Stimulation of ovulation

Ovulation is the natural process of an egg entering the fallopian tube after a Mature follicle is ruptured. Usually occurs 14 days before the start of menstruation. For a number of reasons, the egg may not be released from the follicle. In this case, artificial ovulation stimulation is required.Specialists of the IVF reproductive health clinic use dozens of techniques aimed at maturing the follicle and releasing the egg into the fallopian tube. Doctors prescribe medications (“Clomid“, “Didrogesterone”, etc.), select a diet, eliminate hormonal imbalances, give recommendations for lifestyle correction. As a result of complex therapy, a woman begins to ovulate, which is necessary for the conception of a child.

Features of the ovulatory phase

In healthy women, the rupture of the follicle with the subsequent release of the egg into the fallopian tube occurs without stimulation about 14 days before the onset of menstruation (with a 28-day cycle). Small deviations from the average are often observed and are considered the norm.

ovulatory phase

On the eve of ovulation, the ovarian follicle increases in size to 2 cm in diameter. At this point, the egg Matures in it. Under the influence of hormones, a gap appears in the follicle. Through it, the egg enters the oviduct (fallopian tube), and then – into the uterus, where fertilization occurs. The duration of the entire process does not exceed 48 hours. However, many women of reproductive age have disorders in the ovulation phase. This makes it difficult to conceive a child.

Indications for the procedure

Doctors of the IVF reproductive health clinic prescribe ovulation stimulation after laboratory and instrumental diagnostics. Therapy is indicated for women who have detected anovulation caused by:

  • polycystic ovary;
  • hyperandrogenism;
  • resistant ovarian syndrome;
  • hormonal disorders in diseases of the endocrine system;
  • hypothalamic-pituitary dysfunction;
  • pathologies of the reproductive system from prolonged use of contraceptives and hormonal agents.

Ovulation stimulation is indicated after undergoing a comprehensive diagnosis, which is aimed at detecting the cause of abnormalities in the menstrual cycle.

Preparing for the procedure

Before ovulation stimulation, it is necessary to undergo a clinical diagnosis. First of all, a woman is assigned to pass laboratory tests. These include:

  • venous blood analysis for detection of antibodies to pathogens of syphilis, immunodeficiency virus, toxoplasmosis, chlamydia, cytomegalovirus, rubella;
  • urine sampling for the diagnosis of trichomoniasis and vaginal candidiasis;
  • vaginal smear to detect mycoplasmosis, Gardnerella, pathologically altered cells;
  • urine analysis to determine the indicators of prolactin, estrogen, and testosterone.

Preparing for the procedure

Also shown is the conducting of instrumental diagnosis of. Patients are referred to:

  • General examination by a therapist;
  • Examination by a gynecologist;
  • ECG (under load and in a relaxed state);
  • Ultrasound of the pelvic organs – this method helps to detect organic pathologies, malignant and benign tumors;
  • X-ray of the fallopian tubes-necessary for the diagnosis of obstruction;
  • Folliculometry – this method of ultrasound allows you to track the growth and development of follicles in dynamics.

Doctors of the IVF reproductive health clinic select treatment individually depending on the causes that caused the abnormal course of the menstrual cycle.

What is ovulation induction?

This is a procedure in which specialists artificially stimulate the maturation of eggs. During induction, both one and several cells can develop in the follicles of a woman. Such treatment should be performed with IVF or insemination. The more Mature eggs a reproductologist extracts from a woman’s ovaries, the higher the chance of a successful outcome of in vitro fertilization. Induction can be performed with medication.

Methods of artificial stimulation

In medical practice, there are many ways to speed up the process of maturation of the egg and follicle. Particularly effective are:

  • drug therapy-involves the appointment of drugs that normalize the production of female hormones, restoring the menstrual cycle;
  • diet-nutrition correction helps restore metabolic processes, increase the body’s support forces;
  • vitamin therapy-aimed at eliminating the deficiency of vitamins (A, D, C, E, etc.), as well as macro – and microelements (iron, zinc, calcium, phosphorus).

Stimulating the ovulation process in several ways increases the chances of restoring the menstrual cycle and further conception of a child.

Medication

When detecting pathologies in the maturation of follicles and eggs, specialists use drugs to stimulate ovulation. Funds are selected based on the patient’s age and weight, as well as the cause of the violation. In addition, the choice of a specific drug depends on the further method of fertilization of the egg (natural, IVF, ICSI, IMSI, etc.).
Medication prescribed to stimulate ovulation does not give results immediately. Only 15% manage to get pregnant after a short course of medication. Specialists of the IVF clinic psychologically prepare women and introduce them to statistics in order to reduce stress in the event of a failed attempt.

Nutrition for successful ovulation

Food is the main source of nutrients, macro-and microelements. The diet significantly affects the menstrual cycle and the ability to conceive. Women who consume a lot of fat and carbohydrates can suffer from overweight, high cholesterol, and diabetes. Such diseases negatively affect the work of the reproductive system. Lack of body weight is also dangerous – the body reduces the concentration of female hormones (estrogen, progesterone, prolactin, etc.).

Nutrition for successful ovulation

Specialists prescribe proper nutrition to stimulate ovulation, recommending that the menu include:

  • dairy products (cottage cheese, hard cheeses, milk);
  • fruits / vegetables rich in fiber, trace elements and vitamins;
  • the wheat germ;
  • legumes (chickpeas, beans, peas);
  • quail eggs;
  • walnut;
  • flax, sesame and pumpkin seeds;
  • dates.

In the course of treatment, it is necessary to stop using alcohol and Smoking. Certain foods prescribed by the diet may cause alle.

Clomid – instructions for use for women

Clomiphene citrate (clomid) is a synthetic non-steroidal drug that resembles estrogen in structure. It is widely used as an ovulatory stimulant. Having a similarity to estrogen, it can bind to estrogen receptors in the hypothalamus. This prevents the hypothalamus from detecting “real” estrogen, and the hypothalamus, in turn, causes the pituitary gland to secrete more gonadotropins, such as FSH and LH. FSH and LH stimulate the ovaries, the testes to produce more estrogen in women or testosterone in men.

This property of clomiphene is widely used in the treatment of women with premature loss of ovarian function and for the induction of ovulation. However, long-term use of this drug is not safe, as it increases the risk of ovarian cancer.

Pharmacology

Clomid is recommended for the treatment of women with ovarian dysfunction. Many women who fail to get pregnant have a disrupted ovulation process. Among patients with ovulation problems, there are patients with polycystic ovary syndrome and patients with unknown causes of amenorrhea. Clomid is prescribed only after a complete study of the menstrual cycle and determining the cause of the violation.

In the treatment of clomid, the time of reception is of great importance. To determine ovulation, the blood is examined and the body temperature is checked. If the fact of ovulation is established, start taking clomid. As a rule, clomid is prescribed on the fifth day of the cycle. Usually clomid is taken for 3-6 cycles. Long-term treatment with the drug is not recommended.

Mechanism of action of clomiphene

Clomid is a powerful medication. However, if the correct dosage and short treatment periods are observed, it can help with female infertility. Clomiphene is similar to estrogen. It interacts with estrogen receptors in the hypothalamus and blocks these sites. In this case, the brain receives a signal about the insufficient amount of the hormone estrone in the body. This causes an increase in the level of gonadotropins, which increase ovarian stimulation for the production of estrogens. This leads to the synthesis of the hormone in both the adrenal glands and ovaries. Increasing the level of estrogen is important for the fertilization process.