Clostilbegyt (clomiphene) and pregnancy – what you need to know

Clomiphene citrate (Clostilbegit, Clomid, and other trade names) is a fertility drug that has been used since the 1950s. Dr. mark P. Leondires of the Association of reproductive medicine of Connecticut claims that the drug was originally used for the treatment of breast cancer because it has anti-estrogenic properties. However, clomiphene has also been found to help induce ovulation, and there is a long and close association between it and pregnancy. As a result, it has since been used as a drug to stimulate natural ovulation in women who want to get pregnant.

In what cases can clomiphene help you get pregnant?

When it comes to clostylbegitis and pregnancy, who can take the drug and under what conditions?

Polycystic ovary syndrome

Doctors usually recommend clostilbegyt for the treatment of disorders of ovulation due to polycystic ovary syndrome (PCOS).

Infertility in violation of the menstrual cycle or ovulation

In addition, it can also be used to stimulate ovulation in women with unexplained infertility – in the event that, despite the normal physical condition and good laboratory results, it is not possible to conceive a child. Clomiphene is also sometimes used in combination with metformin (Glucophage, Siophor, and other trade names), a drug commonly used to regulate insulin levels, which can further promote ovulation.

In the case of assisted reproductive technologies

Clomiphene can also be used before applying various reproductive technologies to achieve pregnancy, including artificial insemination techniques to increase the chances of pregnancy.

What is the percentage of successful pregnancies when using clomid?

Although this drug is medically approved, and there is a long-known and close relationship between clomiphene and the onset of pregnancy, there is no conclusive evidence of its effectiveness for every woman. If you are trying to get pregnant, you will probably want to know if taking clostylbegit will help you to stimulate ovulation and conceive a child.

Some studies show that treatment with clomiphene in women with ovulation problems can lead to the fact that in most of them (about 80%) the egg is released from the ovaries during the first cycle of taking the drug.

However, ovulation does not mean pregnancy. The chances of getting pregnant during the first cycle are only 30%. And yet, this is almost the same as the usual chances of conceiving a child (25%) in couples who do not have fertility problems. Almost half of the couples treated with klostilbegit, it is possible to conceive during the first six months.

Therefore, you should not be disappointed if you do not get pregnant in the first month of treatment. Treatment with clomiphene is usually limited to 6 consecutive months.

How to get pregnant quickly on clomiphene?

There is some connection between taking clomiphene and pregnancy, as this drug may be effective for some women who want to conceive a child. But the question arises, how quickly to take advantage of this?

  • Get the recipe – It is necessary to obtain a doctor’s prescription for the purchase of Clostylbegite or another analog. However, before the doctor writes a prescription, he will first evaluate how appropriate it is. Women who have been trying to get pregnant for less than a year may be advised to wait until treatment begins.
  • You can save money by buying more affordable analogues – Such medications are not covered by insurance, and it may take several procedures before the attempt to conceive a child is successful. Instead of buying the brand Clomid or Clostylbegit, you can save money and request a prescription for more affordable analogues.
  • Take the drug as prescribed – Tablets clostilbegyt or clomiphene is usually taken from the third to the seventh day of the menstrual cycle. However, some doctors may advise taking them on the fifth or ninth day of the cycle. It is important to remember that the 1st day of the cycle is the day when true menstrual bleeding (menstruation) begins, and not daub (light spotting).
  • No need for a daily ultrasound – Your doctor may suggest you to follow the effect of receiving clomiphene for ovulation, every day of the ultrasound examination. This procedure does not guarantee that pregnancy will occur. So, this is just an expensive way to monitor, and you can opt out of it to save money.
  • Sex every other day – Starting from the seventh day of the cycle, you can plan sexual acts every other day, so that spermatozoa have time to form in the partner’s body. Avoid having more frequent sex, as this can reduce your chances of getting pregnant.
  • Make sure to start ovulating with a test – To check whether ovulation has started, you can use a special test for this. You can buy it without a prescription. He is able to show that it is time for conception. If the ovulation test is positive, sexual intercourse should continue for two consecutive days. After that, you should return to the normal schedule.
  • Check if you are pregnant – On the 28th day or later, with the help of a home pregnancy test, you can check how successful the treatment is. You don’t have to wait too long to find out!

Negative consequences from trying to get pregnant with Clostilbegyt

Although there is a link between taking Clostylbegit and pregnancy, side effects may occur when using it, and they should be given special attention.

Minor side effects

Like all other medications, clostylbegit can cause some side effects. These include abdominal pain and swelling, weakness, nausea, vomiting, insomnia, blurred vision, fatigue, headache, depression, and weight gain. Some women may develop ovarian cysts.

The birth of twins

Women who are treated with fertility drugs have a 10% chance of having twins. This is due to the release of more than one egg per cycle as a result of drug stimulation of ovulation. In rare cases, triple or even larger multiple pregnancies also develop, which can increase the risk of complications such as miscarriage.

Clostilbegyt

Emotional aspects

Infertility treatment can be a source of emotional stress due to waiting and the lengthy treatment process. Therefore, a woman will need the support of a partner or friend to go through all the doctor’s examinations and follow-up steps related to treatment.

Ovarian hyperstimulation syndrome

The use of clomiphene citrate together with other powerful fertility drugs sometimes leads to the development of ovarian hyperstimulation syndrome (OHSS). This condition is characterized by bloating and increased body weight. Some women also experience shortness of breath, pelvic pain, dizziness, nausea, and vomiting. This condition occurs when the ovaries produce multiple eggs. At the same time, they become several times larger than their normal size, releasing fluid into the abdominal cavity. Usually, no treatment is required, although in some cases, hospitalization may be required for monitoring.

