course for men, it is mandatory to check the spermogram.

How to take Clomid on PCT

The scheme of recovery with Clomid after a course of steroids depends on its duration and the number of stimulants taken. The higher the dosage of steroids and the longer the cycle lasted, the longer it will take to return the body’s functions to normal.

  • After the ultralight course: 15 days of 50 mg, then the next 15 days of 25 mg
  • After a light course: 15 days. X 50 mg, 15 days. X 25 mg, 15 times (1 time in 2 days) 25 mg
  • After moderate intake: 30 days. X 50 mg, 15 days. X 25 mg
  • After intensive administration: 15 days. X 100 mg, 15 days. X 50 mg, 15 days. X 25 mg
  • After overdose: 3 days. X 150 mg, 12 days. X 100 mg, 15 days. X 50 mg, 15 days. X 25 mg.

To restore the production of their own testosterone, other drugs are also used-antiestrogens. What works best depends on many factors. Basically, several pairs of drugs are compared:

  • Clomid or Tamoxifen? The competing drugs are similar in structure, but the latter drug is stronger. Therefore, it takes less to restore testosterone. However, it is considered that the described remedy is the best choice for PCT after taking progestins.
  • Proviron or Clomid? Both medications have an anti-estrogenic effect, but each of them in its own way. The difference is as follows: Clomid stimulates tissues to release hormones, which increases the level of endogenous testosterone, and Proviron suppresses the enzymes responsible for the transformation of steroid hormones into estrogens. Due to this, the process slows down, which leads to the accumulation of testosterone in the plasma. But the effect is temporary, so after some time, the level of the male hormone will fall again.

Should I drink Clomid on a course of steroids

While taking anabolics, the level of androgens is extremely high, and therefore the body does not need to synthesize its own substances. The hypothalamus stops giving commands to the pituitary gland to produce hormones. As long as the concentration in the body of substances received from outside is maximum, Clomid will not be able to stimulate the body. The drug can only be taken during a steroid cycle as an anti-estrogenic agent.

The drug is prohibited for pregnant and nursing mothers. Women of reproductive age should make sure that there is no pregnancy if Clomid is prescribed.

Clomid precautionary measures

The use of the drug should only take place under the constant supervision of specialists.

The drug stimulates superovulation, which creates favorable conditions for the development of multiple pregnancies.

If ovulation is assumed to have taken place after the reception, but menstruation has not occurred, you should check the woman for pregnancy. Repeated administration of tablets can be carried out only after confirmation of the absence of conception.

Pills can cause decreased mindfulness, drowsiness, and slow reactions. At the time of admission, you should refrain from potentially dangerous activities: driving vehicles or operating complex mechanisms.

Like any medicine, Clomid should not be taken with alcohol, so as not to reduce its effect.

Ovulation stimulation: from indications to prescription.

Long ago in the past, there were times when problems with ovulation in a woman meant only one thing for a married couple — infertility. Medicine has learned to successfully solve this problem, and in many cases, treatment ends with conception and the birth of a healthy child. In this case, ovulation stimulation is performed with drugs that are individually selected for each patient in accordance with her physiological characteristics. We will tell you in which cases the doctor can prescribe ovulation stimulation, what should precede it, what is the scheme of the procedure and its effectiveness.

Why do we need the stimulation of ovulation

Ovulation stimulation is prescribed only if there are direct indications for it, since if the woman’s reproductive system is in order, then she herself produces viable eggs.

Ovulation in a healthy woman of childbearing age is the process of releasing a fully Mature and ready-to-fertilize egg from the follicle. Exit is preceded by a long preparation. Once a month, several eggs sleeping in the ovary are awakened by hormones and begin to increase in size. After about ten days, the dominant follicle is released from them, the size of which can reach 18-20 mm. When the egg is fully Mature, the follicle shell is torn. The egg goes into the abdominal cavity, and then enters the fallopian tube. There, within 24 hours, she waits for fertilization. If it does not happen for some reason, the egg dies and the whole process is repeated in a month. Usually one egg is involved in ovulation, but sometimes there are two or three. In this case, twins are born. If the embryo divides itself into 2 parts after fertilization (that is, initially these 2 parts were formed from one egg and one sperm), then twins are born.

ovulation stimulation

In some women who are ready to become mothers both physically and mentally, pregnancy does not occur because her ovaries do not form a Mature egg. If conception does not occur for 6 consecutive cycles, ovulation stimulation may be prescribed. It has a single goal — to help the body form a full-fledged egg, capable of fertilization, and push it to exit the follicle. The essence of the method is to target the ovaries with certain medications in order to increase the release of hormones necessary for ovulation.

