Clomiphene ™

The main purpose of Clomid is to induce ovulation in women who do not ovulate or do not ovulate regularly. Between 70 and 80 percent of women taking Clomid will ovulate during the first cycle of treatment. Of course, ovulation is only the first step. Your chance of getting pregnant within a few cycles is approximately 35 percent. If you haven’t gotten pregnant in six months, it’s time to switch to another treatment.

What are the chances that Clomid will work in the first month?

Depending on which studies you refer to, the probability of conception within a single cycle of Clomid treatment is between 7 and 30 percent. The effectiveness of Clomid varies depending on the cause of infertility.

Keep in mind that those who do not have fertility problems are about 25 percent more likely to get pregnant in any given month. If you don’t get pregnant in a month, don’t panic. The need for more than one cycle is common.

What are the chances of getting pregnant after many cycles on clomid?

A literature review published in the journal Human Reproduction reviewed several studies on clomid. In total, Clomid success rates for more than 5,000 women were included. In this study, they found that:

• 73 percent eventually ovulated on clomid
• 36 percent eventually reached pregnancy
• 29 percent gave birth

The birth rate is lower than the pregnancy rate due to miscarriages. Clomid does not seem to increase the risk of miscarriage.

Other studies have reported that when using Clomid, the percentage of successful pregnancies is between 30 and 40 percent. Again, the birth rate will be lower due to pregnancy loss.

However, the success of Clomid (clomid ovulation) also depends on why you can’t get pregnant. Clomiphene citrate may work well for people with ovulation problems. But what if ovulation isn’t a problem?

Another study, conducted in Scotland, looked at success rates for couples who were found to have infertility. The couples were randomly assigned to one of three groups: “wait-and-see”, clomid-only treatment, or clomid with IUI. The most effective treatment group was the IUI plus Clomid group, which achieved a 22 percent fertility rate. The clomid – only treatment group did the same with couples who received no treatment at all.

Does the day you start treatment with clomid matter?

Clomid is taken for five days. Treatment can be started as early as the 2nd day of the menstrual cycle or as early as the 5th day. However, most doctors either prescribe clomid on days 3, 4, 5, 6, and 7, or take it from you on days 5, 6, 7, 8, and 9.

Does it matter which protocol your doctor chooses? Yes and no. In order to cause ovulation, treatment is carried out from day 5 to day 9. If your doctor wants to” improve ” ovulation, you will probably take Clomid on days 3 to 7.

However, when it comes to pregnancy and ovulation success rates, studies have found no advantages or disadvantages.

Your chances of getting pregnant are the same, regardless of which protocol your doctor prefers to start taking Clomid.

Remember that while you may be mostly familiar with clomid treatment and possibly IVF, there are actually many more infertility treatment options that you should consider. Always talk to your doctor if you’re concerned about the next step or if Clomid isn’t working as well as you hoped.

Clomiphene citrate (Clostilbegit, Clomid, and other trade names) is a fertility drug that has been used since the 1950s. Dr. mark P. Leondires of the Association of reproductive medicine of Connecticut claims that the drug was originally used for the treatment of breast cancer because it has anti-estrogenic properties. However, clomiphene has also been found to help induce ovulation, and there is a long and close association between it and pregnancy. As a result, it has since been used as a drug to stimulate natural ovulation in women who want to get pregnant.

In what cases can clomiphene help you get pregnant?

When it comes to clostylbegitis and pregnancy, who can take the drug and under what conditions?

Polycystic ovary syndrome

Doctors usually recommend clostilbegyt for the treatment of disorders of ovulation due to polycystic ovary syndrome (PCOS).

Infertility in violation of the menstrual cycle or ovulation

In addition, it can also be used to stimulate ovulation in women with unexplained infertility – in the event that, despite the normal physical condition and good laboratory results, it is not possible to conceive a child. Clomiphene is also sometimes used in combination with metformin (Glucophage, Siophor, and other trade names), a drug commonly used to regulate insulin levels, which can further promote ovulation.

In the case of assisted reproductive technologies

Clomiphene can also be used before applying various reproductive technologies to achieve pregnancy, including artificial insemination techniques to increase the chances of pregnancy.

What is the percentage of successful pregnancies when using clomid?