Ovarian cancer

While this is a concern, research shows that using fertility drugs does not necessarily increase the risk of ovarian cancer, even if the course takes more than 12 months.

Coronavirus and pregnancy: what is the danger of COVID-19 for expectant mothers

Scientists believe that the coronavirus attacks people with weakened immune systems. These include pregnant women. The body of the future mother works for two: for herself, and for the baby. In normal times, doctors recommend that women “in a position” to monitor their health as much as possible and not expose their body to additional stress. And during the coronavirus epidemic, expectant parents need to be especially careful. How does COVID-19 (danger of COVID-19!) affect pregnancy and what happens if the virus is detected in a pregnant woman? Is it possible not to observe the self-isolation regime and go to a medical institution? Should I be afraid for my health?

What is the danger of coronavirus during pregnancy

According to official data, infection of a pregnant woman with coronavirus can lead to premature birth and cesarean section. Moreover, the risk of death during childbirth or abortion increases.

Doctors strongly recommend that pregnant women self-isolate for the entire period of quarantine and contact their relatives and friends only with the help of modern means of communication.

How does coronavirus affect pregnancy and the baby

There is no exact data on the effect of COVID-19 on the unborn child. Scientists have not yet found out what malformations the virus provokes. However, the severe course of the disease in the mother can lead to the death of the fetus.

danger of COVID-19

WHO (World Health Organization) in its guidelines highlights the possible impact of drugs used in the treatment of coronavirus. Their toxic effects can lead to pathologies of fetal development.

The danger of Covid-19 during pregnancy in the 1st trimester

In the guidelines for the prevention, diagnosis and treatment of coronavirus, there is a separate item “Obstetric tactics for COVID-19”. It says that obstetric tactics are determined by the condition of the future mother and fetus, as well as the duration of pregnancy. In the 1st trimester (up to 12 weeks), if the patient carries the coronavirus very hard, it is possible to terminate the pregnancy after the end of treatment. This is due to the toxic effect of drugs on the child.

However, to terminate a pregnancy in the early stages of coronavirus can also be during the progression of the disease, if the life of the future mother is at risk (respiratory failure progresses, bleeding occurs, the fetus dies or other complications occur). In this case, the woman is carried out by caesarean section.

Whether pregnant women comply with the quarantine?

Yes, because pregnant women are at risk. The main reason is that the effect of the pathogen on the unborn child has not been studied. Therefore, all pregnant women are advised to observe the strictest quarantine and to have as little contact with other people as possible.

The danger of Covid-19 is no joke! Many couples are planning a pregnancy. To do this, many women buy clomid online. However, during the coronavirus period, doctors recommend that attempts to conceive a child be abandoned until the epidemiological situation stabilizes and that this issue be returned to after the quarantine measures are lifted.

Does ovulation happen before menstruation

Does ovulation happen before menstruation – this question torments a lot of women. Fertilization of the egg is possible only if ovulation occurs before the cycle. The best time for pregnancy is in the middle of the menstrual cycle. Ovulation before menstruation occurs, but very rarely, in such cases, two eggs mature, and a woman can give birth to twins. In this case, this may occur either due to the onset of repeated ovulation, or due to a failure of the cycle.

How long before the appearance of bloody discharge should ovulation occur

After a follicle has formed in the ovary, the inner lining of the uterus begins to increase. After that, the egg enters the fallopian tube, this moment comes about two weeks after menstruation, until the 16th day before it. These processes are extremely important for the intended fertilization of the egg.

After the egg enters the body of the uterus, spermatozoa also penetrate here, also through the fallopian tube, only on the other side. Only after the meeting of the egg with the sperm is fertilization performed. If this does not happen, the egg is excreted by the body outside, that is, menstruation occurs. It turns out that you can get pregnant a week before your period, although the chances are not so great. 5 days before their onset – even less.

Gynecologists believe that the optimal cycle of menstruation is 28 days, the time for conception is the middle of the cycle. At this point, everything is in place for a successful fusion of the egg with the sperm.

How long does the ovulation period last

Those women who plan to conceive, keep a calendar of ovulation dates. And this is correct: in order for conception to occur for sure, you need to know the period and duration. Based on the total duration of menstruation, the ovulatory period occurs:

  • with a cycle of 21 days for 5-9 days;
  • with 25 after 9-13 days;
  • with 30 for 16-20 days;
  • with 35 for 19-23 days.

Provided that the monthly regularity does not differ, then it is extremely difficult to correctly calculate the day of the onset of the ovulatory period. In this case, it is better to use other, more accurate methods of deduction. It lasts for each woman in different ways.

Answering the question whether there can be ovulation before the most monthly, we come to an unambiguous – in most cases it can not. It happened that women got pregnant before their periods – such cases are very rare.

Gynecology knows cases when women get pregnant on the day of the cycle, which is considered completely zero. This is explained by changes in the hormonal background, this happens against the background of emotional state, stress and other factors.

Due to severe stress, the menstrual cycle can shift, affecting the period of ovulation. As a result, two ovaries are able to secrete an egg. Not necessarily on the same day, it can happen on different days, and pregnancy will occur during menstruation.

Can it come sooner

In cases where a woman’s cycle is 35 days, even if she is absolutely healthy and her monthly periods come regularly, the release of a mature egg may occur earlier. And the fertile period-later for a week or a little longer.

