When using assisted reproductive technologies (ART), as a rule, hormonal drugs (IVF pills) are used. IVF preparations are chemical compounds obtained synthetically, which have the same effect on the body as their own sex hormones.
The drugs are used at the stage of ovulation stimulation, to prepare the endometrium for embryo transfer, as well as to support the luteal phase in early pregnancy.
Below we will look at these medications, but the information on them is in no way a prescription and can not be used by patients on their own without the appointment of the attending physician. Our article is for informational purposes only.
Preparations for ovulation stimulation
Antiestrogens
Clomid (clomiphene, clomiphene citrate, clostylbegite). It is available in tablets of 50 mg. In small doses, it increases the secretion of gonadotropins (prolactin, FSH and LH), stimulates ovulation; in high doses, it inhibits the secretion of gonadotropins. It is used both to stimulate ovulation under the control of ultrasound, and in IVF protocols.
Human Menopausal Gonadotropins
IVF pills: Menopur containing 75ED FSH and 75ED LH (Ferring, Germany). Currently, there is a Menopur-Multidose containing 1200 units of FSH and 1200 UNITS of LC, with the ability to dose the drug using a convenient handle.
Menogon containing 75ED FSH and 75ED LH (Ferring, Germany).
Alterpur-urofollitropin (FSH) , available in doses of 75 and 150 IU; (Ibsa, Switzerland). e
Merional (Ibsa, Switzerland), The ratio of the biological activity of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) is 1:1. It is available in a dose of 75ME and 150ME (the dose is measured by FSH).
Bravel (Ferring, Germany) – urofollitropin (a highly purified follicle-stimulating hormone), is available in a dose of 75 MG FSH.
Previously existing menotropins-Pergonal, Metropin, Humegon – are not currently produced.
The use of estrogens in ART
Estrogens in transdermal (through the skin) or oral (through the mouth) forms are used:
- in programs using cryopreserved embryos
- in protocols of superovulation stimulation
- in patients with endometrial hyperplasia in surrogacy programs.
IVF pills: Proginova 2 mg (Delfarm, France) – dragee for oral administration.
Estrofem 2 mg (NOVO NORDISK, Denmark) – tablets for oral administration.
Divigel 0.5 and 1.0 (Orion Corporation, Finland) – gel for external use in single-dose packages.
Estrogel 2.5 mg (Besins, Belgium) – gel for external use, contains 1.5 mg of estradiol in tubes of 80 g with a measuring spatula.
The Council of Experts of the RARCH (Russian Association of Human Reproduction) recommends continuing estrogen therapy during the first trimester of pregnancy in the absence of their own yellow body, its functional insufficiency or endometrial hypoplasia.
When making a list of drugs that we use in our work, you can not choose the best one or make a universal scheme of stimulation. Depending on the clinical situation, the doctor individually selects the drug and its required dose.
! Attention ! All information on the drugs presented in this article is not intended as a prescription and cannot be used by patients independently without the appointment of the attending physician. The article is for informational purposes only.