Ovulation stimulation for conception, the doctor prescribes only if there are:

  • Anovulatory infertility (hormonal dysfunction that is incurable in another way; polycystic ovary; a woman’s high or low body mass index;)
  • Preparation for artificial insemination by IVF.
  • Infertility of unknown origin.

Preliminary study

Before starting the ovulation stimulation procedure, the doctor necessarily prescribes a number of studies, both laboratory and instrumental. Their purpose is to identify possible contraindications:

  • hormonal disorders;
  • inflammatory processes of the pelvic organs and ovaries;
  • violations of the patency of the fallopian tubes.

A relative contraindication is the age of a woman over 40 years, because in this case, the risk of giving birth to a sick child increases.

So, instrumental research includes:

  • Examination of the therapist to identify common diseases in which pregnancy is contraindicated.
  • ECG.
  • Ultrasound of the pelvis and mammary glands.
  • Examination of the patency of the fallopian tubes by laparoscopy or radiography with contrast material.
  • Folliculometry.
  • Fluorography.
  • Types of laboratory tests:

Clinical blood test.

  • Blood tests for syphilis, HIV, hepatitis B and C.
  • The General analysis of urine.
  • PCR – examination of smears from the vagina and cervical canal.
  • Examination of smears from the vagina, cervical canal and urethra for atypical cells and the degree of purity.
  • Infectious examination (for chlamydia, ureaplasmosis and mycoplasmosis, gonorrhea, trichomoniasis, etc.).
  • Determination of the blood level of female sex hormones, thyroid hormones, prolactin and testosterone (performed repeatedly).

After a full examination and obtaining a medical opinion on the absence of diseases that can prevent conception or provoke the birth of a sick child, it is necessary to assess the ovarian reserve of a woman. Using this procedure, is defined by:

  • the chance to receive in the process of stimulating ovulation of a positive result;
  • intensity of stimulation;
  • optimal scheme;
  • the most effective drugs and their individual dose.

To assess the ovarian reserve, a woman gives blood for analysis after taking hormonal drugs. Based on the obtained indicators, a conclusion is made about the prospect of artificial ovulation stimulation.

The choice of the scheme of hyperovulation

Ovulation stimulation is performed according to one of the regulated schemes, which describes in detail the method, dose and duration of administration of the drug. The doctor selects the scheme taking into account:

  • result of ovarian reserve assessment;
  • female body mass;
  • the results of the previous stimulation procedures (if any).

All drugs used for stimulation are hormonal, but differ from each other in the type of hormone they are based on — follicle-stimulating or luteinizing (necessary to support the development of the egg). There are four groups of tools for ovulation stimulation.

  • Preparations based on HMG (human menopausal gonadotropin), containing follicle-stimulating (FSH) and luteinizing (LH) hormones in the same proportion. This includes, for example, “Menopur”.
  • Drugs based on FSH, whose principle of action is close to the natural hormone — “Gonal”, “Puregon”.
  • Drugs that are based on the suppression of estrogen and increase the level of FSH to the required norm — “Clostylbegit”, “Clomid“, “Clomifen”.
  • Hormonal agents that stimulate the rupture of the follicle shell and the timely release of the egg – “Prophase”, “Horagon”, “Pregnil”, “Ovitrel”.

Usually, a combination of drugs is used in the schemes.

Ovulation stimulation is recommended to be performed no more than 6 times, since it can lead to depletion of the ovaries. If the desired pregnancy does not occur as a result of stimulation, it is necessary to choose other methods of treatment.

Despite the fact that ovulation stimulation is a well-established method of treating infertility, it should be remembered that it also has its own limits of application, indications and contraindications, and side effects. In addition, even if it did not lead to the long-awaited result, it is important to know: modern Reproductology is not limited to this method.