This can provoke:

  • Hormonal disorders in the body.
  • Emotional overstrain and stress.
  • Weakened immune system.
  • Exacerbation of chronic diseases.
  • Violation of metabolic processes Overeating or, conversely, starvation.
  • Sudden climate change.
  • Heavy physical activity

The fertile period may also shift due to the withdrawal of contraceptive drugs, after an abortion or due to a miscarriage.

Does the absence of ovulation before pregnancy mean conception

You can conceive a child only when a woman has matured an egg. The absence of ovulation indicates that this process does not occur in the body of the expectant mother. This means that there can be no question of any pregnancy. In such cases, you need to go to the gynecologist and find out the cause of what is happening. The root cause of this may be a hormonal imbalance.

ovulation before menstruation

You can correct it with a specially selected therapy. If the cause cannot be established, doctors resort to radical methods, for example, during the period of alleged ovulation, the patient is injected with a drug that causes the formation and maturation of the follicle with the further release of the egg.

Is it possible to fertilize an egg after ovulation

No, a miracle, in this case, will not happen. A day after ovulation, women have a period that gynecologists call absolute infertility. For those who do not know the answer to the question of whether there can be ovulation before menstruation, we explain the essence of what is happening during the ovulatory period.

Ovulation divides the monthly cycle into two parts. The first is the phase of follicle maturation (duration, on average, 6-9 days). The second is the yellow body phase, the duration of this period lasts, depending on the cycle, and is, on average, 14 days. The second refers to the period of absolute infertility.

Pregnancy does not occur because a mature and ready-to-fertilize egg lives only 24 hours. Sometimes it can live even less. After it begins to collapse.

Can the ovulatory period occur before menstruation

The moment when the egg enters the uterus depends on the hormonal level and the duration of the follicular phase. In some young girls, these processes are very slow. Ovulation and pregnancy before menstruation are possible, due to the fact that the first phase becomes a little longer than usual. The primary cause of this may be a deficiency of the hormone estradiol. The moment of ovulation in such cases falls on the day of the beginning of menstruation, and the cycle itself should move.

Menstruation can not begin at the time of rupture of the follicle, because here comes the luteal phase, which lasts 14 days plus / minus 2 days.

If the ovulation period occurred at the beginning of the cycle and at this point the couple had unprotected contact, then the probability of fertilization remains high. In women in such cases, it is believed that ovulation occurred just before menstruation. In fact, the cycle, or rather its duration, has increased due to the follicular phase.

Probability of fertilization a week before the cycle

If pregnancy is not included in the family plans, then you need to be protected before the cycle constantly, even for a week. Although ovulation can not occur a week before menstruation, there is a chance of fertilization. This applies to young girls and women on the verge of menopause. In medical practice, such cases have happened. The reason for this may be too long periods, irregular cycles or severe stress loads.

The calendar schedule of pregnancy protection in such cases does not work, the probability of unwanted fertilization increases. In cases where the release of a mature egg fell on the period a week before the cycle, the woman must necessarily feel the characteristic symptoms of the fertile phase.

Is there a chance of pregnancy a day or two before the cycle

Many women believe that this is impossible. This statement is false, in fact, there is such a probability, although it is scanty. If a woman is absolutely healthy, then the greatest chances of pregnancy, namely 95%, fall in the middle of the cycle, the chance of fertilization of the egg a day before menstruation is reduced to 1 %, but it still exists. Gynecologists believe that unwanted pregnancies in women occur due to the fact that they simply incorrectly calculate the ovulatory period or because of a violation of the cycle itself.

Can ovulation be more than once

In almost all healthy women, ovulation occurs repeatedly during their lifetime. The regularity of the cycle does not play any role here. The approximate time of the second one is 24 hours or 2/3 days after the first one. The maximum difference is 1/1. 5 weeks in the same cycle. This fact is explained by the fact that both ovaries simultaneously matured eggs. At the time of release, the second hormone level decreases, but the probability of fertilization remains.

In conclusion: ovulation before menstruation

Summing up all the above, it can be noted that even the healthiest representative of the fair sex can have shifts in the ovulatory phase – this is the answer to the main question, which was mentioned above, whether there can be ovulation a week before menstruation, a day or just before them.

Such deviations are temporary, most often the regularity of the cycle is restored by itself. If this is a consequence of pathological changes in the body, then you can not do without the help of doctors.

Methods of ovulation stimulation at home

In gynecology, there are often situations when a woman can not conceive due to the lack of ovulatory periods, i.e. due to anovulation. In such clinical cases, it is necessary to stimulate the maturation and release of the egg. There are many methods to stimulate ovulation at home. But the specific choice is determined by the degree of anovulation. In some cases, you can cope with the problem yourself, using home techniques, and in others you can not do without medical intervention.

When stimulate ovulation at home is needed

If the patient suffers from anovulation, or the egg rarely matures and leaves the follicle, then the stimulation of this process is shown, thanks to which thousands of patients have already managed to experience the happiness of motherhood.

  • Usually, the indications for stimulation are such situations when more than a year of regular sexual relations in the absence of protection do not lead to conception.
  • If the couple is older than 35 years of age, the time during which it is not possible to get pregnant is reduced to six months.
  • Ovulation stimulation at home and even in the clinic is meaningless if there is male infertility.
  • If the patient suffers from tubal obstruction, then stimulation can provoke ectopic fixation of the embryo. Therefore, patients are recommended to undergo laparoscopy beforehand, only after the procedure, in the absence of obstruction, stimulation is allowed.