Although this drug is medically approved, and there is a long-known and close relationship between clomiphene and the onset of pregnancy, there is no conclusive evidence of its effectiveness for every woman. If you are trying to get pregnant, you will probably want to know if taking clostylbegit will help you to stimulate ovulation and conceive a child.

Some studies show that treatment with clomiphene in women with ovulation problems can lead to the fact that in most of them (about 80%) the egg is released from the ovaries during the first cycle of taking the drug.

However, ovulation does not mean pregnancy. The chances of getting pregnant during the first cycle are only 30%. And yet, this is almost the same as the usual chances of conceiving a child (25%) in couples who do not have fertility problems. Almost half of the couples treated with klostilbegit, it is possible to conceive during the first six months.

Therefore, you should not be disappointed if you do not get pregnant in the first month of treatment. Treatment with clomiphene is usually limited to 6 consecutive months.

How to get pregnant quickly on clomiphene?

There is some connection between taking clomiphene and pregnancy, as this drug may be effective for some women who want to conceive a child. But the question arises, how quickly to take advantage of this?

• Get the recipe – It is necessary to obtain a doctor’s prescription for the purchase of Clostylbegite or another analog. However, before the doctor writes a prescription, he will first evaluate how appropriate it is. Women who have been trying to get pregnant for less than a year may be advised to wait until treatment begins.
• You can save money by buying more affordable analogues – Such medications are not covered by insurance, and it may take several procedures before the attempt to conceive a child is successful. Instead of buying the brand Clomid or Clostylbegit, you can save money and request a prescription for more affordable analogues.
• Take the drug as prescribed – Tablets clostilbegyt or clomiphene is usually taken from the third to the seventh day of the menstrual cycle. However, some doctors may advise taking them on the fifth or ninth day of the cycle. It is important to remember that the 1st day of the cycle is the day when true menstrual bleeding (menstruation) begins, and not daub (light spotting).
• No need for a daily ultrasound – Your doctor may suggest you to follow the effect of receiving clomiphene for ovulation, every day of the ultrasound examination. This procedure does not guarantee that pregnancy will occur. So, this is just an expensive way to monitor, and you can opt out of it to save money.
• Sex every other day – Starting from the seventh day of the cycle, you can plan sexual acts every other day, so that spermatozoa have time to form in the partner’s body. Avoid having more frequent sex, as this can reduce your chances of getting pregnant.
• Make sure to start ovulating with a test – To check whether ovulation has started, you can use a special test for this. You can buy it without a prescription. He is able to show that it is time for conception. If the ovulation test is positive, sexual intercourse should continue for two consecutive days. After that, you should return to the normal schedule.
• Check if you are pregnant – On the 28th day or later, with the help of a home pregnancy test, you can check how successful the treatment is. You don’t have to wait too long to find out!

Negative consequences from trying to get pregnant with Clostilbegyt

Although there is a link between taking Clostylbegit and pregnancy, side effects may occur when using it, and they should be given special attention.

Minor side effects

Like all other medications, clostylbegit can cause some side effects. These include abdominal pain and swelling, weakness, nausea, vomiting, insomnia, blurred vision, fatigue, headache, depression, and weight gain. Some women may develop ovarian cysts.

The birth of twins

Women who are treated with fertility drugs have a 10% chance of having twins. This is due to the release of more than one egg per cycle as a result of drug stimulation of ovulation. In rare cases, triple or even larger multiple pregnancies also develop, which can increase the risk of complications such as miscarriage.

Emotional aspects

Infertility treatment can be a source of emotional stress due to waiting and the lengthy treatment process. Therefore, a woman will need the support of a partner or friend to go through all the doctor’s examinations and follow-up steps related to treatment.

Ovarian hyperstimulation syndrome

The use of clomiphene citrate together with other powerful fertility drugs sometimes leads to the development of ovarian hyperstimulation syndrome (OHSS). This condition is characterized by bloating and increased body weight. Some women also experience shortness of breath, pelvic pain, dizziness, nausea, and vomiting. This condition occurs when the ovaries produce multiple eggs. At the same time, they become several times larger than their normal size, releasing fluid into the abdominal cavity. Usually, no treatment is required, although in some cases, hospitalization may be required for monitoring.