Methods of stimulating the output of the female cell

Many women repeatedly ask the question of how to stimulate ovulatory processes and how this can be done. First of all, it is necessary to undergo a thorough examination, so that when self-stimulation does not harm your own health. Home stimulation is quite a difficult task, but with a properly thought-out approach, it is quite feasible.

How to stimulate ovulation at home

For stimulation, you can use medications (for example, clomid) and vitamins, herbs and certain nutrition programs, healing mud or essential oil therapy, etc. More recently, the diagnosis of “female infertility” could destroy the happiness and life of many patients, but with the help of stimulating the maturation and release of the egg, such women have a real chance.

Such a measure is ideal in the case of ovarian polycystic disease, as well as for patients with a variety of menstrual disorders, anovulation and other abnormalities. But it should be carried out only after the normalization of thyroid hormones, androgens and prolactin, otherwise the stimulation will be ineffective. In general, there are many methods, so everyone can choose the most convenient option for themselves. Although any choice should be agreed with the doctor, since only he will be able to choose the most appropriate incentive option in each individual case.

Stimulate ovulation at home: Vitamins

One of the most effective methods to stimulate ovulation is vitamin therapy. For the successful maturation and release of the egg, a woman must have a sufficient supply of trace elements and vitamin substances in the body. To achieve this, you need to provide the diet with the necessary nutrition, competently making a daily menu. To begin with, it is worth enriching the body with folic acid, which is so important that when it is deficient, all sorts of intrauterine pathologies occur.

In addition, it is necessary to replenish the necessary content of potassium iodide, for which the diet includes iodized salt. If you decide to take complex vitamin preparations, it is better to choose from those that are recommended for nursing and pregnant women. The diet must include as many vegetables, berries, herbs and fruits as possible. These foods are an important stimulating factor for ovulation. It is also recommended to eat more fish, and it is better to refuse black coffee and tea or drink such drinks very rarely. It is necessary to give up unhealthy habits like alcohol or cigarettes, which have an extremely negative effect on the maturation and output of cells.

Main stages of stimulation

If the drug Klostylbegit is chosen as a stimulant, then its reception falls on the 5-9 day of the cycle, and Puregon or Menogon begin to drink from 2 to 10 days. The exact timing should be set by the doctor depending on the situation. When to start stimulation and how long to continue the procedures or courses depends on the health of the uterus and ovaries, which is determined by ultrasound examination. The doctor periodically prescribes a woman control ultrasound until the follicles grow to 21-25 mm in size. And to avoid the formation of follicular cystic formations or follicular regression, patients are prescribed HCG injections. Such a procedure promotes the launch of ovulatory processes.

If everything goes well, then after 1-1. 5 days after the chorionic injection, the follicle will burst and the female cell will begin to exit. If the ultrasound diagnosis shows ovulation, the patient is prescribed injections of Utrozhestan or Progesterone to further support the yellow ovarian body. When applying Clostilbegyt, as they say patients are often able to achieve conception.

Important! The doctor also takes into account the male factor, so he specifies the specific terms and frequency of sexual intimacy in the process of stimulation. With good spermogram indicators after hCG injection, sexual contacts should be carried out every day or every other day until the end of the ovulatory period.

If a positive result is not achieved after three times the use of Clostylbegit, it is recommended to undergo a more thorough diagnosis and use other therapeutic methods. Before performing stimulation, the patient must pass laboratory tests for syphilis, HIV and hepatitis, smear for microflora and oncocytology, ultrasound diagnostics of the mammary glands, check the patency of the fallopian tubes, etc. The therapist must conclude that the patient is capable of carrying a child.

Contraindications to ovulation stimulation at home

Not all patients can be ovulated. For example, if there are pathological processes in the female body that prevent conception and full-fledged gestation, then stimulation is not carried out. Such pathologies include adhesions in the tubes, tumors of reproductive structures, etc. In addition, do not perform stimulation, if before this 6 times such a procedure did not give any positive dynamics.

Relative contraindications for performing a stimulating procedure include an age exceeding the 35-year limit. This restriction is due to the fact that in such a clinical situation, the probability of giving birth to an unhealthy child with a disability or developmental abnormalities seriously increases.

Coronavirus in pregnant women

Coronavirus in pregnant women: Infection with COVID-19 during pregnancy can affect not only the health of the mother, but also the development of the child, according to obstetricians and gynecologists. So, the coronavirus can affect the slowing of fetal growth, provoke incorrect laying of its vital organs, and also lead to prematurity of the child.

Is coronavirus dangerous for pregnant women?

If a woman has contracted a coronavirus infection in the second trimester of pregnancy, this can lead to a slowdown in the development of the fetus.

At the same time, there is a possibility that the effect of CAVID-19 on the child will continue after the recovery of the expectant mother, the expert believes. “So, in the first trimester, a virus carried by a pregnant woman can affect the growth of the fetus, and in the second — cause a slowdown in the development of the child,” the doctor said.

Coronavirus in pregnant women

According to her, such consequences are associated with respiratory failure – in a woman in the late stages of pregnancy, the stomach presses on the lungs, thus reducing their volume.

In addition, the coronavirus also affects red blood cells (red blood cells that supply the body with oxygen).

“Red blood cells lose the ability to carry oxygen, respectively, the fetus begins to experience oxygen starvation, so automatically slows down and its growth and development»

Coronavirus in pregnant women: facts

Experts believe that only patients who have COVID-19 in moderate to severe forms, and it is during the second or third trimester, should be afraid.

According to the doctor, with this course of the disease, the fetus may be so short of oxygen that doctors — in order to alleviate the condition of the child — often resort to terminating the pregnancy by caesarean section.

In this case, the woman herself often suffers from the inability to breathe, so this operation is also carried out in order to save the life of the woman in labor, Marian Knight, a professor at Oxford University in the UK, previously told the BBC.

Ed Mullins, a British gynecologist at the Queen Charlotte and Chelsea Hospital, also stated that when the fetus develops distress syndrome, childbirth is accelerated artificially. “This is done in order to provide more effective treatment for low oxygen levels in a woman,” the medic explained.

Transmission of the virus

As for the transmission of coronavirus from mother to child in utero, such cases have not yet been recorded. “The fetus is not a direct target for COVID-19. The virus has no proven teratogenic effect (disruption of embryonic development due to external factors) on the fetus. The placental barrier is really good for him. As a rule, children are born healthy».

She added that in order to avoid serious disorders in the body of a pregnant woman and fetus, expectant mothers with coronavirus should be isolated in time and placed under medical supervision. “Remember that stress is the main danger of a successful pregnancy. Do not read unverified news, follow all hygiene measures and be positive, ” the medic said.

Can ovulation occur during pregnancy?

Ovulation is the threshold of conception and pregnancy. This is the period of maturation of the female sexual egg. There is no ovulation process — there is no pregnancy. Can ovulation occur during pregnancy? Does clomid help ovulation?

When an egg Matures in the follicle of the female ovary, it leaves it and goes through the fallopian tubes to the uterine cavity. This process is called ovulation and means the readiness of the woman’s body to conceive. Against this background, hormonal changes occur, which are accompanied by painful and aching sensations in the lower abdomen, thick vaginal discharge. It is during ovulation that a female egg can be fertilized by a male sperm during sexual intercourse. If this did not happen, conception did not take place, then it is removed from the body after a while. This is the period of menstruation — the beginning of the menstrual cycle.

Can ovulation occur during pregnancy?

When an egg is fertilized by a sperm during ovulation, it moves up the fallopian tube again and attaches to the wall of the uterus. Pregnancy occurs, the embryo develops. It is logical that the female body directs all its forces to the healthy bearing of the baby. At the same time, for 9 months, the eggs no longer Mature. It is so arranged by nature that after the onset of an “interesting” position, ovulation can harm the woman and the embryo.

Once fertilization has already occurred, the production of new eggs is no longer needed by the woman’s reproductive system. Her body is rebuilt: the ovaries do not produce eggs, the cervix is blocked by a specific mucous membrane, and sperm can no longer show activity in it.

Ovulation occur during pregnancy – Exception to the rule

If we still assume that ovulation during pregnancy is possible and a new conception can occur, then the fetal egg simply cannot attach to the uterus, because the embryo is already developing there.

There are no rules without exceptions. Therefore, sometimes the process of ovulation occurs when carrying a baby. But only in the first month of pregnancy. At its early stage, there is a possibility of a second egg coming out of the ovary and fertilizing it. To date, several cases of re-fertilization after pregnancy are known. But these are the rarest exceptions to the rule. That is, a woman can not bear two embryos at the same time with different terms of conception. A multiple pregnancy is the carrying of two or three babies conceived at the same time. They are born in the process of one birth, one after another.

About ovulation tests

Today, they help couples who want to have a child and try to determine whether the female body is maturing eggs, use the optimal day for conception.

All ovulation tests are based on the same principle. Their effect is to change the color of the indicator strip as a result of getting luteinizing hormone. Its level during ovulation is the highest, which is what the test responds to. So can it happen that a pregnant woman’s ovulation test will show a positive result? Practice shows that this is excluded. Such a test cannot be positive for the expectant mother. However, the same practice confirms that due to their inattention, many representatives of the weaker sex use a different test — for pregnancy. That’s why the result is positive. And this is quite natural. After all, the task of such a diagnostic method is to confirm the “interesting” position. It is confirmed by the presence in the blood of the pregnancy hormone-chorionic gonadotropin. The indicator strip of the pregnancy test responds to its presence.

The ovulation test can be false positive, that is, unreliable, in some cases. We are talking about kidney failure, hormonal dysfunction of the body, postmenopause. Then it is possible to increase the level of luteinizing hormone in the blood.

So, the onset of ovulation in pregnant women is impossible, so it is already laid down by nature. Therefore, during this period, during intimate relationships, contraceptives are no longer used— there is no need for them.

Clomiphene and ovulation

Clomiphene (clomiphene citrate), commonly known under the brand names Clostilbegit and Clomid – is a drug that is prescribed for ovulation and fertility disorders. This pharmacological agent can be used by women who do not ovulate, as well as those who have a lack of luteal phase. LH (luteinizing) and FSH (follicle-stimulating) are hormones that control the ovulation process. Various clinical and scientific studies have provided statistics that consumption of clomiphene stimulates the pituitary gland to produce more of these all-important hormones to normalize ovulation.

In modern times, clomiphene, discovered back in 1956, and ovulation continue to be closely related, as the drug has proven effective for ovarian stimulation and is therefore widely used for this purpose. Other drugs that also stimulate the process of egg release from the follicle are bromocriptine and metformin.

How does clomiphene work?

the body’s cells exchange information through substances such as hormones and neurotransmitters (neurotransmitters). they come into contact with the receptors of various tissues to cause a chemical reaction.