Ovarian cancer

While this is a concern, research shows that using fertility drugs does not necessarily increase the risk of ovarian cancer, even if the course takes more than 12 months.

Does ovulation happen before menstruation – this question torments a lot of women. Fertilization of the egg is possible only if ovulation occurs before the cycle. The best time for pregnancy is in the middle of the menstrual cycle. Ovulation before menstruation occurs, but very rarely, in such cases, two eggs mature, and a woman can give birth to twins. In this case, this may occur either due to the onset of repeated ovulation, or due to a failure of the cycle.

How long before the appearance of bloody discharge should ovulation occur

After a follicle has formed in the ovary, the inner lining of the uterus begins to increase. After that, the egg enters the fallopian tube, this moment comes about two weeks after menstruation, until the 16th day before it. These processes are extremely important for the intended fertilization of the egg.

After the egg enters the body of the uterus, spermatozoa also penetrate here, also through the fallopian tube, only on the other side. Only after the meeting of the egg with the sperm is fertilization performed. If this does not happen, the egg is excreted by the body outside, that is, menstruation occurs. It turns out that you can get pregnant a week before your period, although the chances are not so great. 5 days before their onset – even less.

Gynecologists believe that the optimal cycle of menstruation is 28 days, the time for conception is the middle of the cycle. At this point, everything is in place for a successful fusion of the egg with the sperm.

How long does the ovulation period last

Those women who plan to conceive, keep a calendar of ovulation dates. And this is correct: in order for conception to occur for sure, you need to know the period and duration. Based on the total duration of menstruation, the ovulatory period occurs:

• with a cycle of 21 days for 5-9 days;
• with 25 after 9-13 days;
• with 30 for 16-20 days;
• with 35 for 19-23 days.

Provided that the monthly regularity does not differ, then it is extremely difficult to correctly calculate the day of the onset of the ovulatory period. In this case, it is better to use other, more accurate methods of deduction. It lasts for each woman in different ways.

Answering the question whether there can be ovulation before the most monthly, we come to an unambiguous – in most cases it can not. It happened that women got pregnant before their periods – such cases are very rare.

Gynecology knows cases when women get pregnant on the day of the cycle, which is considered completely zero. This is explained by changes in the hormonal background, this happens against the background of emotional state, stress and other factors.

Due to severe stress, the menstrual cycle can shift, affecting the period of ovulation. As a result, two ovaries are able to secrete an egg. Not necessarily on the same day, it can happen on different days, and pregnancy will occur during menstruation.

Can it come sooner

In cases where a woman’s cycle is 35 days, even if she is absolutely healthy and her monthly periods come regularly, the release of a mature egg may occur earlier. And the fertile period-later for a week or a little longer.

This can provoke:

• Hormonal disorders in the body.
• Emotional overstrain and stress.
• Weakened immune system.
• Exacerbation of chronic diseases.
• Violation of metabolic processes Overeating or, conversely, starvation.
• Sudden climate change.
• Heavy physical activity

The fertile period may also shift due to the withdrawal of contraceptive drugs, after an abortion or due to a miscarriage.

Does the absence of ovulation before pregnancy mean conception

You can conceive a child only when a woman has matured an egg. The absence of ovulation indicates that this process does not occur in the body of the expectant mother. This means that there can be no question of any pregnancy. In such cases, you need to go to the gynecologist and find out the cause of what is happening. The root cause of this may be a hormonal imbalance.

You can correct it with a specially selected therapy. If the cause cannot be established, doctors resort to radical methods, for example, during the period of alleged ovulation, the patient is injected with a drug that causes the formation and maturation of the follicle with the further release of the egg.

Is it possible to fertilize an egg after ovulation

No, a miracle, in this case, will not happen. A day after ovulation, women have a period that gynecologists call absolute infertility. For those who do not know the answer to the question of whether there can be ovulation before menstruation, we explain the essence of what is happening during the ovulatory period.

Ovulation divides the monthly cycle into two parts. The first is the phase of follicle maturation (duration, on average, 6-9 days). The second is the yellow body phase, the duration of this period lasts, depending on the cycle, and is, on average, 14 days. The second refers to the period of absolute infertility.