Clomiphene and ovulation

The mode of action and mechanism of the drug are quite similar to the female sex hormone-estrogen. Similarly, clomiphene comes into contact with a receptor present in the hypothalamus (an endocrine gland located in the brain). the drug blocks estrogen from showing its biological properties, while the body believes that this hormone is not enough. this automatically causes the body to produce more gnrh (gonadoliberin), which in turn causes the release of lh and fsh. In fact, FSH helps in the maturation process of follicles (or potential eggs) and therefore produces more estrogen. If clostilbegyt operates so that ovulation occurs more frequently.

How effective is it?

According to statistics, 70% of women report positive results within 6 months after the start of using the product, as evidenced by the solution of issues with ovulation. In addition, about 40% of women are reported to be able to conceive a child after starting treatment. There are several other factors that can affect the chances of getting pregnant, such as a woman’s age and weight. In addition, the period of the menstrual cycle, the frequency of sexual intercourse and male factors such as mobility, speed, shape and number of sperm can also influence the ability to get pregnant. The doctor may increase the dose over time to increase the chances of conceiving a child, as a low dose may not be sufficient for some patients.

Clomiphene and ovulation: what are the side effects?

In addition to the positive effect of clomiphene, as with many other drugs, there may be some side effects:

  • Breast sensitivity;
  • Significant weight gain;
  • Blurred and blurred vision;
  • Changes in normal sleep quality and rhythm;
  • Abdominal pain;
  • Mood swings;
  • Severe bleeding during menstruation;
  • Spotting;
  • Sensations of a rush of heat;
  • Nausea;

Another side effect of clomiphene is dryness of the cervical mucosa, which can affect the quality of sexual intercourse; however, this defect can be compensated by the use of vaginal lubrication.

As a side effect, OHSS (ovarian hyperstimulation syndrome) may occur. This condition is characterized by a reversible increase (edema) of the ovaries due to an active reaction of the body to hormones and is quite common (> 10% of women). OHSS should be suspected if excessive flatulence or bloating occurs. This can be a serious problem, but usually ovarian hyperstimulation syndrome that occurs due to the use of clostylbegit is a mild condition that goes away on its own. The severity of OHSS may increase if you take HCG (another fertility medication).

Clomiphene can lead to multiple ovulation, hence increasing the likelihood of twins (10% of births instead of – 1% without it) and triplets.

Some studies have shown that clomiphene, when used for more than a year, can increase the risk of ovarian cancer. Subsequent studies have not confirmed these findings, so we can not speak confidently about this.

According to statistics, the incidence of fetal diseases with the use of clomiphene does not exceed the level that is observed in conception without it. There are no data indicating a higher number of congenital abnormalities or spontaneous abortions after using this drug. although there are also studies that show that the number of congenital heart abnormalities is significantly higher with its use than with its counterpart for ovarian stimulation – letrozole.

Sexual acts when taking clomiphene

The period and frequency of sexual acts when using the drug is not much different from trying to get pregnant without any medication. The ideal time is considered to be two days before and after ovulation, so that the chances of pregnancy increase. The cycles of egg release from the ovary can vary, as in some women they are longer, while in others they are shorter. The ovulation period may even differ from cycle to cycle in the same woman. You can be disappointed if you get too hung up on conception, so it’s better to just relax and try to implement interesting ideas in the bedroom.

Estrogens: what are “female” hormones for?

Hormones are biologically active substances of organic nature that are produced by the endocrine glands. Entering the blood, hormones have a regulating effect on the entire body, in particular, on metabolism and physiological functions. One of the most important hormones is estrogen. What does estrogen affect and what can its lack and overabundance lead to?

Estrogen – what is this hormone?

The term “estrogen” refers to a whole subclass of steroid female sex hormones, which are produced mainly by the ovarian follicular apparatus. There are three types of estrogens: estradiol, estriol, and estrone. By the way, such hormones are also found in the male body, where the testicles, adrenal cortex and extra-gonadal tissues are responsible for their production. But as in men the hormone estrogen is produced in minimal numbers, they are considered to be female.

What is the hormone oestrogen responsible for in women:

  • Development and functioning of the reproductive system. Estrogen stimulates the development of the uterus and fallopian tubes, as well as the vagina, stroma, and ductal mammary glands. Thanks to the female hormones estrogen, girls in adolescence have secondary sexual characteristics and menstruation begins — it is estrogen that contributes to the regular rejection of the endometrium from the uterus.
  • The circulatory system. The hormone estrogen increases the concentration of iron, copper and thyroxine in the blood. In addition, it has an anti-sclerotic effect, increases the amount of high-density lipoproteins in the plasma, which reduce the risk of atherosclerosis and various diseases of the cardiovascular system. Also, the “female” hormone reduces the content of low-density lipoproteins, which are one of the main carriers of cholesterol.
  • Growth and restoration of bone tissue. Estrogen in the body prevents the leaching of calcium, protects joint tissue and stimulates the recovery of bone cells.
  • Elasticity of the skin. “Female” hormone helps to activate the production of collagen, which determines the elasticity of the skin.
  • Memory and psychoemotional state. Estrogen receptors are concentrated in areas of the brain that are responsible for information assimilation, as well as mood and emotions.

In short, estrogen is a key factor in maintaining women’s health and beauty. By the way, it also affects women’s libido, which is also very important for a happy life. This hormone is directly related to the General well-being of the fair sex. A woman with normal levels of the hormone estrogen is less irritable, she does not have edema, unreasonable headaches and problems with excess weight.

What can lead to a lack or overabundance of estrogen

As it is already clear, the level of estrogen in the blood directly affects the physical and psychological state of a woman, so it is very important to monitor this indicator and take measures for any imbalance.