Pregnancy does not occur because a mature and ready-to-fertilize egg lives only 24 hours. Sometimes it can live even less. After it begins to collapse.

Can the ovulatory period occur before menstruation

The moment when the egg enters the uterus depends on the hormonal level and the duration of the follicular phase. In some young girls, these processes are very slow. Ovulation and pregnancy before menstruation are possible, due to the fact that the first phase becomes a little longer than usual. The primary cause of this may be a deficiency of the hormone estradiol. The moment of ovulation in such cases falls on the day of the beginning of menstruation, and the cycle itself should move.

Menstruation can not begin at the time of rupture of the follicle, because here comes the luteal phase, which lasts 14 days plus / minus 2 days.

If the ovulation period occurred at the beginning of the cycle and at this point the couple had unprotected contact, then the probability of fertilization remains high. In women in such cases, it is believed that ovulation occurred just before menstruation. In fact, the cycle, or rather its duration, has increased due to the follicular phase.

Probability of fertilization a week before the cycle

If pregnancy is not included in the family plans, then you need to be protected before the cycle constantly, even for a week. Although ovulation can not occur a week before menstruation, there is a chance of fertilization. This applies to young girls and women on the verge of menopause. In medical practice, such cases have happened. The reason for this may be too long periods, irregular cycles or severe stress loads.

The calendar schedule of pregnancy protection in such cases does not work, the probability of unwanted fertilization increases. In cases where the release of a mature egg fell on the period a week before the cycle, the woman must necessarily feel the characteristic symptoms of the fertile phase.

Is there a chance of pregnancy a day or two before the cycle

Many women believe that this is impossible. This statement is false, in fact, there is such a probability, although it is scanty. If a woman is absolutely healthy, then the greatest chances of pregnancy, namely 95%, fall in the middle of the cycle, the chance of fertilization of the egg a day before menstruation is reduced to 1 %, but it still exists. Gynecologists believe that unwanted pregnancies in women occur due to the fact that they simply incorrectly calculate the ovulatory period or because of a violation of the cycle itself.

Can ovulation be more than once

In almost all healthy women, ovulation occurs repeatedly during their lifetime. The regularity of the cycle does not play any role here. The approximate time of the second one is 24 hours or 2/3 days after the first one. The maximum difference is 1/1. 5 weeks in the same cycle. This fact is explained by the fact that both ovaries simultaneously matured eggs. At the time of release, the second hormone level decreases, but the probability of fertilization remains.

In conclusion: ovulation before menstruation

Summing up all the above, it can be noted that even the healthiest representative of the fair sex can have shifts in the ovulatory phase – this is the answer to the main question, which was mentioned above, whether there can be ovulation a week before menstruation, a day or just before them.

Such deviations are temporary, most often the regularity of the cycle is restored by itself. If this is a consequence of pathological changes in the body, then you can not do without the help of doctors.

Coronavirus in pregnant women: Infection with COVID-19 during pregnancy can affect not only the health of the mother, but also the development of the child, according to obstetricians and gynecologists. So, the coronavirus can affect the slowing of fetal growth, provoke incorrect laying of its vital organs, and also lead to prematurity of the child.

Is coronavirus dangerous for pregnant women?

If a woman has contracted a coronavirus infection in the second trimester of pregnancy, this can lead to a slowdown in the development of the fetus.

At the same time, there is a possibility that the effect of CAVID-19 on the child will continue after the recovery of the expectant mother, the expert believes. “So, in the first trimester, a virus carried by a pregnant woman can affect the growth of the fetus, and in the second — cause a slowdown in the development of the child,” the doctor said.

According to her, such consequences are associated with respiratory failure – in a woman in the late stages of pregnancy, the stomach presses on the lungs, thus reducing their volume.

In addition, the coronavirus also affects red blood cells (red blood cells that supply the body with oxygen).

“Red blood cells lose the ability to carry oxygen, respectively, the fetus begins to experience oxygen starvation, so automatically slows down and its growth and development»

Coronavirus in pregnant women: facts

Experts believe that only patients who have COVID-19 in moderate to severe forms, and it is during the second or third trimester, should be afraid.

According to the doctor, with this course of the disease, the fetus may be so short of oxygen that doctors — in order to alleviate the condition of the child — often resort to terminating the pregnancy by caesarean section.

In this case, the woman herself often suffers from the inability to breathe, so this operation is also carried out in order to save the life of the woman in labor, Marian Knight, a professor at Oxford University in the UK, previously told the BBC.

Ed Mullins, a British gynecologist at the Queen Charlotte and Chelsea Hospital, also stated that when the fetus develops distress syndrome, childbirth is accelerated artificially. “This is done in order to provide more effective treatment for low oxygen levels in a woman,” the medic explained.

Transmission of the virus

As for the transmission of coronavirus from mother to child in utero, such cases have not yet been recorded. “The fetus is not a direct target for COVID-19. The virus has no proven teratogenic effect (disruption of embryonic development due to external factors) on the fetus. The placental barrier is really good for him. As a rule, children are born healthy».

She added that in order to avoid serious disorders in the body of a pregnant woman and fetus, expectant mothers with coronavirus should be isolated in time and placed under medical supervision. “Remember that stress is the main danger of a successful pregnancy. Do not read unverified news, follow all hygiene measures and be positive, ” the medic said.

Ovulation is the threshold of conception and pregnancy. This is the period of maturation of the female sexual egg. There is no ovulation process — there is no pregnancy. Can ovulation occur during pregnancy? Does clomid help ovulation?

When an egg Matures in the follicle of the female ovary, it leaves it and goes through the fallopian tubes to the uterine cavity. This process is called ovulation and means the readiness of the woman’s body to conceive. Against this background, hormonal changes occur, which are accompanied by painful and aching sensations in the lower abdomen, thick vaginal discharge. It is during ovulation that a female egg can be fertilized by a male sperm during sexual intercourse. If this did not happen, conception did not take place, then it is removed from the body after a while. This is the period of menstruation — the beginning of the menstrual cycle.

When an egg is fertilized by a sperm during ovulation, it moves up the fallopian tube again and attaches to the wall of the uterus. Pregnancy occurs, the embryo develops. It is logical that the female body directs all its forces to the healthy bearing of the baby. At the same time, for 9 months, the eggs no longer Mature. It is so arranged by nature that after the onset of an “interesting” position, ovulation can harm the woman and the embryo.

Once fertilization has already occurred, the production of new eggs is no longer needed by the woman’s reproductive system. Her body is rebuilt: the ovaries do not produce eggs, the cervix is blocked by a specific mucous membrane, and sperm can no longer show activity in it.

Ovulation occur during pregnancy – Exception to the rule

If we still assume that ovulation during pregnancy is possible and a new conception can occur, then the fetal egg simply cannot attach to the uterus, because the embryo is already developing there.

There are no rules without exceptions. Therefore, sometimes the process of ovulation occurs when carrying a baby. But only in the first month of pregnancy. At its early stage, there is a possibility of a second egg coming out of the ovary and fertilizing it. To date, several cases of re-fertilization after pregnancy are known. But these are the rarest exceptions to the rule. That is, a woman can not bear two embryos at the same time with different terms of conception. A multiple pregnancy is the carrying of two or three babies conceived at the same time. They are born in the process of one birth, one after another.

About ovulation tests

Today, they help couples who want to have a child and try to determine whether the female body is maturing eggs, use the optimal day for conception.

All ovulation tests are based on the same principle. Their effect is to change the color of the indicator strip as a result of getting luteinizing hormone. Its level during ovulation is the highest, which is what the test responds to. So can it happen that a pregnant woman’s ovulation test will show a positive result? Practice shows that this is excluded. Such a test cannot be positive for the expectant mother. However, the same practice confirms that due to their inattention, many representatives of the weaker sex use a different test — for pregnancy. That’s why the result is positive. And this is quite natural. After all, the task of such a diagnostic method is to confirm the “interesting” position. It is confirmed by the presence in the blood of the pregnancy hormone-chorionic gonadotropin. The indicator strip of the pregnancy test responds to its presence.

The ovulation test can be false positive, that is, unreliable, in some cases. We are talking about kidney failure, hormonal dysfunction of the body, postmenopause. Then it is possible to increase the level of luteinizing hormone in the blood.

So, the onset of ovulation in pregnant women is impossible, so it is already laid down by nature. Therefore, during this period, during intimate relationships, contraceptives are no longer used— there is no need for them.