The consequences of the fall in estrogen levels:

  • various pains, mainly headache and heart, as well as pain in the lower back, back;
  • deterioration of thermoregulation, in particular, hot flashes;
  • bone fragility;
  • vasoconstriction;
  • memory impairment;
  • appearance of wrinkles;
  • fluctuations in the emotional background.

With an excess of estrogens in women, there are:

There are several reasons for reducing and increasing estrogen in a woman’s body. This may be a disorder of the functioning of the pituitary gland, an unbalanced diet, too high physical activity, menopause and the period preceding it.

Excess estrogen is rare, usually it is necessary to correct the lack of this hormone. The most common cause is age-related changes in the female body that begin after the age of 40. Unfortunately, it is impossible to avoid them and ensure eternal youth, but there are ways to slow down such processes.

estrogen

What can I do if the hormone is not enough?

The lack of natural hormones can be partially compensated by taking phytoestrogens. These are natural substances of plant origin. The most studied of these is genistein. It shows similar activity to natural hormones, helps to strengthen bones by maintaining the processes of formation and mineralization of bone tissue, plays an important role in maintaining joint health by regulating metabolic processes in the cells of articular cartilage. By the way, bone mineralization also reduces the risk of a dangerous disease-osteoporosis.

Clomid and bodybuilding

Clomid and bodybuilding – Antiestrogens play a very important role in strength sports. These are substances that an athlete should always have, especially when taking exogenous hormones. Their main purpose is to restore the hormonal background after a course of AAS. The problem is that after a course of taking steroids, the level of your own testosterone is very low, and the level of female hormones is quite high. Antiestrogens perform two very important functions: they reduce the nature of the action of estrogens in the athlete’s body, block the receptors and stimulate the production of LH and FSH, which quickly leads to optimization of the level of their own testosterone in athletes.

Clomid: Pharmacological action

Clomid is a drug with an anti-estrogenic effect.

Their mechanism of action is based on blocking the perception of estrogen by the ovarian and hypothalamus receptors. There is an increase in the secretion of lutein and follicle-stimulating hormone.

Due to this, the maturation process and the hormonal function of the follicle begins to activate.

The result of using the drug is the stimulation of ovulation and an increase in the amount of estradiol in the General bloodstream.

About Clomid

Clomid (synonyms – clomiphene citrate, clomiphene, clostylbegit) is a synthetic drug of non-steroidal structure from the group of anti-estrogenic triphenylethylenes. It is classified as a selective modulator of estrogen receptors with dual properties: agonistic and antagonistic. This is due to the fact that in some cases clomid blocks the action of estrogen, affecting directly the receptors, and in others it activates the receptors, i.e. it acts in the body’s tissues as a real estrogen. If the body contains a low concentration of estrogens, then clomid shows a moderate estrogenic effect, but if it is increased, it has an anti-estrogenic effect. In this case, the drug does not have androgenic or gestagenic activity.

Clomid and bodybuilding

Initially, the drug was intended for women to stimulate ovulation in infertility due to hypothalamic-pituitary ovarian disorders. The effect of the drug is designed to block estrogen receptors in the ovaries and hypothalamus, increase the secretion of gonadotropins in the pituitary gland and increase the concentration of estradiol in the blood.

Clomid and bodybuilding

The drug is extremely popular in the field of bodybuilding, powerlifting and weightlifting. In male athletes, clomid acts as an antiestrogen due to its ability to block the effects of estrogens on the hypothalamus, which triggers a chain reaction:

  • stimulates the production of gonadoliberin (GnRH);
  • increases the production of luteinizing hormone by the pituitary gland;
  • raises the level of hormones that stimulate the testicles;
  • increases the production of testosterone by the testes.

Since clomid acts directly on the pituitary gland, it provokes an increase in the production of natural (natural) testosterone. This is why clomid is essential for bodybuilders taking anabolic steroids. The drug is especially necessary at the end of the course, because after stopping taking steroids, athletes have a decrease in the production of natural testosterone and a decrease in its concentration in the body.

If you do not restore the normal level of testosterone, it is fraught with negative consequences, in particular, significant losses of muscle volume and strength characteristics. The absence or insufficient level of androgens (in particular testosterone) gives dominant advantages to the catabolic hormone cortisol. It directly affects the protein synthesis in muscle cells and triggers a catabolic metabolism. Among bodybuilders, this process is called post-steroid breakdown, because it can destroy almost all the created muscles. Taking clomid can prevent this process.

In addition, usually at the end of the cycle, almost all athletes also face the problem of an overabundance of estrogen. The combination of “an increased concentration of estrogen plus a reduced amount of testosterone” significantly increases the risk of developing gynecomastia in bodybuilders. Taking clomid allows you to simultaneously solve both of these problems.

Basically, clomid is very effective in bodybuilding, because its property to lower the activity of estrogens in the body warns:

  • development of gynecomastia;
  • the deposition of fat and formation of fatty folds;
  • accumulation of fluid in the body.

Clomid is similar in its characteristics to nolvadex (tamoxifen), in principle, both of these drugs are interchangeable. What to take is preferable, only the athlete can decide based on a comparative analysis: contraindications, side effects and pricing policy.

Very often, clomid is used together with Proviron, since this combination is considered the most effective for reducing the manifestation of aromatase and increasing the ratio of androgens to estrogens.

Clomid and bodybuilding dosage and administration features

To consolidate the results and stimulate the production of natural testosterone, it is necessary to take clomid at a dose of 50-100 mg daily. This amount is enough to return the normal level of testosterone in the body within two to three weeks of taking it. It is undesirable to use clomid for more than 4-6 weeks in a row.

Since clomid can not sharply raise the level of testosterone (the drug is characterized by a gradual rise), it is recommended to introduce it directly at the end of the course and during the recovery period, and for a sharp increase in the androgen hormone and its increased production by the body, take it in combination with anabolic steroids HCG (human gonadotropin).

HCG should not be taken for more than three weeks, as excessively high levels of testosterone and estrogen can cause the opposite effect. Clomid should continue to be taken after the end of the HCG course.

Some experts recommend using a slightly different dosage and regimen for the “correct” exit from a long course of strong steroids. In the first days of the recovery period, clomid is taken at an increased dose 150-300 mg daily, then for about two weeks — 100 mg, and then until the end of the course — 50 mg daily.

Clomid for men

For men, the drug is prescribed for lack of testosterone as hormone replacement therapy. This condition can overtake any man at any age.

At the same time, the drug Clomid eliminates other problems that have occurred against the background of hypogonadism:

  • Energy depletion;
  • State of depression;
  • Loss of vitality;
  • Muscle atrophy;
  • Pain in the muscles;
  • Lower libido;
  • Erectile dysfunction;
  • Body weight gain;
  • Osteopenia;
  • Osteoporosis;
  • Anemia of a moderate nature;
  • The possibility of developing Alzheimer’s syndrome/neoplasms in the prostate.

The drug Clomid is used in combination with other medications for gynecomastia.

Pregnancy after 45 years and chances of giving birth

Many doctors believe that pregnant after 45 years is not the best time to conceive a child, even dangerous. Others support women who become pregnant after 43, and believe that this is the most appropriate time to conceive a child. With late pregnancy, a reliable Foundation is laid that allows you to give birth to a healthy child.

Before you figure out whether you can still get pregnant in 40 years from the first time, a woman should understand what the psychological, biological and calendar age is. Each organism is different, so later fertilization is only on the calendar, and for health reasons just right. If a woman at 44 feels the strength and desire to become a mother, you need to use the moment.

Features of ovulation after 40 years

Age is one of the main factors affecting a woman’s ability to conceive. The supply of oocytes in the body is limited. It lays at the stage of embryonic development. Some of the eggs die in adolescence. The remaining oocytes are consumed with each menstrual cycle. Therefore, by the age of 40, there are very few eggs left. The work of the reproductive organs during this period changes dramatically. This affects the overall well-being of a woman.

pregnant after 45 years

Ovulation after 40 years is much less common than at a younger age. This is due to a physiological decrease in the level of estrogens in the body. The hormone is responsible for the maturation of eggs and increasing the thickness of the endometrium. In addition, it is responsible for preserving youth. When the production of estrogens is disrupted, there is a change in the duration of the menstrual cycle. In some women, it completely disappears. Lack of estrogen in the body is accompanied by the following signs:

  • Deterioration of skin elasticity;
  • Frequent mood swings;
  • Depression libido;
  • Changes in the nature of selections.

Life expectancy of an egg after ovulation in a woman’s body after 40 years

Doctors say that ovulation after 40 years rarely leads to a successful pregnancy.

This is due to a reduction in the life span of the egg after it leaves the follicular walls. Until the age of 40, it lives an average of 24-48 hours. This figure decreases markedly with age. Pregnancy in this case becomes possible if the man’s spermatozoa are active enough. In other cases, you may need the help of specialists.

Pregnant after 45 years: Symptoms of ovulation

In General, ovulation after 40 years has no special distinctive features. It runs the same way as before. Some women do not notice any characteristic symptoms of the fertile period. It may be accompanied by the following symptoms:

  • Increased sexual desire;
  • Heaviness in one of the ovaries;
  • Flatulence;
  • Increasing the volume of vaginal secretions and changing their consistency;
  • The increased sensitivity of the mammary glands;
  • Increased sense of smell and taste.

When fertility increases, the position of the uterus changes. It rises high in the vagina and becomes softer. The throat opens slightly. This is necessary for unhindered penetration of seminal fluid into the genital tract. At the same time, the basal temperature index decreases.

An ovulation test helps you get more information. It responds to an increase in the hormone LH in the body. But the result should be interpreted in conjunction with other signs of ovulation. LH can increase not only during the fertile period, but also in the presence of gynecological diseases.

After the expected ovulation, the woman should visit the ultrasound again. The fact that the follicle has successfully ruptured is indicated by its disappearance and the presence of fluid behind the uterine cavity. In place of the follicle, a yellow body appears, which is characterized by uneven outlines. The absence of characteristic signs of the ovulatory period indicates luteinization of the follicle. This problem requires adjustment of the hormonal background with medication.

Choosing the right sex position

  • Missionary. The classic position, the man during sexual intercourse is on top, the woman lies on her back. The ejaculate is actually immediately delivered to the uterine cavity and fertilization will occur faster. The pose is considered universal, suitable for couples of any complexion.
  • Knee-elbow. The woman must kneel with her elbows on the bed, while the husband is behind her. Provides such deep penetration that the sperm immediately passes into the cervix.
  • The General’s posture. The partner lies down on her back, puts her feet on her husband’s shoulders, like shoulder straps.Posture to achieve the optimal penetration depth and thrills.

Clomid and pregnant after 45 years

Also, do not forget that after consulting with your doctor and his approval for the use of clomid, you can increase your chances of getting pregnant.