Clomiphene (clomiphene citrate), commonly known under the brand names Clostilbegit and Clomid – is a drug that is prescribed for ovulation and fertility disorders. This pharmacological agent can be used by women who do not ovulate, as well as those who have a lack of luteal phase. LH (luteinizing) and FSH (follicle-stimulating) are hormones that control the ovulation process. Various clinical and scientific studies have provided statistics that consumption of clomiphene stimulates the pituitary gland to produce more of these all-important hormones to normalize ovulation.

In modern times, clomiphene, discovered back in 1956, and ovulation continue to be closely related, as the drug has proven effective for ovarian stimulation and is therefore widely used for this purpose. Other drugs that also stimulate the process of egg release from the follicle are bromocriptine and metformin.

How does clomiphene work?

the body’s cells exchange information through substances such as hormones and neurotransmitters (neurotransmitters). they come into contact with the receptors of various tissues to cause a chemical reaction.

The mode of action and mechanism of the drug are quite similar to the female sex hormone-estrogen. Similarly, clomiphene comes into contact with a receptor present in the hypothalamus (an endocrine gland located in the brain). the drug blocks estrogen from showing its biological properties, while the body believes that this hormone is not enough. this automatically causes the body to produce more gnrh (gonadoliberin), which in turn causes the release of lh and fsh. In fact, FSH helps in the maturation process of follicles (or potential eggs) and therefore produces more estrogen. If clostilbegyt operates so that ovulation occurs more frequently.

How effective is it?

According to statistics, 70% of women report positive results within 6 months after the start of using the product, as evidenced by the solution of issues with ovulation. In addition, about 40% of women are reported to be able to conceive a child after starting treatment. There are several other factors that can affect the chances of getting pregnant, such as a woman’s age and weight. In addition, the period of the menstrual cycle, the frequency of sexual intercourse and male factors such as mobility, speed, shape and number of sperm can also influence the ability to get pregnant. The doctor may increase the dose over time to increase the chances of conceiving a child, as a low dose may not be sufficient for some patients.

Clomiphene and ovulation: what are the side effects?

In addition to the positive effect of clomiphene, as with many other drugs, there may be some side effects:

• Breast sensitivity;
• Significant weight gain;
• Blurred and blurred vision;
• Changes in normal sleep quality and rhythm;
• Abdominal pain;
• Mood swings;
• Severe bleeding during menstruation;
• Spotting;
• Sensations of a rush of heat;
• Nausea;

Another side effect of clomiphene is dryness of the cervical mucosa, which can affect the quality of sexual intercourse; however, this defect can be compensated by the use of vaginal lubrication.

As a side effect, OHSS (ovarian hyperstimulation syndrome) may occur. This condition is characterized by a reversible increase (edema) of the ovaries due to an active reaction of the body to hormones and is quite common (> 10% of women). OHSS should be suspected if excessive flatulence or bloating occurs. This can be a serious problem, but usually ovarian hyperstimulation syndrome that occurs due to the use of clostylbegit is a mild condition that goes away on its own. The severity of OHSS may increase if you take HCG (another fertility medication).

Clomiphene can lead to multiple ovulation, hence increasing the likelihood of twins (10% of births instead of – 1% without it) and triplets.

Some studies have shown that clomiphene, when used for more than a year, can increase the risk of ovarian cancer. Subsequent studies have not confirmed these findings, so we can not speak confidently about this.

According to statistics, the incidence of fetal diseases with the use of clomiphene does not exceed the level that is observed in conception without it. There are no data indicating a higher number of congenital abnormalities or spontaneous abortions after using this drug. although there are also studies that show that the number of congenital heart abnormalities is significantly higher with its use than with its counterpart for ovarian stimulation – letrozole.

Sexual acts when taking clomiphene

The period and frequency of sexual acts when using the drug is not much different from trying to get pregnant without any medication. The ideal time is considered to be two days before and after ovulation, so that the chances of pregnancy increase. The cycles of egg release from the ovary can vary, as in some women they are longer, while in others they are shorter. The ovulation period may even differ from cycle to cycle in the same woman. You can be disappointed if you get too hung up on conception, so it’s better to just relax and try to implement interesting ideas in the bedroom.